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In previous theoretical research, we inferred that cancer stem cells (CSCs), the cells that presumably drive tumor growth and resistance to conventional cancer treatments, are not uniformly distributed in the bulk of a tumorsphere. To…

Quantitative Methods · Quantitative Biology 2024-03-06 Jerónimo Fotinós , María Paula Marks , Lucas Barberis , Luciano Vellón

To date, the magnetic structure of nuclei has been poorly constrained, with limited information on its spatial distribution. In this work, we address the composition and distribution of nuclear magnetization in a precision study of…

We propose a new model to describe diffusion processes within active deformable media. Our general theoretical framework is based on physical and mathematical considerations, and it suggests to use diffusion tensors directly coupled to…

Tissues and Organs · Quantitative Biology 2021-03-03 Christian Cherubini , Simonetta Filippi , Alessio Gizzi , Ricardo Ruiz-Baier

We investigate how vibration affects molecular photoemission dynamics, through simulations on two-dimension asymmetric model molecules including the electronic and nuclear motions in a fully correlated way. We show that a slight anisotropy…

Chemical Physics · Physics 2024-02-14 Antoine Desrier , Morgan Berkane , Camille Lévêque , Richard Taïeb , Jérémie Caillat

We present an analytical theory for heteropolymer deformation, as exemplified experimentally by stretching of single protein molecules. Using a mean-field replica theory, we determine phase diagrams for stress-induced unfolding of typical…

Statistical Mechanics · Physics 2009-11-07 Phillip L. Geissler , Eugene I. Shakhnovich

The sensitivity--or rather insensitivity--of the elastic proton-nucleus reaction to the neutron radius of 208Pb is investigated using a non-relativistic impulse-approximation approach. The energy region (Tlab=500 MeV and Tlab=800 MeV) is…

Nuclear Theory · Physics 2009-11-11 J. Piekarewicz , S. P Weppner

Composite materials often exhibit mechanical anisotropy owing to the material properties or geometrical configurations of the microstructure. This makes their inverse design a two-fold problem. First, we must learn the type and orientation…

Computational Engineering, Finance, and Science · Computer Science 2024-12-19 Asghar A. Jadoon , Karl A. Kalina , Manuel K. Rausch , Reese Jones , Jan N. Fuhg

The mechanical environment of a substrate plays a key role in influencing the behavior of adherent biological cells. Traditional tunable substrates have limitations as their mechanical properties cannot be dynamically altered in-situ during…

Soft Condensed Matter · Physics 2025-11-12 Manu Sebastian , Sreenath Balakrishnan , Safvan Palathingal

The coupled-channel theory is a natural way of treating nonelastic channels, in particular those arising from collective excitations, defined by nuclear deformations. Proper treatment of such excitations is often essential to the accurate…

Nuclear Theory · Physics 2015-03-13 G. P. A. Nobre , F. S. Dietrich , M. Herman , A. Palumbo , S. Hoblit , D. Brown

Atomistic deformation simulations in the nominally elastic regime are performed for a model binary glass with strain rates as low as $10^{4}$/sec (corresponding to 0.01 shear strain per 1$\mu$sec). A robust elasticity is revealed that…

Soft Condensed Matter · Physics 2020-11-21 P. M. Derlet , R. Maass

A density dependent relativistic mean-field model is determined to reproduce the components of the nucleon self-energy at low densities. This model is used to investigate spinodal instabilities in isospin asymmetric nuclear matter at finite…

Nuclear Theory · Physics 2013-02-25 E. N. E. van Dalen , H. Müther

In this work we consider the inverse problem of reconstructing the optical properties of a layered medium from an elastography measurement where optical coherence tomography is used as the imaging method. We hereby model the sample as a…

Numerical Analysis · Mathematics 2024-02-23 Peter Elbau , Leonidas Mindrinos , Leopold Veselka

Large-angle elastic scattering of alpha-particle and strongly-bound light nuclei at a few tens MeV/nucleon has shown the pattern of rainbow scattering. This interesting process was shown to involve a significant overlap of the two colliding…

Nuclear Theory · Physics 2007-05-23 Dao T. Khoa , W. von Oertzen , H. G. Bohlen , H. S. Than

A conception of inhomogeneous locally random distribution of microdefects in crystalline solids is proposed. A method to calculate some physical properties of solids, containing inhomogeneously distributed defects, is developed. A…

Materials Science · Physics 2007-05-23 Yuri Kornyushin

Employing a recently-developed dispersive optical model (DOM) which allows a complete description of experimental data both above (up to 200 MeV) and below the Fermi energy in $^{40}$Ca, we demonstrate that elastic nucleon-nucleus…

Nuclear Theory · Physics 2015-02-20 H. Dussan , M. H. Mahzoon , R. J. Charity , W. H. Dickhoff , A. Polls

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

Image and Video Processing · Electrical Eng. & Systems 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Inverse protein folding is challenging due to its inherent one-to-many mapping characteristic, where numerous possible amino acid sequences can fold into a single, identical protein backbone. This task involves not only identifying viable…

Quantitative Methods · Quantitative Biology 2023-11-08 Kai Yi , Bingxin Zhou , Yiqing Shen , Pietro Liò , Yu Guang Wang

Nuclides sharing the same mass number (isobars) are observed ubiquitously along the stability line. While having nearly identical radii, stable isobars can differ in shape, and present in particular different quadrupole deformations. We…

Nuclear Theory · Physics 2021-11-03 Giuliano Giacalone , Jiangyong Jia , Vittorio Somà

The nuclear reactions in a plasma system with energy distribution deviated from Maxwellian are proved to have some unique characteristics including those in their product energy spectrum. Based on this, a new nuclear diagnostic scheme for…

Plasma Physics · Physics 2022-11-21 K. Li , Z. Y. Liu , A. D. Liu , B. Qiao

There have been suggestions to measure atomic parity nonconservation (PNC) along an isotopic chain, by taking ratios of observables in order to cancel complicated atomic structure effects. Precise atomic PNC measurements could make a…

Nuclear Theory · Physics 2008-11-26 S. J. Pollock , E. N. Fortson , L. Wilets
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