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Functional magnetic resonance imaging (fMRI) data have become increasingly available and are useful for describing functional connectivity (FC), the relatedness of neuronal activity in regions of the brain. This FC of the brain provides…

Machine Learning · Statistics 2020-10-14 Andrew DiLernia , Karina Quevedo , Jazmin Camchong , Kelvin Lim , Wei Pan , Lin Zhang

Segmentation of Multiple Sclerosis (MS) lesions in longitudinal brain MR scans is performed for monitoring the progression of MS lesions. We hypothesize that the spatio-temporal cues in longitudinal data can aid the segmentation algorithm.…

Image and Video Processing · Electrical Eng. & Systems 2020-09-29 Stefan Denner , Ashkan Khakzar , Moiz Sajid , Mahdi Saleh , Ziga Spiclin , Seong Tae Kim , Nassir Navab

This work has been carried out to improve the dearth of high-quality EEG datasets used for schizophrenia diagnostic tools development and studies from populations of developing and underdeveloped regions of the world. To this aim, the…

Neural and Evolutionary Computing · Computer Science 2024-01-23 E. O. Olateju , K. P. Ayodele , S. K. Mosaku

Identifying objective neuroimaging biomarkers to forecast Alzheimer's disease (AD) progression is crucial for timely intervention. However, this task remains challenging due to the complex dysfunctions in the spatio-temporal characteristics…

Major Depressive Disorder (MDD) is a highly prevalent mental health condition, and a deeper understanding of its neurocognitive foundations is essential for identifying how core functions such as emotional and self-referential processing…

Longitudinal assessment of brain atrophy, particularly in the hippocampus, is a well-studied biomarker for neurodegenerative diseases, such as Alzheimer's disease (AD). In clinical trials, estimation of brain progressive rates can be…

Neurons and Cognition · Quantitative Biology 2023-04-11 Mengjin Dong , Long Xie , Sandhitsu R. Das , Jiancong Wang , Laura E. M. Wisse , Robin deFlores , David A. Wolk , Paul A. Yushkevich

Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key evidence from neuroimaging data for pathological commonness remains unrevealed. To explore this hypothesis,…

Artificial Intelligence · Computer Science 2023-02-24 Mianxin Liu , Jingyang Zhang , Yao Wang , Yan Zhou , Fang Xie , Qihao Guo , Feng Shi , Han Zhang , Qian Wang , Dinggang Shen

Alzheimer's Disease and Related Dementias (AD/ADRD) are progressive neurodegenerative conditions that impair memory, thought processes, and functioning. Family caregivers of individuals with AD/ADRD face significant mental health challenges…

Human-Computer Interaction · Computer Science 2025-11-04 Jiayue Melissa Shi , Keran Wang , Dong Whi Yoo , Ravi Karkar , Koustuv Saha

Many neurological diseases are characterized by gradual deterioration of brain structure and function. Large longitudinal MRI datasets have revealed such deterioration, in part, by applying machine and deep learning to predict diagnosis. A…

Image and Video Processing · Electrical Eng. & Systems 2021-05-27 Jiahong Ouyang , Qingyu Zhao , Edith V Sullivan , Adolf Pfefferbaum , Susan F. Tapert , Ehsan Adeli , Kilian M Pohl

Alzheimer's Disease (AD) is a progressive neurodegenerative disease. Amnestic mild cognitive impairment (MCI) is a common first symptom before the conversion to clinical impairment where the individual becomes unable to perform activities…

Computer Vision and Pattern Recognition · Computer Science 2017-10-16 Donghuan Lu , Karteek Popuri , Weiguang Ding , Rakesh Balachandar , Mirza Faisal Beg

I present a theory of schizophrenia (SZ) that mechanistically explains its etiology, symptoms, pathophysiology, and treatment. SZ involves the chronic release of membrane polyunsaturated fatty acids (PUFAs) and their utilization for the…

Neurons and Cognition · Quantitative Biology 2024-08-14 Ari Rappoport

Chronic subdural hematoma (cSDH) is a common neurological condition characterized by the accumulation of blood between the brain and the dura mater. This accumulation of blood can exert pressure on the brain, potentially leading to fatal…

Image and Video Processing · Electrical Eng. & Systems 2024-03-29 Baris Imre , Elina Thibeau-Sutre , Jorieke Reimer , Kuan Kho , Jelmer M. Wolterink

Neurodiversity describes variation in brain function among people, including common conditions such as Autism spectrum disorder (ASD), Attention deficit hyperactivity disorder (ADHD), and dyslexia. While Software Engineering (SE) literature…

Software Engineering · Computer Science 2025-06-05 Pragya Verma , Marcos Vinicius Cruz , Grischa Liebel

Introduction Schizophrenia is a severe mental disorder, and early diagnosis is key to improving outcomes. Its complexity makes predicting onset and progression challenging. EEG has emerged as a valuable tool for studying schizophrenia, with…

Signal Processing · Electrical Eng. & Systems 2024-10-29 Gideon Vos , Maryam Ebrahimpour , Liza van Eijk , Zoltan Sarnyai , Mostafa Rahimi Azghadi

Contemporary neuroimaging methods can shed light on the basis of human neural and cognitive specializations, with important implications for neuroscience and medicine. Different MRI acquisitions provide different brain networks at the…

Neurons and Cognition · Quantitative Biology 2016-02-23 C. Alonso-Montes , I. Diez , L. Remaki , I. Escudero , B. Mateos , Y. Rosseel , D. Marinazzo , S. Stramaglia , J. Cortes

The human brain is a directional network system of brain regions involving directional connectivity. Seizures are a directional network phenomenon as abnormal neuronal activities start from a seizure onset zone (SOZ) and propagate to…

Schizophrenia (SZ) is a complex mental disorder that necessitates accurate and timely diagnosis for effective treatment. Traditional methods for SZ classification often struggle to capture transient EEG features and face high computational…

Signal Processing · Electrical Eng. & Systems 2024-07-26 Umesh Kumar Naik M , Shaik Rafi Ahamed

Studies on schizophrenia assessments using deep learning typically treat it as a classification task to detect the presence or absence of the disorder, oversimplifying the condition and reducing its clinical applicability. This traditional…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-29 Gowtham Premananth , Philip Resnik , Sonia Bansal , Deanna L. Kelly , Carol Espy-Wilson

Electroencephalography (EEG) has been widely used to study the relationship between naps and working memory, yet the effects of naps on distinct working memory tasks remain unclear. Here, participants performed word-pair and visuospatial…

Neurons and Cognition · Quantitative Biology 2023-11-16 Gi-Hwan Shin , Young-Seok Kweon , Heon-Gyu Kwak , Ha-Na Jo , Seong-Whan Lee

[See full abstract in the pdf] Formal Thought Disorder (FTD), which is a group of symptoms in cognition that affects language and thought, can be observed through language. FTD is seen across such developmental or psychiatric disorders as…

Computation and Language · Computer Science 2023-10-17 Takeshi Saga , Hiroki Tanaka , Satoshi Nakamura