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Continuous Conditional Diffusion Model (CCDM) is a diffusion-based framework designed to generate high-quality images conditioned on continuous regression labels. Although CCDM has demonstrated clear advantages over prior approaches across…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Xin Ding , Yun Chen , Sen Zhang , Kao Zhang , Nenglun Chen , Peibei Cao , Yongwei Wang , Fei Wu

Symbolic regression refers to the task of finding a closed-form mathematical expression to fit a set of data points. Genetic programming based techniques are the most common algorithms used to tackle this problem, but recently,…

Machine Learning · Computer Science 2025-10-10 Ryan T. Tymkow , Benjamin D. Schnapp , Mojtaba Valipour , Ali Ghodshi

While generative models have seen significant adoption across a wide range of data modalities, including 3D data, a consensus on which model is best suited for which task has yet to be reached. Further, conditional information such as text…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Matthias Humt , Ulrich Hillenbrand , Rudolph Triebel

The discovery of inorganic crystal structures with targeted properties is a significant challenge in materials science. Generative models, especially state-of-the-art diffusion models, offer the promise of modeling complex data…

Understanding and representing the structure of 3D objects in an unsupervised manner remains a core challenge in computer vision and graphics. Most existing unsupervised keypoint methods are not designed for unconditional generative…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Rhys Newbury , Juyan Zhang , Tin Tran , Hanna Kurniawati , Dana Kulić

Recent Diffusion Transformers (e.g., DiT) have demonstrated their powerful effectiveness in generating high-quality 2D images. However, it is still being determined whether the Transformer architecture performs equally well in 3D shape…

Computer Vision and Pattern Recognition · Computer Science 2023-07-06 Shentong Mo , Enze Xie , Ruihang Chu , Lewei Yao , Lanqing Hong , Matthias Nießner , Zhenguo Li

Designing 3D ligands within a target binding site is a fundamental task in drug discovery. Existing structured-based drug design methods treat all ligand atoms equally, which ignores different roles of atoms in the ligand for drug design…

Biomolecules · Quantitative Biology 2024-03-14 Jiaqi Guan , Xiangxin Zhou , Yuwei Yang , Yu Bao , Jian Peng , Jianzhu Ma , Qiang Liu , Liang Wang , Quanquan Gu

While many unsupervised learning models focus on one family of tasks, either generative or discriminative, we explore the possibility of a unified representation learner: a model which uses a single pre-training stage to address both…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Soumik Mukhopadhyay , Matthew Gwilliam , Vatsal Agarwal , Namitha Padmanabhan , Archana Swaminathan , Srinidhi Hegde , Tianyi Zhou , Abhinav Shrivastava

Diffusion models are important in tissue engineering as they enable an understanding of molecular delivery to cells in tissue constructs. As three-dimensional (3D) tissue constructs become larger, more intricate, and more clinically…

Tissues and Organs · Quantitative Biology 2015-12-22 Richard J. McMurtrey

Denoising diffusion models represent a recent emerging topic in computer vision, demonstrating remarkable results in the area of generative modeling. A diffusion model is a deep generative model that is based on two stages, a forward…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Florinel-Alin Croitoru , Vlad Hondru , Radu Tudor Ionescu , Mubarak Shah

Accurate trajectory prediction is crucial for the safe and efficient operation of autonomous vehicles. The growing popularity of deep learning has led to the development of numerous methods for trajectory prediction. While deterministic…

Machine Learning · Computer Science 2023-08-30 Kehua Chen , Xianda Chen , Zihan Yu , Meixin Zhu , Hai Yang

Diffusion models have established themselves as the de facto primary paradigm in visual generative modeling, revolutionizing the field through remarkable success across various diverse applications ranging from high-quality image synthesis…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Zhiyu Tan , WenXu Qian , Hesen Chen , Mengping Yang , Lei Chen , Hao Li

Recent advances in generative models, particularly diffusion and auto-regressive models, have revolutionized fields like computer vision and natural language processing. However, their application to structure-based drug design (SBDD)…

Machine Learning · Computer Science 2025-07-29 Yi He , Ailun Wang , Zhi Wang , Yu Liu , Xingyuan Xu , Wen Yan

Diffusion models have garnered significant attention since they can effectively learn complex multivariate Gaussian distributions, resulting in diverse, high-quality outcomes. They introduce Gaussian noise into training data and reconstruct…

Computer Vision and Pattern Recognition · Computer Science 2023-12-27 Vidya Prasad , Chen Zhu-Tian , Anna Vilanova , Hanspeter Pfister , Nicola Pezzotti , Hendrik Strobelt

The proliferation of deep learning accelerators calls for efficient and cost-effective hardware design solutions, where parameterized modular hardware generator and electronic design automation (EDA) tools play crucial roles in improving…

Hardware Architecture · Computer Science 2025-04-01 Yi Ren , Chenhao Xue , Jiaxing Zhang , Chen Zhang , Qiang Xu , Yibo Lin , Lining Zhang , Guangyu Sun

Diffusion models have shown great promise for image generation, beating GANs in terms of generation diversity, with comparable image quality. However, their application to 3D shapes has been limited to point or voxel representations that…

Computer Vision and Pattern Recognition · Computer Science 2022-12-16 Gimin Nam , Mariem Khlifi , Andrew Rodriguez , Alberto Tono , Linqi Zhou , Paul Guerrero

Generative models for 3D molecular conformations must respect Euclidean symmetries and concentrate probability mass on thermodynamically favorable, mechanically stable structures. However, E(3)-equivariant diffusion models often reproduce…

Machine Learning · Computer Science 2026-01-30 Yunyang Li , Lin Huang , Luojia Xia , Wenhe Zhang , Mark Gerstein

Generative models have become significant assets in the exploration and identification of new materials, enabling the rapid proposal of candidate crystal structures that satisfy target properties. Despite the increasing adoption of diverse…

Machine Learning · Computer Science 2025-10-21 Charles Rhys Campbell , Aldo H. Romero , Kamal Choudhary

Diffusion models are highly regarded for their controllability and the diversity of images they generate. However, class-conditional generation methods based on diffusion models often focus on more common categories. In large-scale…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Kun Wang , Donglin Di , Tonghua Su , Lei Fan

Combining discrete and continuous data is an important capability for generative models. We present Discrete Flow Models (DFMs), a new flow-based model of discrete data that provides the missing link in enabling flow-based generative models…

Machine Learning · Statistics 2024-06-07 Andrew Campbell , Jason Yim , Regina Barzilay , Tom Rainforth , Tommi Jaakkola
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