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Respondent-driven sampling (RDS) is a widely used method for sampling from hard-to-reach human populations, especially groups most at-risk for HIV/AIDS. Data are collected through a peer-referral process in which current sample members…

Methodology · Statistics 2012-09-28 Krista J. Gile , Lisa G. Johnston , Matthew J. Salganik

When individuals participating in a randomized trial differ with respect to the distribution of effect modifiers compared compared with the target population where the trial results will be used, treatment effect estimates from the trial…

Difference-in-differences (DID) is popular because it can allow for unmeasured confounding when the key assumption of parallel trends holds. However, there exists little guidance on how to decide a priori whether this assumption is…

Methodology · Statistics 2025-05-07 Audrey Renson , Oliver Dukes , Zach Shahn

Objective: Randomized controlled trial (RCT) results often inform clinical decision-making, but the highly curated populations of trials and the care provided during the trial are often not reflective of real-world practice. The objective…

Applications · Statistics 2024-02-26 Guanbo Wang , Ting-Wei Ernie Liao , David Furfaro , Leo Anthony Celi , Kevin Sheng-Kai Ma

Data-driven methods for personalizing treatment assignment have garnered much attention from clinicians and researchers. Dynamic treatment regimes formalize this through a sequence of decision rules that map individual patient…

Methodology · Statistics 2022-02-22 Eric J. Rose , Erica E. M. Moodie , Susan Shortreed

Nearly all statistical analyses that inform policy-making are based on imperfect data. As examples, the data may suffer from measurement errors, missing values, sample selection bias, or record linkage errors. Analysts have to decide how to…

Methodology · Statistics 2025-10-24 Adway S. Wadekar , Jerome P. Reiter

We introduce the causal responders detection (CARD), a novel method for responder analysis that identifies treated subjects who significantly respond to a treatment. Leveraging recent advances in conformal prediction, CARD employs machine…

Methodology · Statistics 2024-06-26 Tzviel Frostig , Oshri Machluf , Amitay Kamber , Elad Berkman , Raviv Pryluk

Analyzing and effectively communicating the efficacy and toxicity of treatment is the basis of risk benefit analysis (RBA). More efficient and objective tools are needed. We apply Chauhan Weighted Trajectory Analysis (CWTA) to perform RBA…

Methodology · Statistics 2024-09-24 Utkarsh Chauhan , Daylen Mackey , John R Mackey

This research paper outlines the development and implementation of a novel Clinical Decision Support System (CDSS) that integrates AI predictive modeling with medical knowledge bases. It utilizes the quantifiable information elements in lab…

Artificial Intelligence · Computer Science 2026-03-17 Muhammad Hammad Maqsood , Mubashir Sajid , Khubaib Ahmed , Muhammad Usamah Shahid , Muddassar Farooq

Existing work in data fusion has covered identification of causal estimands when integrating data from heterogeneous sources. These results typically require additional assumptions to make valid estimation and inference. However, there is…

Methodology · Statistics 2023-01-10 Ngoc Q. Duong , Amy J. Pitts , Soohyun Kim , Caleb H. Miles

Current clinical decision support systems (DSS) are trained and validated on observational data from the target clinic. This is problematic for treatments validated in a randomized clinical trial (RCT), but not yet introduced in any clinic.…

Randomized controlled trials are the gold standard for causal inference and play a pivotal role in modern evidence-based medicine. However, the sample sizes they use are often too limited to draw significant causal conclusions for subgroups…

Methodology · Statistics 2024-04-26 Xi Lin , Jens Magelund Tarp , Robin J. Evans

Global sensitivity analysis (GSA) aims to detect influential input factors that lead a model to arrive at a certain decision and is a significant approach for mitigating the computational burden of processing high dimensional data. In this…

Machine Learning · Computer Science 2024-06-26 Zahra Sadeghi , Stan Matwin

Real world observational data, together with causal inference, allow the estimation of causal effects when randomized controlled trials are not available. To be accepted into practice, such predictive models must be validated for the…

Root cause analysis is one of the most crucial operations in software reliability regarding system performance diagnostic. It aims to identify the root causes of system performance anomalies, allowing the resolution or the future prevention…

Software Engineering · Computer Science 2025-01-22 Andrea Tonon , Meng Zhang , Bora Caglayan , Fei Shen , Tong Gui , MingXue Wang , Rong Zhou

Large Language Models (LLMs) and their multimodal variants (LVLMs) hold immense promise for scientific and engineering applications, particularly in processing visual information like scientific diagrams. However, their practical deployment…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Minghao Zhou , Rafael Souza , Yaqian Hu , Luming Che

Exploring causal relationships in stochastic time series is a challenging yet crucial task with a vast range of applications, including finance, economics, neuroscience, and climate science. Many algorithms for Causal Discovery (CD) have…

Machine Learning · Computer Science 2026-02-19 Matteo Tusoni , Giuseppe Masi , Andrea Coletta , Aldo Glielmo , Viviana Arrigoni , Novella Bartolini

Cognitive Diagnosis~(CD), which leverages students and exercise data to predict students' proficiency levels on different knowledge concepts, is one of fundamental components in Intelligent Education. Due to the scarcity of student-exercise…

Machine Learning · Computer Science 2024-06-06 Dacao Zhang , Kun Zhang , Le Wu , Mi Tian , Richang Hong , Meng Wang

As machine learning models become increasingly prevalent in motion forecasting for autonomous vehicles (AVs), it is critical to ensure that model predictions are safe and reliable. However, exhaustively collecting and labeling the data…

Machine Learning · Computer Science 2022-10-10 Rebecca Roelofs , Liting Sun , Ben Caine , Khaled S. Refaat , Ben Sapp , Scott Ettinger , Wei Chai

Recent approaches to empathetic response generation incorporate emotion causalities to enhance comprehension of both the user's feelings and experiences. However, these approaches suffer from two critical issues. First, they only consider…

Computation and Language · Computer Science 2024-04-09 Jiashuo Wang , Yi Cheng , Wenjie Li
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