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Epidemiologic and genetic studies in chronic obstructive pulmonary disease (COPD) and many complex diseases suggest subgroup disparities (e.g., by sex). We consider this problem from the standpoint of integrative analysis where we combine…

Methodology · Statistics 2023-09-26 J. Butts , C. Wendt , R. Bowler , C. P. Hersh , Q. Long , L. Eberly , S. E. Safo

The package mvlearnR and accompanying Shiny App is intended for integrating data from multiple sources or views or modalities (e.g. genomics, proteomics, clinical and demographic data). Most existing software packages for multiview learning…

Genomics · Quantitative Biology 2023-11-29 Elise F. Palzer , Sandra E. Safo

Recent advances in AI for science have highlighted the power of contrastive learning in bridging heterogeneous biological data modalities. Building on this paradigm, we propose HIPPO (HIerarchical Protein-Protein interaction prediction…

Machine Learning · Computer Science 2025-08-05 Shiyi Liu , Buwen Liang , Yuetong Fang , Zixuan Jiang , Renjing Xu

Predicting user influence in social networks is a critical problem, and hypergraphs, as a prevalent higher-order modeling approach, provide new perspectives for this task. However, the absence of explicit cascade or infection probability…

Social and Information Networks · Computer Science 2025-08-22 Su-Su Zhang , JinFeng Xie , Yang Chen , Min Gao , Cong Li , Chuang Liu , Xiu-Xiu Zhan

This paper proposes a Heaviside composite optimization approach and presents a progressive (mixed) integer programming (PIP) method for solving multi-class classification and multi-action treatment problems with constraints. A Heaviside…

Optimization and Control · Mathematics 2024-01-08 Yue Fang , Junyi Liu , Jong-Shi Pang

We propose Bayesian Hierarchical Invariant Prediction (BHIP) reframing Invariant Causal Prediction (ICP) through the lens of Hierarchical Bayes. We leverage the hierarchical structure to explicitly test invariance of causal mechanisms under…

In the era of big data, large-scale, multi-source, multi-modality datasets are increasingly ubiquitous, offering unprecedented opportunities for predictive modeling and scientific discovery. However, these datasets often exhibit complex…

Machine Learning · Computer Science 2025-12-10 Qi Xu , Annie Qu

Pro-inflammatory peptides (PIPs) play critical roles in immune signaling and inflammation but are difficult to identify experimentally due to costly and time-consuming assays. To address this challenge, we present KEMP-PIP, a hybrid machine…

Quantitative Methods · Quantitative Biology 2026-02-25 Soumik Deb Niloy , Md. Fahmid-Ul-Alam Juboraj , Swakkhar Shatabda

We propose a novel online multi-target visual tracker based on the recently developed Hypothesized and Independent Stochastic Population (HISP) filter. The HISP filter combines advantages of traditional tracking approaches like MHT and…

Computer Vision and Pattern Recognition · Computer Science 2020-10-13 Nathanael L. Baisa

Depression and anxiety are critical public health issues affecting millions of people around the world. To identify individuals who are vulnerable to depression and anxiety, predictive models have been built that typically utilize data from…

Social and Information Networks · Computer Science 2020-01-14 Shikang Liu , Fatemeh Vahedian , David Hachen , Omar Lizardo , Christian Poellabauer , Aaron Striegel , Tijana Milenkovic

Subgroup analysis of treatment effects plays an important role in applications from medicine to public policy to recommender systems. It allows physicians (for example) to identify groups of patients for whom a given drug or treatment is…

Machine Learning · Statistics 2020-10-20 Hyun-Suk Lee , Yao Zhang , William Zame , Cong Shen , Jang-Won Lee , Mihaela van der Schaar

This article presents a study that uses multiple linear regression analysis to examine the factors influencing the number of people affiliated with different insurance plans within the Comprehensive Health Insurance (SIS) system in Peru.The…

Other Statistics · Statistics 2023-08-06 Nadine ACeituno-Moya , Fred Torres-Cruz

End-to-end visual information extraction (VIE) aims at integrating the hierarchical subtasks of VIE, including text spotting, word grouping, and entity labeling, into a unified framework. Dealing with the gaps among the three subtasks plays…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Rujiao Long , Pengfei Wang , Zhibo Yang , Cong Yao

As a powerful representation paradigm for networked and multi-typed data, the heterogeneous information network (HIN) is ubiquitous. Meanwhile, defining proper relevance measures has always been a fundamental problem and of great pragmatic…

Social and Information Networks · Computer Science 2019-02-22 Yu Shi , Po-Wei Chan , Honglei Zhuang , Huan Gui , Jiawei Han

We introduce hyppo, a unified library for performing multivariate hypothesis testing, including independence, two-sample, and k-sample testing. While many multivariate independence tests have R packages available, the interfaces are…

Contrastive Language-Image Pre-training (CLIP) has become the standard for cross-modal image-text representation learning. Improving CLIP typically requires additional data and retraining with new loss functions, but these demands raise…

Computer Vision and Pattern Recognition · Computer Science 2025-02-10 Haonan Wang , Minbin Huang , Runhui Huang , Lanqing Hong , Hang Xu , Tianyang Hu , Xiaodan Liang , Zhenguo Li , Hong Cheng , Kenji Kawaguchi

Clinical research often focuses on complex traits in which many variables play a role in mechanisms driving, or curing, diseases. Clinical prediction is hard when data is high-dimensional, but additional information, like domain knowledge…

Methodology · Statistics 2020-05-21 Mirrelijn M. van Nee , Lodewyk F. A. Wessels , Mark A. van de Wiel

Effectively medication recommendation with complex multimorbidity conditions is a critical task in healthcare. Most existing works predicted medications based on longitudinal records, which assumed the information transmitted patterns of…

Machine Learning · Computer Science 2023-09-13 Sicen Liu , Xiaolong Wang , JIngcheng Du , Yongshuai Hou , Xianbing Zhao , Hui Xu , Hui Wang , Yang Xiang , Buzhou Tang

Integrating multiple observational studies for meta-analysis has sparked much interest. The presented R package WMAP (Weighted Meta-Analysis with Pseudo-Population) addresses a critical gap in the implementation of integrative weighting…

Methodology · Statistics 2025-07-01 Subharup Guha , Mengqi Xu , Kashish Priyam , Yi Li

Evidence-based decision making often relies on meta-analyzing multiple studies, which enables more precise estimation and investigation of generalizability. Integrative analysis of multiple heterogeneous studies is, however, highly…

Methodology · Statistics 2020-09-15 Tianxi Cai , Molei Liu , Yin Xia
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