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As machine learning systems become ubiquitous, there has been a surge of interest in interpretable machine learning: systems that provide explanation for their outputs. These explanations are often used to qualitatively assess other…

Machine Learning · Statistics 2017-03-06 Finale Doshi-Velez , Been Kim

Improving the interpretability of brain decoding approaches is of primary interest in many neuroimaging studies. Despite extensive studies of this type, at present, there is no formal definition for interpretability of brain decoding…

Machine Learning · Statistics 2016-06-21 Seyed Mostafa Kia , Andrea Passerini

In this review, we examine the problem of designing interpretable and explainable machine learning models. Interpretability and explainability lie at the core of many machine learning and statistical applications in medicine, economics,…

Machine Learning · Computer Science 2023-03-02 Ričards Marcinkevičs , Julia E. Vogt

We provide a novel notion of what it means to be interpretable, looking past the usual association with human understanding. Our key insight is that interpretability is not an absolute concept and so we define it relative to a target model,…

Artificial Intelligence · Computer Science 2017-07-14 Amit Dhurandhar , Vijay Iyengar , Ronny Luss , Karthikeyan Shanmugam

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

Interpretable Machine Learning (IML) has become increasingly important in many real-world applications, such as autonomous cars and medical diagnosis, where explanations are significantly preferred to help people better understand how…

Machine Learning · Computer Science 2019-08-19 Fan Yang , Mengnan Du , Xia Hu

While the uptake of data-driven approaches for materials science and chemistry is at an exciting, early stage, to realise the true potential of machine learning models for successful scientific discovery, they must have qualities beyond…

Materials Science · Physics 2022-06-28 Felipe Oviedo , Juan Lavista Ferres , Tonio Buonassisi , Keith Butler

This paper explores the significant impact of AI-based medical devices, including wearables, telemedicine, large language models, and digital twins, on clinical decision support systems. It emphasizes the importance of producing outcomes…

Artificial Intelligence · Computer Science 2024-04-11 Elham Nasarian , Roohallah Alizadehsani , U. Rajendra Acharya , Kwok-Leung Tsui

The increasing adoption of machine learning tools has led to calls for accountability via model interpretability. But what does it mean for a machine learning model to be interpretable by humans, and how can this be assessed? We focus on…

Machine Learning · Computer Science 2019-08-06 Dylan Slack , Sorelle A. Friedler , Carlos Scheidegger , Chitradeep Dutta Roy

Artificial Intelligence has emerged as a useful aid in numerous clinical applications for diagnosis and treatment decisions. Deep neural networks have shown same or better performance than clinicians in many tasks owing to the rapid…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Zohaib Salahuddin , Henry C Woodruff , Avishek Chatterjee , Philippe Lambin

Machine-learning models have demonstrated great success in learning complex patterns that enable them to make predictions about unobserved data. In addition to using models for prediction, the ability to interpret what a model has learned…

Machine Learning · Statistics 2019-11-15 W. James Murdoch , Chandan Singh , Karl Kumbier , Reza Abbasi-Asl , Bin Yu

Through extensive experience developing and explaining machine learning (ML) applications for real-world domains, we have learned that ML models are only as interpretable as their features. Even simple, highly interpretable model types such…

Machine Learning · Computer Science 2022-02-25 Alexandra Zytek , Ignacio Arnaldo , Dongyu Liu , Laure Berti-Equille , Kalyan Veeramachaneni

Though neural networks trained on large datasets have been successfully used to describe and predict many physical phenomena, there is a sense among scientists that, unlike traditional scientific models comprising simple mathematical…

Machine Learning · Computer Science 2026-04-23 Conor Rowan , Alireza Doostan

Interpretability aims to explain the behavior of deep neural networks. Despite rapid growth, there is mounting concern that much of this work has not translated into practical impact, raising questions about its relevance and utility. This…

High-throughput technologies such as next generation sequencing allow biologists to observe cell function with unprecedented resolution, but the resulting datasets are too large and complicated for humans to understand without the aid of…

Applications · Statistics 2021-10-08 David S. Watson

Interpretable machine learning has exploded as an area of interest over the last decade, sparked by the rise of increasingly large datasets and deep neural networks. Simultaneously, large language models (LLMs) have demonstrated remarkable…

Computation and Language · Computer Science 2024-02-06 Chandan Singh , Jeevana Priya Inala , Michel Galley , Rich Caruana , Jianfeng Gao

Supervised machine learning models boast remarkable predictive capabilities. But can you trust your model? Will it work in deployment? What else can it tell you about the world? We want models to be not only good, but interpretable. And yet…

Machine Learning · Computer Science 2017-03-07 Zachary C. Lipton

Being able to interpret, or explain, the predictions made by a machine learning model is of fundamental importance. This is especially true when there is interest in deploying data-driven models to make high-stakes decisions, e.g. in…

Machine Learning · Computer Science 2019-10-01 An-phi Nguyen , María Rodríguez Martínez

Large language models (LLMs) have achieved remarkable capabilities across diverse tasks, yet their internal decision-making processes remain largely opaque. Mechanistic interpretability (i.e., the systematic study of how neural networks…

Computation and Language · Computer Science 2026-02-13 Usman Naseem

With machine learning models being increasingly used to aid decision making even in high-stakes domains, there has been a growing interest in developing interpretable models. Although many supposedly interpretable models have been proposed,…

Artificial Intelligence · Computer Science 2021-08-17 Forough Poursabzi-Sangdeh , Daniel G. Goldstein , Jake M. Hofman , Jennifer Wortman Vaughan , Hanna Wallach