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Related papers: Latent Diffusion Model for DNA Sequence Generation

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Discrete diffusion models are a powerful, emerging paradigm for code generation. They construct programs through iterative refinement of partially corrupted token sequences and enable parallel token refinement. Importantly, this paradigm…

Computation and Language · Computer Science 2026-05-19 Lize Shao , Michael Cardei , Zichen Xie , Ferdinando Fioretto , Wenxi Wang

Designing protein binders targeting specific sites, which requires to generate realistic and functional interaction patterns, is a fundamental challenge in drug discovery. Current structure-based generative models are limited in generating…

Machine Learning · Computer Science 2025-10-17 Zishen Zhang , Xiangzhe Kong , Wenbing Huang , Yang Liu

The recent developments of Diffusion Models (DMs) enable generation of astonishingly high-quality synthetic samples. Recent work showed that the synthetic samples generated by the diffusion model, which is pre-trained on public data and…

Machine Learning · Computer Science 2024-06-11 Jing Liu , Andrew Lowy , Toshiaki Koike-Akino , Kieran Parsons , Ye Wang

Over the past decade, there has been tremendous progress in creating synthetic media, mainly thanks to the development of powerful methods based on generative adversarial networks (GAN). Very recently, methods based on diffusion models (DM)…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Riccardo Corvi , Davide Cozzolino , Giada Zingarini , Giovanni Poggi , Koki Nagano , Luisa Verdoliva

Face recognition systems have significantly advanced in recent years, driven by the availability of large-scale datasets. However, several issues have recently came up, including privacy concerns that have led to the discontinuation of…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Pietro Melzi , Christian Rathgeb , Ruben Tolosana , Ruben Vera-Rodriguez , Dominik Lawatsch , Florian Domin , Maxim Schaubert

By embedding discrete representations into a continuous latent space, we can leverage continuous-space latent diffusion models to handle generative modeling of discrete data. However, despite their initial success, most latent diffusion…

Machine Learning · Computer Science 2025-04-02 Bac Nguyen , Chieh-Hsin Lai , Yuhta Takida , Naoki Murata , Toshimitsu Uesaka , Stefano Ermon , Yuki Mitsufuji

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2017-10-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Generative Adversarial Networks (GANs) are proficient at generating synthetic data but continue to suffer from mode collapse, where the generator produces a narrow range of outputs that fool the discriminator but fail to capture the full…

Machine Learning · Computer Science 2025-11-03 Mahsa Valizadeh , Rui Tuo , James Caverlee

We introduce the DP-auto-GAN framework for synthetic data generation, which combines the low dimensional representation of autoencoders with the flexibility of Generative Adversarial Networks (GANs). This framework can be used to take in…

Machine Learning · Computer Science 2020-12-11 Uthaipon Tantipongpipat , Chris Waites , Digvijay Boob , Amaresh Ankit Siva , Rachel Cummings

Diffusion models excel at capturing the natural design spaces of images, molecules, DNA, RNA, and protein sequences. However, rather than merely generating designs that are natural, we often aim to optimize downstream reward functions while…

Accurately identifying oocytes that progress to the blastocyst stage is crucial in reproductive medicine, but the limited availability of annotated high-quality embryo images presents challenges for developing automated diagnostic tools. To…

Quantitative Methods · Quantitative Biology 2025-06-18 Alejandro Golfe , Natalia P. García-de-la-puente , Adrián Colomer , Valery Naranjo

Medical image segmentation models struggle with rare abnormalities due to scarce annotated pathological data. We propose DiffAug a novel framework that combines textguided diffusion-based generation with automatic segmentation validation to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Maham Nazir , Muhammad Aqeel , Francesco Setti

As a new way of training generative models, Generative Adversarial Nets (GAN) that uses a discriminative model to guide the training of the generative model has enjoyed considerable success in generating real-valued data. However, it has…

Machine Learning · Computer Science 2017-08-28 Lantao Yu , Weinan Zhang , Jun Wang , Yong Yu

The paradigm shift toward structure-driven molecule generation has been propelled by advances in deep generative models, such as variational auto-encoders and diffusion models. However, these generative models for molecular design remain…

Machine Learning · Computer Science 2026-04-17 Peidong Liu , Wenbo Zhang , Wei Ju , Jiancheng Lv , Xianggen Liu

We introduce TransDiff, the first image generation model that marries Autoregressive (AR) Transformer with diffusion models. In this joint modeling framework, TransDiff encodes labels and images into high-level semantic features and employs…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Dingcheng Zhen , Qian Qiao , Xu Zheng , Tan Yu , Kangxi Wu , Ziwei Zhang , Siyuan Liu , Shunshun Yin , Ming Tao

The rapid advancement of generative artificial intelligence has enabled the creation of highly realistic fake facial images, posing serious threats to personal privacy and the integrity of online information. Existing deepfake detection…

Computer Vision and Pattern Recognition · Computer Science 2025-12-29 Huanhuan Yuan , Yang Ping , Zhengqin Xu , Junyi Cao , Shuai Jia , Chao Ma

The Diffusion Probabilistic Model (DPM) has emerged as a highly effective generative model in the field of computer vision. Its intermediate latent vectors offer rich semantic information, making it an attractive option for various…

Computer Vision and Pattern Recognition · Computer Science 2023-03-29 Haipeng Zhou , Lei Zhu , Yuyin Zhou

This paper aims to conduct a comprehensive theoretical analysis of current diffusion models. We introduce a novel generative learning methodology utilizing the Schr{\"o}dinger bridge diffusion model in latent space as the framework for…

Machine Learning · Statistics 2024-12-24 Yuling Jiao , Lican Kang , Huazhen Lin , Jin Liu , Heng Zuo

This paper presents a novel method for analyzing the latent space geometry of generative models, including statistical physics models and diffusion models, by reconstructing the Fisher information metric. The method approximates the…

Machine Learning · Computer Science 2025-06-13 Alexander Lobashev , Dmitry Guskov , Maria Larchenko , Mikhail Tamm

Diffusion models (DMs) are one of the most widely used generative models for producing high quality images. However, a flurry of recent papers points out that DMs are least private forms of image generators, by extracting a significant…

Machine Learning · Statistics 2025-03-06 Michael F. Liu , Saiyue Lyu , Margarita Vinaroz , Mijung Park