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We consider the problem of multiple hypothesis testing with generic side information: for each hypothesis $H_i$ we observe both a p-value $p_i$ and some predictor $x_i$ encoding contextual information about the hypothesis. For large-scale…

Methodology · Statistics 2018-07-26 Lihua Lei , William Fithian

Evaluating the joint significance of covariates is of fundamental importance in a wide range of applications. To this end, p-values are frequently employed and produced by algorithms that are powered by classical large-sample asymptotic…

Methodology · Statistics 2017-05-11 Yingying Fan , Emre Demirkaya , Jinchi Lv

\noindent Hyper-parameter selection is a central practical problem in modern machine learning, governing regularization strength, model capacity, and robustness choices. Cross-validation is often computationally prohibitive at scale, while…

Machine Learning · Statistics 2025-12-24 Hedibert Lopes , Nick Polson , Vadim Sokolov

Many applications involve data with qualitative and quantitative responses. When there is an association between the two responses, a joint model will provide improved results than modeling them separately. In this paper, we propose a…

Methodology · Statistics 2026-05-12 Xiaoning Kang , Shyam Ranganathan , Lulu Kang , Julia Gohlke , Xinwei Deng

We consider the joint inference of regression coefficients and the inverse covariance matrix for covariates in high-dimensional probit regression, where the predictors are both relevant to the binary response and functionally related to one…

Methodology · Statistics 2022-03-15 Xuan Cao , Kyoungjae Lee

Bayesian analyses are often performed using so-called noninformative priors, with a view to achieving objective inference about unknown parameters on which available data depends. Noninformative priors depend on the relationship of the data…

Methodology · Statistics 2013-08-14 Nicholas Lewis

We consider the problem of comparing two Poisson parameters from the Bayesian perspective. Kawasaki and Miyaoka (2012b) proposed the Bayesian index $P(\lambda_1 < \lambda_2 | X_1,X_2)$ and expressed it using the hypergeometric series. In…

Methodology · Statistics 2016-06-07 Masaaki Doi

A new approach for Bayesian model averaging (BMA) and selection is proposed, based on the mixture model approach for hypothesis testing in Kaniav et al., 2014. Inheriting from the good properties of this approach, it extends BMA to cases…

Methodology · Statistics 2018-08-02 Merlin Keller , Kaniav Kamary

The proposed approach extends the confidence posterior distribution to the semi-parametric empirical Bayes setting. Whereas the Bayesian posterior is defined in terms of a prior distribution conditional on the observed data, the confidence…

Methodology · Statistics 2012-05-02 David R. Bickel

This article develops $p$-values for evaluating means of normal populations that make use of indirect or prior information. A $p$-value of this type is based on a biased test statistic that is optimal on average with respect to a…

Methodology · Statistics 2019-12-12 Peter D. Hoff

The large-scale multiple testing inherent to high throughput biological data necessitates very high statistical stringency and thus true effects in data are difficult to detect unless they have high effect sizes. One solution to this…

Methodology · Statistics 2017-12-21 Mohamad S. Hasan

Unblinded sample size re-estimation (SSR) is often planned in a clinical trial when there is large uncertainty about the true treatment effect. For Proof-of Concept (PoC) in a Phase II dose finding study, contrast test can be adopted to…

Methodology · Statistics 2022-11-11 Qingyang Liu , Guanyu Hu , Binqi Ye , Susan Wang , Yaoshi Wu

When using mixture models it may be the case that the modeller has a-priori beliefs or desires about what the components of the mixture should represent. For example, if a mixture of normal densities is to be fitted to some data, it may be…

Methodology · Statistics 2011-07-28 Matthew Sperrin

In various biomedical studies, analysis often focuses on data magnitudes, particularly when algebraic signs are irrelevant or lost. For repeated measures studies involving magnitude outcomes, incorporating random effects is essential as…

Methodology · Statistics 2025-07-16 Wen Teng , Niall D. Ferguson , Ewan C. Goligher , Anna Heath

We consider a novel paradigm for Bayesian testing of hypotheses and Bayesian model comparison. Our alternative to the traditional construction of posterior probabilities that a given hypothesis is true or that the data originates from a…

Methodology · Statistics 2019-01-01 Kaniav Kamary , Kerrie Mengersen , Christian P. Robert , Judith Rousseau

A/B tests are typically analyzed via frequentist p-values and confidence intervals; but these inferences are wholly unreliable if users endogenously choose samples sizes by *continuously monitoring* their tests. We define *always valid*…

Statistics Theory · Mathematics 2019-07-18 Ramesh Johari , Leo Pekelis , David J. Walsh

To extract bulk QGP properties, we perform a joint Bayesian calibration of bulk-medium parameters using low-$\pt$ bulk and high-$\pt$ tomography within a common medium evolution. Low-$\pt$ observables are computed with…

High Energy Physics - Phenomenology · Physics 2026-03-11 Marko Djordjevic , Dusan Zigic , Igor Salom , Magdalena Djordjevic

The Zellner's g-prior and its recent hierarchical extensions are the most popular default prior choices in the Bayesian variable selection context. These prior set-ups can be expressed power-priors with fixed set of imaginary data. In this…

Computation · Statistics 2013-07-10 Dimitris Fouskakis , Ioannis Ntzoufras

Multiple testing of a single hypothesis and testing multiple hypotheses are usually done in terms of p-values. In this paper we replace p-values with their natural competitor, e-values, which are closely related to betting, Bayes factors,…

Statistics Theory · Mathematics 2021-10-26 Vladimir Vovk , Ruodu Wang

Conjugate priors allow for fast inference in large dimensional vector autoregressive (VAR) models but, at the same time, introduce the restriction that each equation features the same set of explanatory variables. This paper proposes a…

Econometrics · Economics 2020-08-27 Niko Hauzenberger , Florian Huber , Luca Onorante