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Model trees provide an appealing way to perform interpretable machine learning for both classification and regression problems. In contrast to ``classic'' decision trees with constant values in their leaves, model trees can use linear…

Machine Learning · Computer Science 2026-03-11 Sabino Francesco Roselli , Eibe Frank

Building generalizable AI models is one of the primary challenges in the healthcare domain. While radiologists rely on generalizable descriptive rules of abnormality, Neural Network (NN) models suffer even with a slight shift in input…

Computer Vision and Pattern Recognition · Computer Science 2023-07-12 Shantanu Ghosh , Ke Yu , Kayhan Batmanghelich

Deep models have advanced prediction in many domains, but their lack of interpretability remains a key barrier to the adoption in many real world applications. There exists a large body of work aiming to help humans understand these black…

Machine Learning · Computer Science 2019-08-15 Mike Wu , Sonali Parbhoo , Michael C. Hughes , Volker Roth , Finale Doshi-Velez

Machine learning models, particularly the black-box models, are widely favored for their outstanding predictive capabilities. However, they often face scrutiny and criticism due to the lack of interpretability. Paradoxically, their strong…

Methodology · Statistics 2025-09-17 Xuetao Lu , J. Jack Lee

Machine learning models are often criticized for their black-box nature, raising concerns about their applicability in critical decision-making scenarios. Consequently, there is a growing demand for interpretable models in such contexts. In…

Machine Learning · Computer Science 2024-08-28 I-Ling Cheng , Chan Hsu , Chantung Ku , Pei-Ju Lee , Yihuang Kang

Supervised Machine Learning (SML) algorithms such as Gradient Boosting, Random Forest, and Neural Networks have become popular in recent years due to their increased predictive performance over traditional statistical methods. This is…

Machine Learning · Statistics 2018-06-05 Linwei Hu , Jie Chen , Vijayan N. Nair , Agus Sudjianto

We present an interpretable companion model for any pre-trained black-box classifiers. The idea is that for any input, a user can decide to either receive a prediction from the black-box model, with high accuracy but no explanations, or…

Machine Learning · Statistics 2020-02-12 Danqing Pan , Tong Wang , Satoshi Hara

Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep…

Machine Learning · Statistics 2015-12-14 Zhengping Che , Sanjay Purushotham , Robinder Khemani , Yan Liu

Tree-based machine learning models such as random forests, decision trees, and gradient boosted trees are the most popular non-linear predictive models used in practice today, yet comparatively little attention has been paid to explaining…

Machine learning methods for estimating treatment effect heterogeneity promise greater flexibility than existing methods that test a few pre-specified hypotheses. However, one problem these methods can have is that it can be challenging to…

Econometrics · Economics 2024-08-05 Patrick Rehill

The lack of interpretability remains a barrier to the adoption of deep neural networks. Recently, tree regularization has been proposed to encourage deep neural networks to resemble compact, axis-aligned decision trees without significant…

Machine Learning · Computer Science 2020-03-17 Mike Wu , Sonali Parbhoo , Michael Hughes , Ryan Kindle , Leo Celi , Maurizio Zazzi , Volker Roth , Finale Doshi-Velez

Data-driven models are central to scientific discovery. In efforts to achieve state-of-the-art model accuracy, researchers are employing increasingly complex machine learning algorithms that often outperform simple regressions in…

Materials Science · Physics 2022-12-21 Eric S. Muckley , James E. Saal , Bryce Meredig , Christopher S. Roper , John H. Martin

Understanding the differences between machine learning (ML) models is of interest in scenarios ranging from choosing amongst a set of competing models, to updating a deployed model with new training data. In these cases, we wish to go…

Machine Learning · Computer Science 2023-06-14 Swagatam Haldar , Diptikalyan Saha , Dennis Wei , Rahul Nair , Elizabeth M. Daly

One approach for interpreting black-box machine learning models is to find a global approximation of the model using simple interpretable functions, which is called a metamodel (a model of the model). Approximating the black-box with a…

Machine Learning · Computer Science 2023-02-10 Mahed Abroshan , Saumitra Mishra , Mohammad Mahdi Khalili

Tree ensemble models like random forests and gradient boosting machines are widely used in machine learning due to their excellent predictive performance. However, a high-performance ensemble consisting of a large number of decision trees…

Machine Learning · Statistics 2024-10-28 Zebin Yang , Agus Sudjianto , Xiaoming Li , Aijun Zhang

In order to develop reliable services using machine learning, it is important to understand the uncertainty of the model outputs. Often the probability distribution that the prediction target follows has a complex shape, and a mixture…

Machine Learning · Computer Science 2021-05-11 Ryuichi Kanoh , Tomu Yanabe

Many problems in computer vision have recently been tackled using models whose predictions cannot be easily interpreted, most commonly deep neural networks. Surrogate explainers are a popular post-hoc interpretability method to further…

Computer Vision and Pattern Recognition · Computer Science 2022-10-11 Ricardo Kleinlein , Alexander Hepburn , Raúl Santos-Rodríguez , Fernando Fernández-Martínez

How can we find interpretable, domain-appropriate models of natural phenomena given some complex, raw data such as images? Can we use such models to derive scientific insight from the data? In this paper, we propose some methods for…

Machine Learning · Computer Science 2024-02-06 Christopher J. Soelistyo , Alan R. Lowe

Despite outstanding contribution to the significant progress of Artificial Intelligence (AI), deep learning models remain mostly black boxes, which are extremely weak in explainability of the reasoning process and prediction results.…

Machine Learning · Computer Science 2020-02-11 Sheng Shi , Xinfeng Zhang , Wei Fan

As a multitude of capable machine learning (ML) models become widely available in forms such as open-source software and public APIs, central questions remain regarding their use in real-world applications, especially in high-stakes…

Machine Learning · Computer Science 2024-06-03 Dimitris Bertsimas , Matthew Peroni