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Quantum Approximate Optimization algorithm (QAOA) aims to search for approximate solutions to discrete optimization problems with near-term quantum computers. As there are no algorithmic guarantee possible for QAOA to outperform classical…

Quantum Physics · Physics 2022-07-25 Bingzhi Zhang , Akira Sone , Quntao Zhuang

Quantum computing promises solutions to classically difficult and new-found problems through controlling the subtleties of quantum computing. The Quantum Approximate Optimisation Algorithm (QAOA) is a recently proposed quantum algorithm…

Quantum Physics · Physics 2024-12-24 Nicholas J. Pritchard

Combinatorial optimization is among the main applications envisioned for near-term and fault-tolerant quantum computers. In this work, we consider a well-studied quantum algorithm for combinatorial optimization: the Quantum Approximate…

Quantum Physics · Physics 2020-11-12 Sami Boulebnane

The aircraft loading optimization problem is a computationally hard problem with the best known classical algorithm scaling exponentially with the number of objects. We propose a quantum approach based on a multi-angle variant of the QAOA…

Running quantum circuits on quantum computers does not always generate "clean" results, unlike on a simulator, as noise plays a significant role in any quantum device. To explore this, we experimented with the Quantum Approximate…

Quantum Physics · Physics 2025-10-09 Abyan Khabir Irfan , Chansu Yu

Quantum computing is an emerging field on the multidisciplinary interface between physics, engineering, and computer science with the potential to make a large impact on computational intelligence (CI). The aim of this paper is to introduce…

Molecular docking is a critical process for drug discovery and challenging due to the complexity and size of biomolecular systems, where the optimal binding configuration of a drug to a target protein is determined. Hybrid classical-quantum…

Emerging Technologies · Computer Science 2025-03-07 Christos Papalitsas , Yanfei Guan , Shreyas Waghe , Athanasios Liakos , Ioannis Balatsos , Vassilios Pantazopoulos

Hybrid quantum-classical algorithms such as the quantum approximate optimization algorithm (QAOA) are considered one of the most promising approaches for leveraging near-term quantum computers for practical applications. Such algorithms are…

Quantum Physics · Physics 2022-06-16 Ruslan Shaydulin , Ilya Safro , Jeffrey Larson

This research explores the integration of the Quantum Approximate Optimization Algorithm (QAOA) into Hybrid Quantum-HPC systems for solving the Max-Cut problem, comparing its performance with classical algorithms like brute-force search and…

Quantum Physics · Physics 2024-10-22 Ishan Patwardhan , Akhil Akkapelli

Accurate determination of particle track reconstruction parameters will be a major challenge for the High Luminosity Large Hadron Collider (HL-LHC) experiments. The expected increase in the number of simultaneous collisions at the HL-LHC…

The prospect of quantum solutions for complicated optimization problems is contingent on mapping the original problem onto a tractable quantum energy landscape, e.g. an Ising-type Hamiltonian. Subsequently, techniques like adiabatic…

Quantum Physics · Physics 2025-10-17 Sebastian Egginger , Kristina Kirova , Sonja Bruckner , Stefan Hillmich , Richard Kueng

The quantum approximate optimization algorithm (QAOA) is one of the canonical algorithms designed to find approximate solutions to combinatorial optimization problems in current noisy intermediate-scale quantum (NISQ) devices. It is an…

Quantum Physics · Physics 2023-12-12 Ping Zou

This paper describes an application of the Quantum Approximate Optimisation Algorithm (QAOA) to efficiently find approximate solutions for computational problems contained in the polynomially bounded NP optimisation complexity class (NPO…

Quantum Physics · Physics 2021-07-28 Samuel Marsh , Jingbo Wang

Constrained combinatorial optimization with strict linear constraints underpins applications in drug discovery, power grids, logistics, and finance, yet remains computationally demanding for classical algorithms, especially at large scales.…

Quantum Physics · Physics 2026-04-07 Yajie Hao , Qiming Ding , Xiao Yuan , Xiaoting Wang

Quantum Approximate Optimization Algorithm (QAOA) is one of the most promising quantum algorithms for the Noisy Intermediate-Scale Quantum (NISQ) era. Quantifying the performance of QAOA in the near-term regime is of utmost importance. We…

Quantum Physics · Physics 2022-06-16 Ruslan Shaydulin , Yuri Alexeev

The Quantum Approximate Optimization Algorithm (QAOA) uses a quantum computer to implement a variational method with $2p$ layers of alternating unitary operators, optimized by a classical computer to minimize a cost function. While rigorous…

Quantum Physics · Physics 2024-11-19 Raimel A. Medina , Maksym Serbyn

At the High Luminosity Large Hadron Collider (HL-LHC), traditional track reconstruction techniques that are critical for analysis are expected to face challenges due to scaling with track density. Quantum annealing has shown promise in its…

Optimizing Reconfigurable Intelligent Surfaces (RIS) is a high-dimensional combinatorial challenge. Current quantum algorithms often simplify this problem by ignoring physical constraints like mutual coupling, which significantly degrades…

Computational Engineering, Finance, and Science · Computer Science 2026-05-08 Marco Pasquale , Erik M. Åsgrim , Stefano Markidis , Oscar Quevedo-Teruel

Protein folding -- the problem of predicting the spatial structure of a protein given its sequence of amino-acids -- has attracted considerable research effort in biochemistry in recent decades. In this work, we explore the potential of…

Quantum Physics · Physics 2022-04-06 Sami Boulebnane , Xavier Lucas , Agnes Meyder , Stanislaw Adaszewski , Ashley Montanaro

Until high-fidelity quantum computers with a large number of qubits become widely available, classical simulation remains a vital tool for algorithm design, tuning, and validation. We present a simulator for the Quantum Approximate…

Quantum Physics · Physics 2023-11-14 Danylo Lykov , Ruslan Shaydulin , Yue Sun , Yuri Alexeev , Marco Pistoia