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We study the data-driven selection of causal graphical models using constraint-based algorithms, which determine the existence or non-existence of edges (causal connections) in a graph based on testing a series of conditional independence…

Methodology · Statistics 2026-04-29 Daniel Malinsky

The problem of statistical inference in its various forms has been the subject of decades-long extensive research. Most of the effort has been focused on characterizing the behavior as a function of the number of available samples, with far…

Machine Learning · Computer Science 2024-11-12 Tomer Berg , Or Ordentlich , Ofer Shayevitz

Independence testing is a classical statistical problem that has been extensively studied in the batch setting when one fixes the sample size before collecting data. However, practitioners often prefer procedures that adapt to the…

Machine Learning · Statistics 2025-05-21 Aleksandr Podkopaev , Patrick Blöbaum , Shiva Prasad Kasiviswanathan , Aaditya Ramdas

Variable selection plays a crucial role in enhancing modeling effectiveness across diverse fields, addressing the challenges posed by high-dimensional datasets of correlated variables. This work introduces a novel approach namely Knockoff…

Machine Learning · Statistics 2025-01-31 Xiaochen Zhang , Yunfeng Cai , Haoyi Xiong

Thanks to its fine balance between model flexibility and interpretability, the nonparametric additive model has been widely used, and variable selection for this type of model has been frequently studied. However, none of the existing…

Methodology · Statistics 2022-01-10 Xiaowu Dai , Xiang Lyu , Lexin Li

Motivated by the gene co-expression pattern analysis, we propose a novel sample quantile-based contingency (squac) statistic to infer quantile associations conditioning on covariates. It features enhanced flexibility in handling variables…

Methodology · Statistics 2018-08-27 Jichun Xie , Ruosha Li

Two-stage randomized experiments are becoming an increasingly popular experimental design for causal inference when the outcome of one unit may be affected by the treatment assignments of other units in the same cluster. In this paper, we…

Methodology · Statistics 2022-10-21 Zhichao Jiang , Kosuke Imai , Anup Malani

We introduce a method to rigorously draw causal inferences---inferences immune to all possible confounding---from genetic data that include parents and offspring. Causal conclusions are possible with these data because the natural…

Methodology · Statistics 2024-03-12 Stephen Bates , Matteo Sesia , Chiara Sabatti , Emmanuel Candes

This paper is concerned with test of the conditional independence. We first establish an equivalence between the conditional independence and the mutual independence. Based on the equivalence, we propose an index to measure the conditional…

Methodology · Statistics 2021-05-18 Zhanrui Cai , Runze Li , Yaowu Zhang

Consider the multiple testing problem of testing null hypotheses $H_1,...,H_s$. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($\mathit{FWER}$),…

Statistics Theory · Mathematics 2007-06-13 Joseph P. Romano , Azeem M. Shaikh

We propose consistent nonparametric tests of conditional independence for time series data. Our methods are motivated from the difference between joint conditional cumulative distribution function (CDF) and the product of conditional CDFs.…

Econometrics · Economics 2021-10-12 Xiaojun Song , Haoyu Wei

Accurate simulation of complex physical systems enables the development, testing, and certification of control strategies before they are deployed into the real systems. As simulators become more advanced, the analytical tractability of the…

Robotics · Computer Science 2020-05-27 Lucas Barcelos , Rafael Oliveira , Rafael Possas , Lionel Ott , Fabio Ramos

The traditional framework for feature selection treats all features as costing the same amount. However, in reality, a scientist often has considerable discretion regarding which variables to measure, and the decision involves a tradeoff…

Methodology · Statistics 2023-02-14 Guo Yu , Daniela Witten , Jacob Bien

Replicability analysis aims to identify the findings that replicated across independent studies that examine the same features. We provide powerful novel replicability analysis procedures for two studies for FWER and for FDR control on the…

Methodology · Statistics 2019-03-01 Marina Bogomolov , Ruth Heller

We describe a data-efficient, kernel-based approach to statistical testing of conditional independence. A major challenge of conditional independence testing is to obtain the correct test level (the specified upper bound on the rate of…

Machine Learning · Computer Science 2025-09-23 Roman Pogodin , Antonin Schrab , Yazhe Li , Danica J. Sutherland , Arthur Gretton

In this article, we propose a novel strategy for conducting variable selection without prior model topology knowledge using the knockoff method with boosted tree models. Our method is inspired by the original knockoff method, where the…

Methodology · Statistics 2020-02-24 Tao Jiang , Yuanyuan Li , Alison A. Motsinger-Reif

The PC algorithm is the state-of-the-art algorithm for causal structure discovery on observational data. It can be computationally expensive in the worst case due to the conditional independence tests are performed in an…

Machine Learning · Computer Science 2021-09-13 Kai Zhang , Chao Tian , Kun Zhang , Todd Johnson , Xiaoqian Jiang

In clinical trials, hypotheses are frequently organized into hierarchically ordered families, requiring specialized testing strategies that account for these structured relationships. Existing gatekeeping methods-including serial, parallel,…

Methodology · Statistics 2026-04-14 Zhiying Qiu , Li Yu , Wenge Guo

Knockoffs provide a general framework for controlling the false discovery rate when performing variable selection. Much of the Knockoffs literature focuses on theoretical challenges and we recognize a need for bringing some of the current…

This paper studies the means-testing problem under weakly correlated Normal setups. Although quite common in genomic applications, test procedures having exact FWER control under such dependence structures are nonexistent. We explore the…

Statistics Theory · Mathematics 2026-02-26 Swarnadeep Datta , Monitirtha Dey