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Medical image artificial intelligence models often achieve strong performance in single-center or single-device settings, yet their effectiveness frequently deteriorates in real-world cross-center deployment due to domain shift, limiting…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Jingsong Xia , Siqi Wang

Deep learning models exhibit limited generalizability across different domains. Specifically, transferring knowledge from available entangled domain features(source/target domain) and categorical features to new unseen categorical features…

Computer Vision and Pattern Recognition · Computer Science 2020-03-03 Qingjie Meng , Daniel Rueckert , Bernhard Kainz

Electroencephalography (EEG) is shown to be a valuable data source for evaluating subjects' mental states. However, the interpretation of multi-modal EEG signals is challenging, as they suffer from poor signal-to-noise-ratio, are highly…

Signal Processing · Electrical Eng. & Systems 2022-04-19 David Bethge , Philipp Hallgarten , Ozan Özdenizci , Ralf Mikut , Albrecht Schmidt , Tobias Grosse-Puppendahl

When machine learning models are deployed on a test distribution different from the training distribution, they can perform poorly, but overestimate their performance. In this work, we aim to better estimate a model's performance under…

Machine Learning · Computer Science 2020-07-08 Ching-Yao Chuang , Antonio Torralba , Stefanie Jegelka

A deep learning model trained on some labeled data from a certain source domain generally performs poorly on data from different target domains due to domain shifts. Unsupervised domain adaptation methods address this problem by alleviating…

Image and Video Processing · Electrical Eng. & Systems 2019-08-30 Junlin Yang , Nicha C. Dvornek , Fan Zhang , Julius Chapiro , MingDe Lin , James S. Duncan

In many machine learning domains, datasets are characterized by highly imbalanced and overlapping classes. Particularly in the medical domain, a specific list of symptoms can be labeled as one of various different conditions. Some of these…

Machine Learning · Computer Science 2020-06-03 Ran Ilan Ber , Tom Haramaty

Domain generalization refers to the problem where we aim to train a model on data from a set of source domains so that the model can generalize to unseen target domains. Naively training a model on the aggregate set of data (pooled from all…

Machine Learning · Computer Science 2022-02-16 A. Tuan Nguyen , Toan Tran , Yarin Gal , Atılım Güneş Baydin

The success of supervised learning hinges on the assumption that the training and test data come from the same underlying distribution, which is often not valid in practice due to potential distribution shift. In light of this, most…

Machine Learning · Computer Science 2021-04-06 Bo Li , Yezhen Wang , Shanghang Zhang , Dongsheng Li , Trevor Darrell , Kurt Keutzer , Han Zhao

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro…

Machine Learning · Computer Science 2026-03-18 Camille Jimenez Cortes , Philippe Lalanda , German Vega

The foremost challenge to causal inference with real-world data is to handle the imbalance in the covariates with respect to different treatment options, caused by treatment selection bias. To address this issue, recent literature has…

Machine Learning · Statistics 2022-02-23 Zhixuan Chu , Stephen Rathbun , Sheng Li

Clinical data is often affected by clinically irrelevant factors such as discrepancies between measurement devices or differing processing methods between sites. In the field of machine learning (ML), these factors are known as domains and…

Deep learning-based methods deliver state-of-the-art performance for solving inverse problems that arise in computational imaging. These methods can be broadly divided into two groups: (1) learn a network to map measurements to the signal…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 Nebiyou Yismaw , Ulugbek S. Kamilov , M. Salman Asif

With the successful adoption of machine learning on electronic health records (EHRs), numerous computational models have been deployed to address a variety of clinical problems. However, due to the heterogeneity of EHRs, models trained on…

Machine Learning · Computer Science 2021-01-14 Yiqin Yu , Pin-Yu Chen , Yuan Zhou , Jing Mei

Machine learning techniques used in computer-aided medical image analysis usually suffer from the domain shift problem caused by different distributions between source/reference data and target data. As a promising solution, domain…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Hao Guan , Mingxia Liu

Deep learning has shown remarkable progress in medical image semantic segmentation, yet its success heavily depends on large-scale expert annotations and consistent data distributions. In practice, annotations are scarce, and images are…

Computer Vision and Pattern Recognition · Computer Science 2026-01-26 Ba-Thinh Lam , Thanh-Huy Nguyen , Hoang-Thien Nguyen , Quang-Khai Bui-Tran , Nguyen Lan Vi Vu , Phat K. Huynh , Ulas Bagci , Min Xu

In the problem of domain transfer learning, we learn a model for the predic-tion in a target domain from the data of both some source domains and the target domain, where the target domain is in lack of labels while the source domain has…

Computer Vision and Pattern Recognition · Computer Science 2018-05-21 Guohui Zhang , Gaoyuan Liang , Fang Su , Fanxin Qu , Jing-Yan Wang

In recent years, deep learning-based feature representation methods have shown a promising impact in electroencephalography (EEG)-based brain-computer interface (BCI). Nonetheless, owing to high intra- and inter-subject variabilities, many…

Machine Learning · Computer Science 2020-08-24 Eunjin Jeon , Wonjun Ko , Jee Seok Yoon , Heung-Il Suk

Despite the impressive advances achieved using deep learning for functional brain activity analysis, the heterogeneity of functional patterns and the scarcity of imaging data still pose challenges in tasks such as identifying neurological…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Wenhui Cui , Haleh Akrami , Anand A. Joshi , Richard M. Leahy

Continual learning (CL) aims to train models sequentially over multiple domains without forgetting previously learned knowledge. However, existing CL methods optimize for in-domain performance and are therefore prone to learning spurious,…

Machine Learning · Computer Science 2026-05-18 Pascal Janetzky , Tobias Schlagenhauf , Stefan Feuerriegel

Deep learning has achieved remarkable success in medical image classification. However, its clinical application is often hindered by data heterogeneity caused by variations in scanner vendors, imaging protocols, and operators. Approaches…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Yaoyao Zhu , Xiuding Cai , Yingkai Wang , Yu Yao , Xu Luo , Zhongliang Fu