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When the motion of a motile cell is observed closely, it appears erratic, and yet the combination of nonequilibrium forces and surfaces can produce striking examples of organization in microbial systems. While most of our current…

Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design…

Membrane phase-separation is a mechanism that biological membranes often use to locally concentrate specific lipid species in order to organize diverse membrane processes. Phase separation has also been explored as a tool for the design of…

Computational Physics · Physics 2020-06-26 Alexander Zhiliakov , Yifei Wang , Annalisa Quaini , Maxim Olshanskii , Sheereen Majd

A new numerical scheme is proposed for flow computation in complex discrete fracture networks. The method is based on a three-field formulation of the Darcy law for the description of the hydraulic head on the fractures and uses a cost…

Numerical Analysis · Mathematics 2019-12-23 Stefano Berrone , Denise Grappein , Sandra Pieraccini , Stefano Scialo

The use of floating bipolar electrodes in copper electro-winning cells represents an emerging technology that promises economic and operational impacts. This article presents a computational tool designed for the simulation and analysis of…

Graphics · Computer Science 2026-01-08 César Mena , Ricardo Sánchez , Lautaro Salazar

The shape of a microchannel during flow through it is instrumental to understanding the physics that govern various phenomena ranging from rheological measurements of fluids to separation of particles and cells. Two commonly used approaches…

The design of fluid channel structures of reactors or separators of chemical processes is key to enhancing the mass transfer processes inside the devices. However, the systematic design of channel topological structures is difficult for…

Fluid Dynamics · Physics 2025-03-07 Chenhui Kou , Yuhui Yin , Min Zhu , Shengkun Jia , Yiqing Luo , Xigang Yuana , Lu Lu

In chemotaxis, cells are modulating their migration patterns in response to concentration gradients of a guiding substance. Immune cells are believed to use such chemotactic sensing for remotely detecting and homing in on pathogens.…

Cell Behavior · Quantitative Biology 2019-02-28 Claus Metzner

This paper reports on the derivation and implementation of a shape optimization procedure for the minimization of hemolysis induction in biomedical devices. Hemolysis is a blood damaging phenomenon that may occur in mechanical…

Fluid Dynamics · Physics 2021-01-27 Georgios Bletsos , Niklas Kühl , Thomas Rung

Complex non-local behavior makes designing high efficiency and multifunctional metasurfaces a significant challenge. While using libraries of meta-atoms provide a simple and fast implementation methodology, pillar to pillar interaction…

This paper presents the shape optimization of a flat-type arborescent fluid distributor for the purpose of process intensification. A shape optimization algorithm based on the lattice Boltzmann method (LBM) is proposed with the objective of…

Fluid Dynamics · Physics 2014-06-20 Limin Wang , Yilin Fan , Lingai Luo

Developing a group of machine cells and their corresponding part families to minimize the inter-cell and intra-cell material flow is the basic objective of the designing of a cellular manufacturing system (CMS). Afterwards achieving a…

Computational Engineering, Finance, and Science · Computer Science 2012-12-21 T. Ghosh , P. K. Dan

Elementary flux modes (EFMs) are pathways through a metabolic reaction network that connect external substrates to products. Using EFMs, a metabolic network can be transformed into its macroscopic counterpart, in which the internal…

Optimization and Control · Mathematics 2014-10-13 Hildur Æsa Oddsdóttir , Erika Hagrot , Véronique Chotteau , Anders Forsgren

Topology optimization of microstructures plays a critical role in optimizing functional performance across diverse engineering applications. While metamaterials with enhanced mechanical properties -- such as hyperelasticity, energy…

Soft Condensed Matter · Physics 2025-01-27 Weiming Wang , Yanhao Hou , Renbo Su , Weiguang Wang , Charlie C. L. Wang

Spaces where each element describes a shape, so-called shape spaces, are of particular interest in shape optimization and its applications. Theory and algorithms in shape optimization are often based on techniques from differential…

Optimization and Control · Mathematics 2025-04-01 Lidiya Pryymak , Tim Suchan , Kathrin Welker

We present a new algorithm to design lightweight cellular materials with required properties in a multi-physics context. In particular, we focus on a thermo-mechanical setting, by promoting the design of unit cells characterized both by an…

Computational Engineering, Finance, and Science · Computer Science 2022-02-21 Matteo Gavazzoni , Nicola Ferro , Simona Perotto , Stefano Foletti

We introduce a general theoretical framework to study the shape dynamics of actively growing and remodeling surfaces. Using this framework we develop a physical model for growing bacterial cell walls and study the interplay of cell shape…

Biological Physics · Physics 2016-04-08 Shiladitya Banerjee , Norbert F. Scherer , Aaron R. Dinner

Electropermeabilization is a clinical technique in cancer treatment to locally stimulate the cell metabolism. It is based on electrical fields that change the properties of the cell membrane. With that, cancer treatment can reach the cell…

Analysis of PDEs · Mathematics 2016-03-03 Habib Ammari , Thomas Widlak , Wenlong Zhang

Electrochemical energy systems rely on particulate porous electrodes to store or convert energies. While the three-dimensional porous structures were introduced to maximize the interfacial area for better overall performance of the system,…

Applied Physics · Physics 2021-02-16 Shubham Agrawal , Peng Bai

The optical cross sections of plasmonic nanoparticles are intricately linked to the morphology of the particle. If this connection can be made accurately enough, it would become possible to determine a particles shape solely from its…