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Multimodal deep learning has shown strong potential in medical applications by integrating heterogeneous data sources such as medical images and structured clinical variables. However, most existing approaches implicitly assume complete…

Machine Learning · Computer Science 2026-05-13 Camillo Maria Caruso , Valerio Guarrasi , Paolo Soda

Multimodal clinical prediction faces three challenges: multiple foundation models (FMs) with complementary strengths per modality, pervasive missing modalities at training and test time, and sample-specific variation in modality…

Machine Learning · Computer Science 2026-05-19 Seungik Cho , Anqi Li , Wei Qiu

As medical diagnoses increasingly leverage multimodal data, machine learning models are expected to effectively fuse heterogeneous information while remaining robust to missing modalities. In this work, we propose a novel multimodal…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Yi Gu , Kuniaki Saito , Jiaxin Ma

Multi-modal fusion approaches aim to integrate information from different data sources. Unlike natural datasets, such as in audio-visual applications, where samples consist of "paired" modalities, data in healthcare is often collected…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Nasir Hayat , Krzysztof J. Geras , Farah E. Shamout

The combination of electronic health records (EHR) and medical images is crucial for clinicians in making diagnoses and forecasting prognosis. Strategically fusing these two data modalities has great potential to improve the accuracy of…

Image and Video Processing · Electrical Eng. & Systems 2024-10-24 Wenfang Yao , Kejing Yin , William K. Cheung , Jia Liu , Jing Qin

With the increasing availability of diverse data types, particularly images and time series data from medical experiments, there is a growing demand for techniques designed to combine various modalities of data effectively. Our motivation…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Ali Rasekh , Reza Heidari , Amir Hosein Haji Mohammad Rezaie , Parsa Sharifi Sedeh , Zahra Ahmadi , Prasenjit Mitra , Wolfgang Nejdl

Multi-disease diagnosis using multi-modal data like electronic health records and medical imaging is a critical clinical task. Although existing deep learning methods have achieved initial success in this area, a significant gap persists…

Multimedia · Computer Science 2025-09-22 Yueheng Jiang , Peng Zhang

A key challenge in learning from multimodal biological data is missing modalities, where data from one or more modalities are absent for some patients. Existing approaches either exclude patients with missing modalities, impute missing…

Machine Learning · Computer Science 2026-05-19 Sina Tabakhi , Chen , Chen , Haiping Lu

Machine learning holds promise for advancing clinical decision support, yet it remains unclear when multimodal learning truly helps in practice, particularly under modality missingness and fairness constraints. In this work, we conduct a…

Machine Learning · Computer Science 2026-03-02 Kejing Yin , Haizhou Xu , Wenfang Yao , Chen Liu , Zijie Chen , Yui Haang Cheung , William K. Cheung , Jing Qin

Multimodal data collected from the real world are often imperfect due to missing modalities. Therefore multimodal models that are robust against modal-incomplete data are highly preferred. Recently, Transformer models have shown great…

Computer Vision and Pattern Recognition · Computer Science 2022-04-13 Mengmeng Ma , Jian Ren , Long Zhao , Davide Testuggine , Xi Peng

Missing data is a common problem in machine learning and in retrospective imaging research it is often encountered in the form of missing imaging modalities. We propose to take into account missing modalities in the design and training of…

Computer Vision and Pattern Recognition · Computer Science 2019-09-26 Karin van Garderen , Marion Smits , Stefan Klein

Multi-modal medical images provide complementary soft-tissue characteristics that aid in the screening and diagnosis of diseases. However, limited scanning time, image corruption and various imaging protocols often result in incomplete…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Yue Zhang , Chengtao Peng , Qiuli Wang , Dan Song , Kaiyan Li , S. Kevin Zhou

Multimodal physiological data powers clinical AI systems from intensive care units to wearable devices, but sensors routinely fail in practice. Two failure modes are common: modality missing, where an entire channel is absent, and…

Machine Learning · Computer Science 2026-05-18 Wugeng Zheng , Ziwen Kan , Tianlong Chen , Chen Chen , Song Wang

Multimodal medical analysis combining image and tabular data has gained increasing attention. However, effective fusion remains challenging due to cross-modal discrepancies in feature dimensions and modality contributions, as well as the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Congjing Yu , Jing Ye , Yang Liu , Xiaodong Zhang , Zhiyong Zhang

Multi-modal learning has shown exceptional performance in various tasks, especially in medical applications, where it integrates diverse medical information for comprehensive diagnostic evidence. However, there still are several challenges…

Machine Learning · Computer Science 2024-11-19 Lin Fan , Yafei Ou , Cenyang Zheng , Pengyu Dai , Tamotsu Kamishima , Masayuki Ikebe , Kenji Suzuki , Xun Gong

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

Multimodal pathological images are usually in clinical diagnosis, but computer vision-based multimodal image-assisted diagnosis faces challenges with modality fusion, especially in the absence of expert-annotated data. To achieve the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Qinghua Lin , Guang-Hai Liu , Zuoyong Li , Yang Li , Yuting Jiang , Xiang Wu

In recent years, multi-modal fusion has attracted a lot of research interest, both in academia, and in industry. Multimodal fusion entails the combination of information from a set of different types of sensors. Exploiting complementary…

Machine Learning · Computer Science 2020-08-27 Siddharth Roheda , Hamid Krim , Benjamin S. Riggan

The acquisition of different data modalities can enhance our knowledge and understanding of various diseases, paving the way for a more personalized healthcare. Thus, medicine is progressively moving towards the generation of massive…

Image and Video Processing · Electrical Eng. & Systems 2024-05-06 Tiago Mota , M. Rita Verdelho , Alceu Bissoto , Carlos Santiago , Catarina Barata

Multimodal medical imaging plays a pivotal role in clinical diagnosis and research, as it combines information from various imaging modalities to provide a more comprehensive understanding of the underlying pathology. Recently, deep…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 Yihao Li , Mostafa El Habib Daho , Pierre-Henri Conze , Rachid Zeghlache , Hugo Le Boité , Ramin Tadayoni , Béatrice Cochener , Mathieu Lamard , Gwenolé Quellec
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