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This paper is concerned with the approximation of probability distributions known up to normalization constants, with a focus on Bayesian inference for large-scale inverse problems in scientific computing. In this context, key challenges…

Machine Learning · Computer Science 2025-06-10 Baojun Che , Yifan Chen , Zhenghao Huan , Daniel Zhengyu Huang , Weijie Wang

We provide the first convergence guarantee for full black-box variational inference (BBVI), also known as Monte Carlo variational inference. While preliminary investigations worked on simplified versions of BBVI (e.g., bounded domain,…

Machine Learning · Computer Science 2024-01-12 Kyurae Kim , Jisu Oh , Kaiwen Wu , Yi-An Ma , Jacob R. Gardner

The metric space of phylogenetic trees defined by Billera, Holmes, and Vogtmann, which we refer to as BHV space, provides a natural geometric setting for describing collections of trees on the same set of taxa. However, it is sometimes…

Populations and Evolution · Quantitative Biology 2018-07-12 Gillian Grindstaff , Megan Owen

Continuous latent time series models are prevalent in Bayesian modeling; examples include the Kalman filter, dynamic collaborative filtering, or dynamic topic models. These models often benefit from structured, non mean field variational…

Machine Learning · Statistics 2017-07-05 Robert Bamler , Stephan Mandt

Variational inference is computationally challenging in models that contain both conjugate and non-conjugate terms. Methods specifically designed for conjugate models, even though computationally efficient, find it difficult to deal with…

Machine Learning · Computer Science 2017-04-14 Mohammad Emtiyaz Khan , Wu Lin

Background: Continuous traits evolution of a group of taxa that are correlated through a phylogenetic tree is commonly modelled using parametric stochastic differential equations to represent deterministic change of trait through time,…

Populations and Evolution · Quantitative Biology 2026-04-03 Bayu Brahmantio , Krzysztof Bartoszek , Etka Yapar

Semi-implicit variational inference (SIVI) enriches the expressiveness of variational families by utilizing a kernel and a mixing distribution to hierarchically define the variational distribution. Existing SIVI methods parameterize the…

Machine Learning · Statistics 2025-01-16 Jen Ning Lim , Adam M. Johansen

Deep Gaussian processes (DGPs) enable expressive hierarchical Bayesian modeling but pose substantial challenges for posterior inference, especially over inducing variables. Denoising diffusion variational inference (DDVI) addresses this by…

Machine Learning · Computer Science 2026-02-13 Jian Xu , Qibin Zhao , John Paisley , Delu Zeng

Ultrametric matrices are a class of covariance matrices that arise in latent tree models. As a parameter space in a statistical model, the set of ultrametric matrices is neither convex nor a smooth manifold. Focus in the literature has…

Methodology · Statistics 2025-04-28 Tsung-Hung Yao , Zhenke Wu , Karthik Bharath , Veerabhadran Baladandayuthapani

The recursive and hierarchical structure of full rooted trees is applicable to represent statistical models in various areas, such as data compression, image processing, and machine learning. In most of these cases, the full rooted tree is…

Machine Learning · Statistics 2022-03-24 Yuta Nakahara , Shota Saito , Akira Kamatsuka , Toshiyasu Matsushima

Approximate inference in Bayesian deep networks exhibits a dilemma of how to yield high fidelity posterior approximations while maintaining computational efficiency and scalability. We tackle this challenge by introducing a novel…

Machine Learning · Computer Science 2021-11-01 Son Nguyen , Duong Nguyen , Khai Nguyen , Khoat Than , Hung Bui , Nhat Ho

Motivation: Modern biobanks, with unprecedented sample sizes and phenotypic diversity, have become foundational resources for genomic studies, enabling powerful cross-phenotype and population-scale analyses. As studies grow in complexity,…

Applications · Statistics 2026-04-30 Yiran Li , John Whittaker , Sylvia Richardson , Helene Ruffieux

We propose a method to approximate the distribution of robot configurations satisfying multiple objectives. Our approach uses variational inference, a popular method in Bayesian computation, which has several advantages over sampling-based…

Robotics · Computer Science 2019-11-25 Emmanuel Pignat , Teguh Lembono , Sylvain Calinon

Density estimation is essential for generative modeling, particularly with the rise of modern neural networks. While existing methods capture complex data distributions, they often lack interpretability and uncertainty quantification.…

Machine Learning · Computer Science 2025-10-28 Lu Xu , Tsai Hor Chan , Kwok Fai Lam , Lequan Yu , Guosheng Yin

Scientific studies in many areas of biology routinely employ evolutionary analyses based on the probabilistic inference of phylogenetic trees from molecular sequence data. Evolutionary processes that act at the molecular level are highly…

Populations and Evolution · Quantitative Biology 2024-12-10 Mandev S. Gill , Guy Baele , Marc A. Suchard , Philippe Lemey

Variable-length Markov chains (VLMCs) are a flexible class of higher-order Markov models that admit a natural representation as context trees. Existing Bayesian methods for specifying prior distributions on tree structures rely on branching…

Methodology · Statistics 2026-05-11 Thiago Paulichen , Victor Freguglia

Variational Bayes (VB), also known as independent mean-field approximation, has become a popular method for Bayesian network inference in recent years. Its application is vast, e.g. in neural network, compressed sensing, clustering, etc. to…

Information Theory · Computer Science 2018-03-30 Viet Hung Tran

We propose denoising diffusion variational inference (DDVI), a black-box variational inference algorithm for latent variable models which relies on diffusion models as flexible approximate posteriors. Specifically, our method introduces an…

Machine Learning · Computer Science 2026-03-16 Wasu Top Piriyakulkij , Yingheng Wang , Volodymyr Kuleshov

A method was developed for Bayesian inference of species phylogeny using the multi-species coalescent model. To improve the mixing properties of the Markov chain Monte Carlo (MCMC) algorithm that traverses the space of species trees, we…

Populations and Evolution · Quantitative Biology 2015-12-15 Bruce Rannala , Ziheng Yang

Black-box variational inference (BBVI) now sees widespread use in machine learning and statistics as a fast yet flexible alternative to Markov chain Monte Carlo methods for approximate Bayesian inference. However, stochastic optimization…

Machine Learning · Statistics 2025-09-22 Manushi Welandawe , Michael Riis Andersen , Aki Vehtari , Jonathan H. Huggins