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The structure and function of biological molecules are strongly influenced by the water and dissolved ions that surround them. This aqueous solution (solvent) exerts significant electrostatic forces in response to the biomolecule's…

Numerical Analysis · Mathematics 2015-12-29 Matthew G. Knepley , Jaydeep P. Bardhan

The Immersed Boundary method is a simple, efficient, and robust numerical scheme for solving PDE in general domains, yet for fluid problems it only achieves first-order spatial accuracy near embedded boundaries for the velocity field and…

Numerical Analysis · Mathematics 2017-03-08 David B. Stein , Robert D. Guy , Becca Thomases

For scattering problems of time-harmonic waves, the boundary integral equation (BIE) methods are highly competitive, since they are formulated on lower-dimension boundaries or interfaces, and can automatically satisfy outgoing radiation…

Numerical Analysis · Mathematics 2018-04-24 Wangtao Lu , Ya Yan Lu , Jianliang Qian

The velocity and trajectory of particle moving along the corrugated (rough) surface under action of gravity is obtained by meshless Boundary Singularity Method (BSM). This physical situation is found often in biological systems and…

Fluid Dynamics · Physics 2025-09-09 Alex Povitsky

The immersed boundary (IB) method has been used as a means to simulate fluid-membrane interactions in a wide variety of biological and engineering applications. Although the numerical convergence of the method has been empirically verified,…

Numerical Analysis · Mathematics 2025-10-09 Alexandre X. Milewski , Charles S. Peskin

Fluid flows containing dilute or dense suspensions of thin fibers are widespread in biological and industrial processes. To describe the motion of a thin immersed fiber, or to describe the forces acting on it, it is convenient to work with…

Numerical Analysis · Mathematics 2021-12-03 William H. Mitchell , Henry G. Bell , Yoichiro Mori , Laurel Ohm , Daniel Spirn

The manuscript describes a quadrature rule that is designed for the high order discretization of boundary integral equations (BIEs) using the Nystr\"{o}m method. The technique is designed for surfaces that can naturally be parameterized…

Numerical Analysis · Mathematics 2020-07-07 Bowei Wu , Per-Gunnar Martinsson

We present a novel platform for the large-scale simulation of fibrous structures immersed in a Stokesian fluid and evolving under confinement or in free-space. One of the main motivations for this work is to study the dynamics of fiber…

Numerical Analysis · Mathematics 2017-01-04 Ehssan Nazockdast , Abtin Rahimian , Denis Zorin , Michael Shelley

Semiflexible slender filaments are ubiquitous in nature and cell biology, including in the cytoskeleton, where reorganization of actin filaments allows the cell to move and divide. Most methods for simulating semiflexible inextensible…

Numerical Analysis · Mathematics 2023-05-03 Ondrej Maxian , Brennan Sprinkle , Aleksandar Donev

We present a fluctuating boundary integral method (FBIM) for overdamped Brownian Dynamics (BD) of two-dimensional periodic suspensions of rigid particles of complex shape immersed in a Stokes fluid. We develop a novel approach for…

Numerical Analysis · Mathematics 2018-09-26 Yuanxun Bao , Manas Rachh , Eric Keaveny , Leslie Greengard , Aleksandar Donev

We introduce a novel quadrature strategy for Isogeometric Analysis (IgA) boundary element discretizations, specifically tailored to collocation methods. Thanks to the dimensionality reduction and the natural handling of unbounded domains,…

Numerical Analysis · Mathematics 2025-11-25 Cesare Bracco , Francesco Patrizi , Alessandra Sestini

The eigenvalues and eigenfunctions of the Stokes operator have been the subject of intense analytical investigation and have applications in the study and simulation of the Navier-Stokes equations. As the Stokes operator is a fourth-order…

Numerical Analysis · Mathematics 2019-04-17 Travis Askham , Manas Rachh

A second-order accurate kernel-free boundary integral method is presented for Stokes and Navier boundary value problems on three-dimensional irregular domains. It solves equations in the framework of boundary integral equations, whose…

Numerical Analysis · Mathematics 2023-06-28 Zhongshu Zhao , Haixia Dong , Wenjun Ying

A fourth-order finite volume embedded boundary (EB) method is presented for the unsteady Stokes equations. The algorithm represents complex geometries on a Cartesian grid using EB, employing a technique to mitigate the "small cut-cell"…

Numerical Analysis · Mathematics 2022-09-08 Nathaniel Overton-Katz , Xinfeng Gao , Stephen Guzik , Oscar Antepara , Daniel T. Graves , Hans Johansen

In this work we consider how surface-adherent bacterial biofilm communities respond in flowing systems. We simulate the fluid-structure interaction and separation process using the immersed boundary method. In these simulations we model and…

Numerical Analysis · Mathematics 2013-02-18 Jason F. Hammond , Elizabeth J. Stewart , John G. Younger , Michael J. Solomon , David M. Bortz

We show that the standard boundary integral operators, defined on the unit sphere, for the Stokes equations diagonalize on a specific set of vector spherical harmonics and provide formulas for their spectra. We also derive analytical…

Numerical Analysis · Mathematics 2018-04-04 Eduardo Corona , Shravan Veerapaneni

Slender fibers are ubiquitous in biology, physics, and engineering, with prominent examples including bacterial flagella and cytoskeletal fibers. In this setting, slender body theories (SBTs), which give the resistance on the fiber…

Fluid Dynamics · Physics 2022-11-30 Ondrej Maxian , Aleksandar Donev

This paper introduces a new immersed boundary (IB) method for viscous incompressible flow, based on a Fourier spectral method for the fluid solver and on the nonuniform fast Fourier transform (NUFFT) algorithm for coupling the fluid with…

Fluid Dynamics · Physics 2023-02-20 Zhe Chen , Charles S. Peskin

In this paper, we first develop a mathematical model for long-range, hydrophobic attraction between amphiphilic particles. The non-pairwise interactions follow from the first variation of a hydrophobic attraction domain functional. The…

Numerical Analysis · Mathematics 2019-07-19 Szu-Pei P. Fu , Rolf J. Ryham , Andreas Klöckner , Matt Wala , Shidong Jiang , Yuan-Nan Young

The method of regularized stokeslets is a powerful numerical method to solve the Stokes flow equations for problems in biological fluid mechanics. A recent variation of this method incorporates a nearest-neighbor discretization to improve…

Fluid Dynamics · Physics 2018-06-06 Meurig T. Gallagher , Debajyoti Choudhuri , David J. Smith