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The wide-spread adoption of representation learning technologies in clinical decision making strongly emphasizes the need for characterizing model reliability and enabling rigorous introspection of model behavior. While the former need is…

Machine Learning · Computer Science 2020-05-01 Jayaraman J. Thiagarajan , Prasanna Sattigeri , Deepta Rajan , Bindya Venkatesh

Automated skin lesion classification using deep learning has shown remarkable accuracy, yet clinical adoption remains limited due to the "black box" nature of these models. We present MelanomaNet, an explainable deep learning system for…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Sukhrobbek Ilyosbekov

Medical Vision-Language Models (MVLMs) have achieved par excellence generalization in medical image analysis, yet their performance under noisy, corrupted conditions remains largely untested. Clinical imaging is inherently susceptible to…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Raza Imam , Rufael Marew , Mohammad Yaqub

The analysis of vision-based deep neural networks (DNNs) is highly desirable but it is very challenging due to the difficulty of expressing formal specifications for vision tasks and the lack of efficient verification procedures. In this…

Machine Learning · Computer Science 2024-04-12 Ravi Mangal , Nina Narodytska , Divya Gopinath , Boyue Caroline Hu , Anirban Roy , Susmit Jha , Corina Pasareanu

Recent work has found that adversarially-robust deep networks used for image classification are more interpretable: their feature attributions tend to be sharper, and are more concentrated on the objects associated with the image's…

Machine Learning · Computer Science 2021-10-07 Zifan Wang , Matt Fredrikson , Anupam Datta

Concept bottleneck models (CBMs) improve neural network interpretability by introducing an intermediate layer that maps human-understandable concepts to predictions. Recent work has explored the use of vision-language models (VLMs) to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Xingbo Du , Qiantong Dou , Lei Fan , Rui Zhang

Understanding how a complex machine learning model makes a classification decision is essential for its acceptance in sensitive areas such as health care. Towards this end, we present PatchNet, a method that provides the features indicative…

Computer Vision and Pattern Recognition · Computer Science 2018-12-03 Adityanarayanan Radhakrishnan , Charles Durham , Ali Soylemezoglu , Caroline Uhler

Deep learning models have achieved strong performance in medical image analysis, but their internal decision processes remain difficult to interpret. Concept Bottleneck Models (CBMs) partially address this limitation by structuring…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Getamesay Dagnaw , Xuefei Yin , Muhammad Hassan Maqsood , Yanming Zhu , Alan Wee-Chung Liew

In recent years, deep learning models have revolutionized medical image interpretation, offering substantial improvements in diagnostic accuracy. However, these models often struggle with challenging images where critical features are…

Computer Vision and Pattern Recognition · Computer Science 2023-07-03 Pradeep Singh , Kishore Babu Nampalle , Uppala Vivek Narayan , Balasubramanian Raman

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

We present a deformable prototypical part network (Deformable ProtoPNet), an interpretable image classifier that integrates the power of deep learning and the interpretability of case-based reasoning. This model classifies input images by…

Computer Vision and Pattern Recognition · Computer Science 2024-05-06 Jon Donnelly , Alina Jade Barnett , Chaofan Chen

The potential of Multimodal Large Language Models (MLLMs) in domain of medical imaging raise the demands of systematic and rigorous evaluation frameworks that are aligned with the real-world medical imaging practice. Existing practices that…

Computation and Language · Computer Science 2026-04-16 Zhijie Bao , Fangke Chen , Licheng Bao , Chenhui Zhang , Wei Chen , Jiajie Peng , Zhongyu Wei

There has been considerable recent interest in interpretable concept-based models such as Concept Bottleneck Models (CBMs), which first predict human-interpretable concepts and then map them to output classes. To reduce reliance on…

Machine Learning · Computer Science 2024-07-08 Simon Schrodi , Julian Schur , Max Argus , Thomas Brox

Understanding the predictions made by deep learning models remains a central challenge, especially in high-stakes applications. A promising approach is to equip models with the ability to answer counterfactual questions -- hypothetical…

Machine Learning · Computer Science 2025-10-28 Inwoo Hwang , Yushu Pan , Elias Bareinboim

Explaining deep learning models is essential for clinical integration of medical image analysis systems. A good explanation highlights if a model depends on spurious features that undermines generalization and harms a subset of patients or,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-18 Yoni Schirris , Eric Marcus , Jonas Teuwen , Hugo Horlings , Efstratios Gavves

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

The increasing impact of black box models, and particularly of unsupervised ones, comes with an increasing interest in tools to understand and interpret them. In this paper, we consider in particular how to characterise visual groupings…

Computer Vision and Pattern Recognition · Computer Science 2020-10-29 Iro Laina , Ruth C. Fong , Andrea Vedaldi

Continual learning aims to update models under distribution shift without forgetting, yet many high-stakes deployments, such as healthcare, also require interpretability. In practice, models that adapt well (e.g., deep networks) are often…

Machine Learning · Computer Science 2026-04-21 Dongkyu Cho , Xiyue Li , Samrachana Adhikari , Rumi Chunara

Deep learning methods for classifying medical images have demonstrated impressive accuracy in a wide range of tasks but often these models are hard to interpret, limiting their applicability in clinical practice. In this work we introduce a…

Image and Video Processing · Electrical Eng. & Systems 2019-08-13 James R. Clough , Ilkay Oksuz , Esther Puyol-Anton , Bram Ruijsink , Andrew P. King , Julia A. Schnabel

Deep learning methods usually require a large amount of training data and lack interpretability. In this paper, we propose a novel knowledge distillation and model interpretation framework for medical image classification that jointly…

Computer Vision and Pattern Recognition · Computer Science 2022-01-13 Thanh Nguyen-Duc , He Zhao , Jianfei Cai , Dinh Phung