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Minfrared spectroscopic imaging (MIRSI) is an emerging class of label-free, biochemically quantitative technologies targeting digital histopathology. Conventional histopathology relies on chemical stains that alter tissue color. This…

Image and Video Processing · Electrical Eng. & Systems 2022-07-26 Mahsa Lotfollahi , Nguyen Tran , Sebastian Berisha , Chalapathi Gajjela , Zhu Han , David Mayerich , Rohith Reddy

Atomic force microscopy (AFM) is one of the most promising methods for investigating the structure of materials at the micro and nanoscale levels, as well as their local physical-mechanical properties. The experimental data obtained with…

Materials Science · Physics 2018-05-07 Oleg K. Garishin , Roman I. Izyumov , Alexander L. Svistkov

Measurements with an atomic force microscope (AFM) offer a direct way to probe elastic properties of lipid bilayer membranes locally: provided the underlying stress-strain relation is known, material parameters such as surface tension or…

Soft Condensed Matter · Physics 2007-05-23 Davood Norouzi , Martin Michael Mueller , Markus Deserno

We present an alternative approach to pump-probe spectroscopy for measuring fast charge dynamics with an atomic force microscope (AFM). Our approach is based on coherent multifrequency lock-in measurement of the intermodulation between a…

Mesoscale and Nanoscale Physics · Physics 2019-01-30 Riccardo Borgani , David B. Haviland

Mid-infrared photothermal microscopy is a highly promising imaging technique that enables spatially resolved vibrational fingerprinting. The combination of infrared induced heating with optical readout at visible wavelengths provides…

Optics · Physics 2025-08-05 Dennis van de Lockand , Daan Wolters , Matz Liebel

Resonant frequency modulation spectroscopy has been previously used as a highly-sensitive method for measuring the output of cold atom interferometers. Using a detailed model that accounts for optical saturation, laser intensities and…

Atomic Physics · Physics 2024-12-11 Ryan J. Thomas , Samuel R. Legge , Simon A. Haine , John D. Close

We present an imaging technique that allows the recovery of the transparency profile of wavelength-scale objects with deep subwavelength resolution based on far-field intensity measurements. The approach, interscale mixing microscopy (IMM),…

Optics · Physics 2017-03-21 Sandeep Inampudi , Nicholas Kuhta , Viktor A. Podolskiy

The paper describes the peculiarities of acquirement and interpretation of images of current distribution through the sample surface when operating in I-AFM mode. It shows that I-AFM and SCM modes can be successfully used only for small…

Instrumentation and Detectors · Physics 2020-12-15 Olga V. Sviridova

Infrared (IR) spectroscopy is an indispensable tool for many practical applications including material analysis and sensing. Existing IR spectroscopy techniques face challenges related to the inferior performance and the high cost of…

Optics · Physics 2017-03-13 Anna Paterova , Shaun Lung , Dmitry Kalashnikov , Leonid Krivitsky

Photothermal-Induced Resonance (PTIR) spectroscopy and imaging with infrared light has seen increasing application in molecular spectroscopy of biological samples. The appeal of the technique lies in its capability to provide information…

Quantitative Methods · Quantitative Biology 2019-11-19 Luca Quaroni

The functional properties of many technological surfaces in biotechnology, electronics, and mechanical engineering depend to a large degree on the individual features of their nanoscale surface texture, which in turn are a function of the…

FRET measurements can provide dynamic spatial information on length scales smaller than the diffraction limit of light. Several methods exist to measure FRET between fluorophores, including Fluorescence Lifetime Imaging Microscopy (FLIM),…

Quantitative Methods · Quantitative Biology 2017-01-09 Bryan Kaye , Peter J. Foster , Tae Yeon Yoo , Daniel J. Needleman

Contact Resonance Force Microscopy (CR-FM) is a leading AFM technique for measuring viscoelastic nano-mechanical properties. Conventional piezo-excited CR-FM measurements have been limited to imaging in air, since the "forest of peaks"…

Mesoscale and Nanoscale Physics · Physics 2014-10-14 Marta Kocun , Aleksander Labuda , Anil Gannepalli , Roger Proksch

While Atomic Force Microscopy is mostly used to investigate surface properties, people have almost since its invention sought to apply its high resolution capability to image also structures buried within samples. One of the earliest…

Over the course of the last decade, infrared (IR) and particularly thermal IR imaging based face recognition has emerged as a promising complement to conventional, visible spectrum based approaches which continue to struggle when applied in…

Computer Vision and Pattern Recognition · Computer Science 2013-06-10 Reza Shoja Ghiass , Ognjen Arandjelovic , Hakim Bendada , Xavier Maldague

Imaging of structural defects in a material can be realized with a radio-frequency atomic magnetometer by monitoring the material's response to a radio-frequency excitation field. We demonstrate two measurement configurations that enable…

Applied Physics · Physics 2019-03-27 P. Bevington , R. Gartman , W. Chalupczak

Atomic force microscopy (AFM) is an essential nanoinstrument technique for several applications such as cell biology and nanoelectronics metrology and inspection. The need for statistically significant sample sizes means that data…

Instrumentation and Detectors · Physics 2017-04-05 H. Sadeghian , R. Herfst , B. Dekker , J. Winters , T. Bijnagte , R. Rijnbeek

Field ion microscopy (FIM) allows to image individual surface atoms by exploiting the effect of an intense electric field. Widespread use of atomic resolution imaging by FIM has been hampered by a lack of efficient image processing/data…

Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a specimen. The performance, however, is limited in terms of spatial resolution and imaging speed. Here, instead of measuring the loss of the IR beam,…

Optics · Physics 2018-11-20 Yeran Bai , Delong Zhang , Lu Lan , Yimin Huang , Kerry Maize , Ali Shakouri , Ji-Xin Cheng

The ability to probe a materials electromechanical functionality on the nanoscale is critical to applications from energy storage and computing to biology and medicine. Voltage modulated atomic force microscopy (VM-AFM) has become a…

Mesoscale and Nanoscale Physics · Physics 2019-04-16 Liam Collins , Yongtao Liu , Olga Ovchinnikova , Roger Proksch
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