Related papers: Correcting for T1 bias in Magnetization Transfer S…
While typical qualitative T1-weighted magnetic resonance images reflect scanner and protocol differences, quantitative T1 mapping aims to measure T1 independent of these effects. Changes in T1 in the brain reflect structural changes in…
Purpose: To implement and evaluate a sequential approach to obtain semi-quantitative T1-weighted MPRAGE images, unbiased by B1 inhomogeneities at 7T. Methods: In the reference gradient echo used for normalization of the MPRAGE image, flip…
Background: Magnetization transfer (MT) saturation reflects the additional saturation of the MRI signal imposed by an MT pulse and is largely driven by the saturation of the bound pool. This reduction of the bound polarization by the MT…
Purpose: To address the systematic bias in whole-brain dual flip angle (DFA) T1-mapping at 7T by optimizing the flip angle pair and carefully selecting RF pulse shape and duration. Theory and Methods: Spoiled gradient echoes can be used to…
Purpose: To develop and validate a multi-parametric SAturation-recovery single-SHot Acquisition (mSASHA) cardiac T1 and T2 mapping technique with high accuracy and precision in a single breath-hold. Methods: The mSASHA acquisition consists…
Cardiac T1 mapping provides critical quantitative insights into myocardial tissue composition, enabling the assessment of pathologies such as fibrosis, inflammation, and edema. However, the inherently dynamic nature of the heart imposes…
Purpose: To implement and evaluate a new dictionary-based technique for native myocardial T1 and T2 mapping using Cartesian sampling. Methods: The proposed technique (Multimapping) consisted of single-shot Cartesian image acquisitions in 10…
Purpose: To develop a free-breathing myocardial T1 mapping technique using inversion-recovery (IR) radial fast low-angle shot (FLASH) and calibrationless motion-resolved model-based reconstruction. Methods: Free-running (free-breathing,…
Purpose: To develop a cardiac T1 mapping method for free-breathing 3D T1 mapping of the whole heart at 3T with transmit B1 (B1+) correction Methods: A free-breathing, ECG-gated inversion recovery sequence with spoiled gradient-echo readout…
Magnetic resonance fingerprinting (MRF) provides a unique concept for simultaneous and fast acquisition of multiple quantitative MR parameters. Despite acquisition efficiency, adoption of MRF into the clinics is hindered by its dictionary…
Purpose: Imaging biomarkers with increased myelin specificity are needed to better understand the complex progression of neurological disorders. Inhomogeneous magnetization transfer (ihMT) imaging is an emergent technique that has a high…
Purpose: Magnetization transfer (MT) and inhomogeneous MT (ihMT) contrasts are used in MRI to provide information about macromolecular tissue content. In particular, MT is sensitive to macromolecules and ihMT appears to be specific to…
Purpose: To develop a method for rapid sub-millimeter T1, T2, T2* and QSM mapping in a single scan using multi-contrast Learned Acquisition and Reconstruction Optimization (mcLARO). Methods: A pulse sequence was developed by interleaving…
Purpose: To develop a single-shot multi-slice T1 mapping method by combing simultaneous multi-slice (SMS) excitations, single-shot inversion-recovery (IR) radial fast low-angle shot (FLASH) and a nonlinear model-based reconstruction method.…
Superparamagnetic iron oxide nanoparticles (SPIONs) such as ferumoxytol are promising theranostic agents detectable with MRI. Relaxation time mapping offers reproducible, quantitative biomarkers of SPION distribution, but conventional…
Objective: To develop an accurate myocardial T1 mapping technique at 5T using Look-Locker-based multiple inversion-recovery with the real-time spoiled gradient echo (GRE) acquisition. Approach: The proposed T1 mapping technique (mIR-rt)…
Purpose: To develop an accelerated Cartesian MRF implementation using a multi-shot EPI sequence for rapid simultaneous quantification of T1 and T2 parameters. Methods: The proposed Cartesian MRF method involved the acquisition of highly…
Purpose: To study the effects of magnetization transfer (MT, in which a semisolid spin pool interacts with the free pool), in the context of magnetic resonance fingerprinting (MRF). Methods: Simulations and phantom experiments were…
Purpose: Magnetization transfer (MT) has been identified as the principal source of $T_1$ variability in the MRI literature. This study assesses the sensitivity of established $T_1$ mapping techniques to variations in the underlying MT…
T1 mapping is a quantitative magnetic resonance imaging (qMRI) technique that has emerged as a valuable tool in the diagnosis of diffuse myocardial diseases. However, prevailing approaches have relied heavily on breath-hold sequences to…