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Background: Perfusion computed tomography (CT) images the dynamics of a contrast agent through the body over time, and is one of the highest X-ray dose scans in medical imaging. Recently, a theoretically justified reconstruction algorithm…

Medical Physics · Physics 2026-02-04 Namhoon Kim , Ashwin Pananjady , Amir Pourmorteza , Sara Fridovich-Keil

X-ray computed tomography (CT) based on photon counting detectors (PCD) extends standard CT by counting detected photons in multiple energy bins. PCD data can be used to increase the contrast-to-noise ratio (CNR), increase spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-02-05 Natalie M. Jadue , Madhuri Nagare , Jonathan S. Maltz , Gregery T. Buzzard , Charles A. Bouman

Quantitative estimation of contrast agent concentration is made possible by spectral CT and material decomposition. There are several approaches to modulate the sensitivity of the imaging system to obtain the different spectral channels…

Medical Physics · Physics 2020-10-16 Matthew Tivnan , Wenying Wang , Grace Gang , Eleni Liapi , Peter Noel , J. Webster Stayman

While Model Based Iterative Reconstruction (MBIR) of CT scans has been shown to have better image quality than Filtered Back Projection (FBP), its use has been limited by its high computational cost. More recently, deep convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2018-12-21 Amirkoushyar Ziabari , Dong Hye Ye , Somesh Srivastava , Ken D. Sauer , Jean-Baptiste Thibault , Charles A. Bouman

Inferior soft-tissue contrast resolution is a major limitation of current CT scanners. The aim of the study is to improve the contrast resolution of CT scanners using dual-energy acquisition. Based on dual-energy material decomposition, the…

Medical Physics · Physics 2016-11-15 Wei Zhao , Lu Wan , Bo Zhang , Qiude Zhang , Tianye Niu

Spectral computed tomography based on a photon-counting detector (PCD) attracts more and more attentions since it has the capability to provide more accurate identification and quantitative analysis for biomedical materials. The limited…

Image and Video Processing · Electrical Eng. & Systems 2023-11-17 Xiaodong Guo , Longhui Li , Dingyue Chang , Peng He , Peng Feng , Hengyong Yu , Weiwen Wu

Spectral computed tomography (CT) has attracted much attention in radiation dose reduction, metal artifacts removal, tissue quantification and material discrimination. The x-ray energy spectrum is divided into several bins, each…

Image and Video Processing · Electrical Eng. & Systems 2021-08-26 Weiwen Wu , Dianlin Hu , Chuang Niu , Lieza Vanden Broeke , Anthony P. H. Butler , Peng Cao , James Atlas , Alexander Chernoglazov , Varut Vardhanabhuti , Ge Wang

X-Ray based computed tomography (CT) is a well-established technique for determining the three-dimensional structure of an object from its two-dimensional projections. In the past few decades, there have been significant advancements in the…

Medical Physics · Physics 2023-04-26 Dinesh Kumar , Dilworth Y. Parkinson , Jeffrey J. Donatelli

Photon counting detectors (PCDs) offer promising advancements in computed tomography (CT) imaging by enabling the quantification and 3D imaging of contrast agents and tissue types through multi-energy projections. However, the accuracy of…

Medical Physics · Physics 2023-10-18 Juan C. R. Luna , Mini Das

In this paper, we present a deep learning algorithm to rapidly obtain high quality CT reconstructions for AM parts. In particular, we propose to use CAD models of the parts that are to be manufactured, introduce typical defects and simulate…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Amirkoushyar Ziabari , Michael Kirka , Vincent Paquit , Philip Bingham , Singanallur Venkatakrishnan

The potential huge advantage of spectral computed tomography (CT) is its capability to provide accuracy material identification and quantitative tissue information. This can benefit clinical applications, such as brain angiography, early…

Image and Video Processing · Electrical Eng. & Systems 2020-08-18 Weiwen Wu , Haijun Yu , Peijun Chen , Fulin Luo , Fenglin Liu , Qian Wang , Yining Zhu , Yanbo Zhang , Jian Feng , Hengyong Yu

Computed Tomography (CT) reconstruction of objects with cylindrical symmetry can be performed with a single projection. When the measured rays are parallel, and the axis of symmetry is perpendicular to the optical axis, the data can be…

Medical Physics · Physics 2024-10-15 Kyle M. Champley , Ibrahim Oksuz , Matthew G. Bisbee , Joseph W. Tringe , Brian Maddox

The recent application of Fourier Based Iterative Reconstruction Method (FIRM) has made it possible to achieve high-quality 2D images from a fan beam Computed Tomography (CT) scan with a limited number of projections in a fast manner. The…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 N. Teyfouri , H. Rabbani , R. Kafieh , Iraj Jabbari

Spectral computed tomography (CT) has a great potential in material identification and decomposition. To achieve high-quality material composition images and further suppress the x-ray beam hardening artifacts, we first propose a one-step…

Computer Vision and Pattern Recognition · Computer Science 2020-01-08 Weiwen Wu , Qian Wang , Fenglin Liu , Yining Zhu , Hengyong Yu

Model-Based Iterative Reconstruction (MBIR) is important because direct methods, such as Filtered Back-Projection (FBP) can introduce significant noise and artifacts in sparse-angle tomography, especially for time-evolving samples. Although…

Mathematical Software · Computer Science 2026-03-31 Dinesh Kumar , Jeffrey Donatelli

Spectral photon-counting X-ray CT (sCT) opens up new possibilities for the quantitative measurement of materials in an object, compared to conventional energy-integrating CT or dual energy CT. However, achieving reliable and accurate…

Image and Video Processing · Electrical Eng. & Systems 2020-07-15 Bingqing Xie , Pei Niu , Ting Su , Valérie Kaftandjian , Loic Boussel , Philippe Douek Feng Yang , Philippe Duvauchelle , Yuemin Zhu

In this study we evaluated the task-based image quality of a low contrast clinical task for the abdomen protocol (e.g., pancreatic tumour) of three different CT vendors, exploiting three model-based iterative reconstruction (MBIR) levels.…

Medical Physics · Physics 2023-01-23 G. Muti , S. Riga , L. Berta , D. Curto , C. De Mattia , M. Felisi , F. Rizzetto , A. Torresin , A. Vanzulli , P. E. Colombo

For single source helical Computed Tomography (CT), both Filtered-Back Projection (FBP) and statistical iterative reconstruction have been investigated. However for dual source CT with flying focal spot (DS-FFS CT), statistical iterative…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Xiao Wang , Robert D. MacDougall , Peng Chen , Charles A. Bouman , Simon K. Warfield

Spectral CT offers enhanced material discrimination over single-energy systems and enables quantitative estimation of basis material density images. Water/iodine decomposition in contrast-enhanced CT is one of the most widespread…

Medical Physics · Physics 2021-03-30 Matthew Tivnan , Grace Gang , Wenchao Cao , Nadav Shapira , Peter B. Noel , J. Webster Stayman

Many clinical applications depend critically on the accurate differentiation and classification of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and…

Medical Physics · Physics 2018-03-19 Wei Zhao , Don Vernekohl , Fei Han , Bin Han , Hao Peng , Lei Xing , James K Min
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