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Clinical research often focuses on complex traits in which many variables play a role in mechanisms driving, or curing, diseases. Clinical prediction is hard when data is high-dimensional, but additional information, like domain knowledge…

Methodology · Statistics 2020-05-21 Mirrelijn M. van Nee , Lodewyk F. A. Wessels , Mark A. van de Wiel

Linear mixed-effects models are widely used in analyzing clustered or repeated measures data. We propose a quasi-likelihood approach for estimation and inference of the unknown parameters in linear mixed-effects models with high-dimensional…

Methodology · Statistics 2021-03-10 Sai Li , Tony T. Cai , Hongzhe Li

Covariate-adaptive randomization is widely employed to balance baseline covariates in interventional studies such as clinical trials and experiments in development economics. Recent years have witnessed substantial progress in inference…

Methodology · Statistics 2024-05-30 Jiahui Xin , Hanzhong Liu , Wei Ma

In many problem settings, parameter vectors are not merely sparse but dependent in such a way that non-zero coefficients tend to cluster together. We refer to this form of dependency as "region sparsity." Classical sparse regression…

Machine Learning · Statistics 2019-01-28 Anqi Wu , Oluwasanmi Koyejo , Jonathan W. Pillow

This paper shows that the degree of approximate multicollinearity in a linear regression model increases simply by including independent variables, even if these are not highly linearly related. In the current situation where it is…

Methodology · Statistics 2025-03-07 Román Salmerón Gómez , Catalina García García

In randomized controlled trials without interference, regression adjustment is widely used to enhance the efficiency of treatment effect estimation. This paper extends this efficiency principle to settings with network interference, where a…

Methodology · Statistics 2025-02-18 Xinyuan Fan , Chenlei Leng , Weichi Wu

We develop an adaptive monotone shrinkage estimator for regression models with the following characteristics: i) dense coefficients with small but important effects; ii) a priori ordering that indicates the probable predictive importance of…

Methodology · Statistics 2015-05-08 Zhuang Ma , Dean Foster , Robert Stine

Meta-analysis is an important statistical technique for synthesizing the results of multiple studies regarding the same or closely related research question. So-called meta-regression extends meta-analysis models by accounting for…

Methodology · Statistics 2023-02-22 Thilo Welz , Eric S. Knop , Tim Friede , Markus Pauly

Consider a problem of predicting a response variable using a set of covariates in a linear regression model. If it is \emph{a priori} known or suspected that a subset of the covariates do not significantly contribute to the overall fit of…

Applications · Statistics 2011-09-13 SM Enayetur Raheem , S. Ejaz Ahmed

Usually, opinion formation models assume that individuals have an opinion about a given topic which can change due to interactions with others. However, individuals can have different opinions in different topics and therefore n-dimensional…

Physics and Society · Physics 2021-09-22 Lucia Pedraza , Juan Pablo Pinasco , Nicolas Saintier , Pablo Balenzuela

Shapley effects are attracting increasing attention as sensitivity measures. When the value function is the conditional variance, they account for the individual and higher order effects of a model input. They are also well defined under…

Computation · Statistics 2021-10-13 Elmar Plischke , Giovanni Rabitti , Emanuele Borgonovo

This study proposes a novel method for estimation and hypothesis testing in high-dimensional single-index models. We address a common scenario where the sample size and the dimension of regression coefficients are large and comparable.…

Statistics Theory · Mathematics 2024-04-30 Kazuma Sawaya , Yoshimasa Uematsu , Masaaki Imaizumi

Methods for choosing a fixed set of knot locations in additive spline models are fairly well established in the statistical literature. While most of these methods are in principle directly extendable to non-additive surface models, they…

Computation · Statistics 2018-07-03 Feng Li , Mattias Villani

Regression discontinuity designs are frequently used to estimate the causal effect of election outcomes and policy interventions. In these contexts, treatment effects are typically estimated with covariates included to improve efficiency.…

Applications · Statistics 2020-05-06 L. Jason Anastasopoulos

The extended class of multiplicative row-column (RC) association models, introduced in this paper for two-way contingency tables, allows users to select both the type of logit (local, global, continuation, reverse continuation) suitable for…

Computation · Statistics 2020-04-16 Antonio Forcina , Maria Kateri

Additive regression models are actively researched in the statistical field because of their usefulness in the analysis of responses determined by non-linear relationships with multivariate predictors. In this kind of statistical models,…

Methodology · Statistics 2018-04-10 German A. Schnaidt Grez , Brani Vidakovic

A common problem in health research is that we have a large database with many variables measured on a large number of individuals. We are interested in measuring additional variables on a subsample; these measurements may be newly…

Methodology · Statistics 2022-03-22 Thomas Lumley , Tong Chen

This paper studies the estimation of linear panel data models with interactive fixed effects, where one dimension of the panel, typically time, may be fixed. To this end, a novel transformation is introduced that reduces the model to a…

Econometrics · Economics 2021-10-13 Ayden Higgins

Causal inference, or counterfactual prediction, is central to decision making in healthcare, policy and social sciences. To de-bias causal estimators with high-dimensional data in observational studies, recent advances suggest the…

Machine Learning · Statistics 2020-10-20 Shuxi Zeng , Serge Assaad , Chenyang Tao , Shounak Datta , Lawrence Carin , Fan Li

The motivation of this article is to improve inferences on the covariation in environmental exposures, motivated by data from a study of Toddlers Exposure to SVOCs in Indoor Environments (TESIE). The challenge is that the sample size is…

Methodology · Statistics 2026-05-20 Elizabeth Bersson , Kate Hoffman , Heather M. Stapleton , David B. Dunson
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