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In eukaryotic cell chemotaxis, cells extend and retract transient actin-driven protrusions at their membrane that facilitate both the detection of external chemical gradients and directional movement via the formation of focal adhesions…

Cell Behavior · Quantitative Biology 2025-09-25 Samuel W. S. Johnson , Maddy Parsons , Ruth E. Baker , Philip K. Maini

The phase transition kinetics in three phase systems was investigated using the numerically efficient cell dynamics method. A phasefield model with a simple analytical free energy and single order parameter was used to study the kinetics…

Materials Science · Physics 2010-03-23 Masao Iwamatsu

Systems of independent active particles embedded into a fluctuating environment are relevant to many areas of soft-matter science. We use a minimal model of noninteracting spin-carrying Brownian particles in a Gaussian field and show that…

Soft Condensed Matter · Physics 2018-07-18 Ruben Zakine , Jean-Baptiste Fournier , Frédéric Van Wijland

We introduce a new model of aggregation of particles where in addition to diffusion and aggregation upon contact, a single unit of mass can dissociate from a conglomerate. This dissociation move conserves the total mass and leads to a…

Statistical Mechanics · Physics 2008-02-03 Supriya Krishnamurthy , Satya N. Majumdar , Mustansir Barma

Cell spreading requires a major reorganisation of the actin cytoskeleton, from a cortical structure to a lamellipodium where filaments are mostly parallel to the substrate. We propose a model inspired by the physics of nematic liquid…

Biological Physics · Physics 2019-06-07 Mathieu Dedenon , Pierre Sens

Phase field crystal (PFC) models constitute a field theoretical approach to solidification, melting and related phenomena at atomic length and diffusive time scales. One of the advantages of these models is that they naturally contain…

Materials Science · Physics 2015-06-18 V. Heinonen , C. V. Achim , K. R. Elder , S. Buyukdagli , T. Ala-Nissila

Migration of animal cells is based on the interplay between actin polymerization at the front, adhesion along the cell-substrate interface, and actomyosin contractility at the back. Active gel theory has been used before to demonstrate that…

Cell Behavior · Quantitative Biology 2024-12-11 Valentin Wössner , Oliver M. Drozdowski , Falko Ziebert , Ulrich S. Schwarz

We derive the amplitude expansion for a phase-field-crystal (APFC) model that captures the basic physics of magneto-structural interactions. The symmetry breaking due to magnetization is demonstrated, and the characterization of the…

Materials Science · Physics 2023-01-02 Rainer Backofen , Marco Salvalaglio , Axel Voigt

We discuss a theoretical model for the cooperative binding dynamics of tropomyosin to actin filaments. Tropomyosin binds to actin by occupying seven consecutive monomers. The model includes a strong attraction between attached tropomyosin…

Soft Condensed Matter · Physics 2009-11-07 Andrej Vilfan

Many biological systems consist of self-motile and passive agents both of which contribute to overall functionality. However, there are very few studies of the properties of such mixtures. Here we formulate a model for mixtures of…

Soft Condensed Matter · Physics 2015-05-25 Denis F. Hinz , Alexander Panchenko , Tae-Yeon Kim , Eliot Fried

Actomyosin networks are major structural components of the cell. They provide mechanical integrity and allow dynamic remodeling of eukaryotic cells, self-organizing into the diverse patterns essential for development. We provide a…

Biological Physics · Physics 2012-04-17 Shenshen Wang , Peter G. Wolynes

The nucleus of eukaryotic cells typically makes up around 30% of the cell volume and has significantly different mechanics, which can make it effectively up to ten times stiffer than the surrounding cytoplasm. Therefore it is an important…

Soft Condensed Matter · Physics 2024-03-27 Robert Chojowski , Ulrich S. Schwarz , Falko Ziebert

Cortical actin networks are highly dynamic and play critical roles in shaping the mechanical properties of cells. The actin cytoskeleton undergoes significant reorganization over the course of the cell cycle, when cortical actin transitions…

Quantitative Methods · Quantitative Biology 2022-07-22 Maria-Veronica Ciocanel , Aravind Chandrasekaran , Carli Mager , Qin Ni , Garegin Papoian , Adriana Dawes

We investigate the structural and thermodynamic properties of a model of particles with $2$ patches of type $A$ and $10$ patches of type $B$. Particles are placed on the sites of a face centered cubic lattice with the patches oriented along…

Soft Condensed Matter · Physics 2015-06-18 J. M. Tavares , N. G. Almarza , M. M. Telo da Gama

We consider model of a complex particle that consists of a rigid shell and a nucleus with spatial asymmetric interaction. The particle's dynamics with the nucleus driven by a periodic excitation is considered. It is shown that…

Chaotic Dynamics · Physics 2007-05-23 Sergey Denisov

We consider the problem of heterogeneous nucleation and growth. The system is described by a phase field model in which the temperature is included through thermal noise. We show that this phase field approach is suitable to describe…

Statistical Mechanics · Physics 2009-11-07 Mario Castro

The essential features of the in vitro refolding of myoglobin are expressed in a solvable physical model. Alpha helices are taken as the fundamental collective coordinates of the system, while the refolding is assumed to be mainly driven by…

Condensed Matter · Physics 2007-05-23 David J. E. Callaway

We study nonequilibrium phase transitions of reaction-diffusion systems defined on randomly diluted lattices, focusing on the transition across the lattice percolation threshold. To develop a theory for this transition, we combine classical…

Statistical Mechanics · Physics 2009-04-27 Man Young Lee , Thomas Vojta

Interface energy and kinetic coefficient of crystal growth strongly depend on the face of the crystalline lattice. To investigate the kinetic anisotropy and velocity of different crystallographic faces we use the hyperbolic (modified) phase…

Materials Science · Physics 2020-04-03 Vladimir Ankudinov , Peter K. Galenko

The actin cytoskeleton is a semiflexible biopolymer network whose morphology is controlled by a wide range of biochemical and physical factors. Actin is known to undergo a phase transition from a single-filament state to a bundled state by…