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Light microscopy is a widespread and inexpensive imaging technique facilitating biomedical discovery and diagnostics. However, light diffraction barrier and imperfections in optics limit the level of detail of the acquired images. The…

Quantitative Methods · Quantitative Biology 2026-03-24 Rui Li , Gabriel della Maggiora , Vardan Andriasyan , Anthony Petkidis , Artsemi Yushkevich , Mikhail Kudryashev , Artur Yakimovich

Time-resolved high-resolution X-ray Computed Tomography (4D $\mu$CT) is an imaging technique that offers insight into the evolution of dynamic processes inside materials that are opaque to visible light. Conventional tomographic…

Image and Video Processing · Electrical Eng. & Systems 2026-01-12 Wannes Goethals , Tom Bultreys , Steffen Berg , Matthieu N. Boone , Jan Aelterman

X-ray computed tomography (CT) based on photon counting detectors (PCD) extends standard CT by counting detected photons in multiple energy bins. PCD data can be used to increase the contrast-to-noise ratio (CNR), increase spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-02-05 Natalie M. Jadue , Madhuri Nagare , Jonathan S. Maltz , Gregery T. Buzzard , Charles A. Bouman

Computed tomography (CT) is routinely used for three-dimensional non-invasive imaging. Numerous data-driven image denoising algorithms were proposed to restore image quality in low-dose acquisitions. However, considerably less research…

Medical imaging is playing a more and more important role in clinics. However, there are several issues in different imaging modalities such as slow imaging speed in MRI, radiation injury in CT and PET. Therefore, accelerating MRI, reducing…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Jing Cheng , Haifeng Wang , Yanjie Zhu , Qiegen Liu , Qiyang Zhang , Ting Su , Jianwei Chen , Yongshuai Ge , Zhanli Hu , Xin Liu , Hairong Zheng , Leslie Ying , Dong Liang

This work presents TV-LoRA, a novel method for low-dose sparse-view CT reconstruction that combines a diffusion generative prior (NCSN++ with SDE modeling) and multi-regularization constraints, including anisotropic TV and nuclear norm…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Zongyin Deng , Qing Zhou , Yuhao Fang , Zijian Wang , Yao Lu , Ye Zhang , Chun Li

Low dose CT is of great interest in these days. Dose reduction raises noise level in projections and decrease image quality in reconstructions. Model based image reconstruction can combine statistical noise model together with prior…

Medical Physics · Physics 2019-10-16 Kaichao Liang , Li Zhang , Yirong Yang , HongKai Yang , Yuxiang Xing

Combining dual-energy computed tomography (DECT) with positron emission tomography (PET) offers many potential clinical applications but typically requires expensive hardware upgrades or increases radiation doses on PET/CT scanners due to…

Medical Physics · Physics 2024-06-21 Siqi Li , Yansong Zhu , Benjamin A. Spencer , Guobao Wang

Computed tomography (CT) is one of the modalities for effective lung cancer screening, diagnosis, treatment, and prognosis. The features extracted from CT images are now used to quantify spatial and temporal variations in tumors. However,…

Image and Video Processing · Electrical Eng. & Systems 2023-03-28 Md Selim , Jie Zhang , Michael A. Brooks , Ge Wang , Jin Chen

We introduce a new CT image reconstruction algorithm that is less affected by various artifacts. The new reconstruction algorithm is a method of minimizing the difference between synchrotron X-ray tomography data and sinograms generated…

Medical Physics · Physics 2021-11-22 Byung Chun Kim , Hyunju Lee , Kyungtaek Jun

While Computerized Tomography (CT) images can help detect disease such as Covid-19, regular CT machines are large and expensive. Cheaper and more portable machines suffer from errors in geometry acquisition that downgrades CT image quality.…

Image and Video Processing · Electrical Eng. & Systems 2021-08-03 Peijian Ding

Computed tomography (CT) is widely used in scientific imaging systems such as synchrotron and laboratory-based nano-CT, but acquiring full-view sinograms requires high radiation dose and long scan times. Sparse-view CT reduces this burden…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Jiaze E , Srutarshi Banerjee , Tekin Bicer , Guannan Wang , Yanfu Zhang , Bin Ren

Computed Tomography (CT) with its remarkable capability for three-dimensional imaging from multiple projections, enjoys a broad range of applications in clinical diagnosis, scientific observation, and industrial detection. Neural Adaptive…

Image and Video Processing · Electrical Eng. & Systems 2023-11-06 Bo Xiong , Changqing Su , Zihan Lin , You Zhou , Zhaofei Yu

In this paper, we investigate image reconstruction for dynamic Computed Tomography. The motion of the target with respect to the measurement acquisition rate leads to highly resolved in time but highly undersampled in space measurements.…

Image and Video Processing · Electrical Eng. & Systems 2025-06-27 Pablo Arratia , Matthias Ehrhardt , Lisa Kreusser

Computed Tomography (CT) scans are the standard-of-care for the visualization and diagnosis of many clinical ailments, and are needed for the treatment planning of external beam radiotherapy. Unfortunately, the availability of CT scanners…

Image and Video Processing · Electrical Eng. & Systems 2024-08-28 Yiran Sun , Hana Baroudi , Tucker Netherton , Laurence Court , Osama Mawlawi , Ashok Veeraraghavan , Guha Balakrishnan

Low-dose computed tomography (LDCT) aims to minimize the radiation exposure to patients while maintaining diagnostic image quality. However, traditional CT reconstruction algorithms often struggle with the ill-posed nature of the problem,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-17 Daisy Chen

Diffusion models have recently gained traction as a powerful class of deep generative priors, excelling in a wide range of image restoration tasks due to their exceptional ability to model data distributions. To solve image restoration…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Xiang Li , Soo Min Kwon , Shijun Liang , Ismail R. Alkhouri , Saiprasad Ravishankar , Qing Qu

Reconstructing a dynamic object with affine motion in computerized tomography (CT) leads to motion artifacts if the motion is not taken into account. In most cases, the actual motion is neither known nor can be determined easily. As a…

Numerical Analysis · Mathematics 2024-03-14 Gesa Sarnighausen , Anne Wald , Alexander Meaney

Despite the indispensable role of X-ray computed tomography (CT) in diagnostic medicine field, the associated ionizing radiation is still a major concern considering that it may cause genetic and cancerous diseases. Decreasing the exposure…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Ti Bai , Dan Nguyen , Biling Wang , Steve Jiang

This paper concerns iterative reconstruction for low-dose and few-view CT by minimizing a data-fidelity term regularized with the Total Variation (TV) penalty. We propose a very fast iterative algorithm to solve this problem. The algorithm…

Medical Physics · Physics 2017-02-01 Hiroyuki Kudo , Fukashi Yamazaki , Takuya Nemoto , Keita Takaki