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Raman spectroscopy enables non-destructive, label-free molecular analysis with high specificity, making it a powerful tool for biomedical diagnostics. However, its application to biological tissues is challenged by inherently weak Raman…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Mengkun Chen , Sanidhya D. Tripathi , James W. Tunnell

Raman spectra obtained in real world applications are often a noisy combination of several spectra of various substances in a tested sample. Unmixing such spectra into individual components corresponding to each of the substances is of…

Machine Learning · Computer Science 2026-04-27 Gaoruishu Long , Jinchao Liu , Bo Liu , Jie Liu , Xiaolin Hu

Raman spectroscopy can provide insight into the molecular composition of cells and tissue. Consequently, it can be used as a powerful diagnostic tool, e.g. to help identify changes in molecular contents with the onset of disease. But robust…

Medical Physics · Physics 2023-08-02 Ciaran Bench , Mads S. Bergholt , Mohamed Ali al-Badri

While deep learning offers powerful capabilities for scientific research, its application is often hindered by a lack of quantitative reliability. To address this, we introduce a probabilistic denoising framework that simultaneously…

Strongly Correlated Electrons · Physics 2026-05-11 Younsik Kim , Changyoung Kim

De-noising plays a crucial role in the post-processing of spectra. Machine learning-based methods show good performance in extracting intrinsic information from noisy data, but often require a high-quality training set that is typically…

Materials Science · Physics 2023-05-16 Dongchen Huang , Junde Liu , Tian Qian , Yi-feng Yang

Spectroscopy represents the ideal observational method to maximally extract information from galaxies regarding their star formation and chemical enrichment histories. However, absorption spectra of galaxies prove rather challenging at high…

Instrumentation and Methods for Astrophysics · Physics 2025-10-10 Oliver Camilleri , Zahra Sharbaf , Ignacio Ferreras

In spectroscopic experiments, data acquisition in multi-dimensional phase space may require long acquisition time, owing to the large phase space volume to be covered. In such case, the limited time available for data acquisition can be a…

Micro-Doppler analysis has become increasingly popular in recent years owning to the ability of the technique to enhance classification strategies. Applications include recognising everyday human activities, distinguishing drone from birds,…

Signal Processing · Electrical Eng. & Systems 2021-02-16 Chong Tang , Wenda Li , Shelly Vishwakarma , Karl Woodbridge , Simon Julier , Kevin Chetty

Supervised learning-based methods yield robust denoising results, yet they are inherently limited by the need for large-scale clean/noisy paired datasets. The use of unsupervised denoisers, on the other hand, necessitates a more detailed…

Image and Video Processing · Electrical Eng. & Systems 2021-11-30 Nahyun Kim , Donggon Jang , Sunhyeok Lee , Bomi Kim , Dae-Shik Kim

Deep neural network based methods are the state of the art in various image restoration problems. Standard supervised learning frameworks require a set of noisy measurement and clean image pairs for which a distance between the output of…

Image and Video Processing · Electrical Eng. & Systems 2021-03-31 Rihuan Ke , Carola-Bibiane Schönlieb

In a normal indoor environment, Raman spectrum encounters noise often conceal spectrum peak, leading to difficulty in spectrum interpretation. This paper proposes deep learning (DL) based noise reduction technique for Raman spectroscopy.…

Signal Processing · Electrical Eng. & Systems 2020-09-10 Liangrui Pan , Pronthep Pipitsunthonsan , Peng Zhang , Chalongrat Daengngam , Apidach Booranawong , Mitcham Chongcheawchamnan

Hyperspectral imaging has been widely used for spectral and spatial identification of target molecules, yet often contaminated by sophisticated noise. Current denoising methods generally rely on independent and identically distributed noise…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Guangrui Ding , Chang Liu , Jiaze Yin , Xinyan Teng , Yuying Tan , Hongjian He , Haonan Lin , Lei Tian , Ji-Xin Cheng

Current self-supervised denoising methods for paired noisy images typically involve mapping one noisy image through the network to the other noisy image. However, after measuring the spectral bias of such methods using our proposed Image…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Wang Zhang , Huaqiu Li , Xiaowan Hu , Tao Jiang , Zikang Chen , Haoqian Wang

In many scientific applications, measured time series are corrupted by noise or distortions. Traditional denoising techniques often fail to recover the signal of interest, particularly when the signal-to-noise ratio is low or when certain…

Machine Learning · Computer Science 2022-11-02 Natalie Klein , Amber J. Day , Harris Mason , Michael W. Malone , Sinead A. Williamson

Removal or cancellation of noise has wide-spread applications for imaging and acoustics. In every-day-life applications, denoising may even include generative aspects, which are unfaithful to the ground truth. For scientific use, however,…

Sonar based audio classification techniques are a growing area of research in the field of underwater acoustics. Usually, underwater noise picked up by passive sonar transducers contains all types of signals that travel through the ocean…

Sound · Computer Science 2024-10-31 Noel Elias

Neural network (NN) based approaches for super-resolution MRI typically require high-SNR high-resolution reference data acquired in many subjects, which is time consuming and a barrier to feasible and accessible implementation. We propose…

Image and Video Processing · Electrical Eng. & Systems 2022-11-11 Jiaxin Xiao , Zihan Li , Berkin Bilgic , Jonathan R. Polimeni , Susie Huang , Qiyuan Tian

Speech super-resolution (SSR) aims to predict a high resolution (HR) speech signal from its low resolution (LR) corresponding part. Most neural SSR models focus on producing the final result in a noise-free environment by recovering the…

Audio and Speech Processing · Electrical Eng. & Systems 2023-10-11 Junkang Yang , Hongqing Liu , Lu Gan , Yi Zhou

Atomic resolution electron microscopy, particularly high-angle annular dark-field scanning transmission electron microscopy, has become an essential tool for many scientific fields, when direct visualization of atomic arrangements and…

Deep neural networks provide state-of-the-art performance for image denoising, where the goal is to recover a near noise-free image from a noisy observation. The underlying principle is that neural networks trained on large datasets have…

Information Theory · Computer Science 2019-04-09 Reinhard Heckel , Wen Huang , Paul Hand , Vladislav Voroninski
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