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We demonstrate that deep learning techniques can be used to predict motility induced phase separation (MIPS) in suspensions of active Brownian particles (ABPs) by creating a notion of phase at the particle level. Using a fully connected…

Soft Condensed Matter · Physics 2020-11-19 Austin R. Dulaney , John F. Brady

Active systems comprise a class of nonequilibrium dynamics in which individual components autonomously dissipate energy. Efforts towards understanding the role played by activity have centered on computation of the entropy production rate…

Statistical Mechanics · Physics 2024-11-22 Nicholas M. Boffi , Eric Vanden-Eijnden

Active matter systems operate far from equilibrium due to the continuous energy injection at the scale of constituent particles. At larger scales, described by coarse-grained models, the global entropy production rate S quantifies the…

Statistical Mechanics · Physics 2017-04-26 Cesare Nardini , Etienne Fodor , Elsen Tjhung , Frederic van Wijland , Julien Tailleur , Michael E. Cates

Time-reversal symmetry breaking and entropy production are universal features of nonequilibrium phenomena. Despite its importance in the physics of active and living systems, the entropy production of systems with many degrees of freedom…

We present an active learning framework for efficiently generating training data for machine-learned interatomic potentials (MLIPs). The method combines local entropy-driven molecular dynamics with global dataset-aware filtering: a…

Materials Science · Physics 2026-05-21 Meiyan Wang , Rishi Rao , Li Zhu

Collections of self-propelled particles that move persistently by continuously consuming free energy are a paradigmatic example of active matter. In these systems, unlike Brownian "hot colloids", the breakdown of detailed balance yields a…

Soft Condensed Matter · Physics 2018-09-12 Suraj Shankar , M. Cristina Marchetti

Motility-induced phase separation (MIPS) is a paradigmatic non-equilibrium transition in active matter, determined by the P\'eclet number and packing fraction. We investigate the single-phase and phase-separated regimes of MIPS using a…

Biological Physics · Physics 2025-10-03 Italo Salas , Francisca Guzmán-Lastra , Denisse Pastén , Ariel Norambuena

We examine motility-induced phase separation (MIPS) in two-dimensional run and tumble disk systems using both machine learning and noise fluctuation analysis. Our measures suggest that within the MIPS state there are several distinct…

Soft Condensed Matter · Physics 2024-04-23 D. McDermott , C. Reichhardt , C. J. O. Reichhardt

The limits of molecular dynamics (MD) simulations of macromolecules are steadily pushed forward by the relentless developments of computer architectures and algorithms. This explosion in the number and extent (in size and time) of MD…

We introduce the so called DeepParticle method to learn and generate invariant measures of stochastic dynamical systems with physical parameters based on data computed from an interacting particle method (IPM). We utilize the expressiveness…

Machine Learning · Computer Science 2022-06-22 Zhongjian Wang , Jack Xin , Zhiwen Zhang

Active matter systems being in a non-equilibrium state, exhibit complex behaviors such as self-organization and giving rise to emergent phenomena. There are many examples of active particles with biological origins, including bacteria and…

Soft Condensed Matter · Physics 2024-04-15 Abdolhalim Torrik , Mahdi Zarif

The aim of this paper is to discuss the mathematical modeling of Brownian active particle systems, a recently popular paradigmatic system for self-propelled particles. We present four microscopic models with different types of repulsive…

Statistical Mechanics · Physics 2022-05-31 M. Bruna , M. Burger , A. Esposito , S. M. Schulz

The dynamic of complex ordering systems with active rotational degrees of freedom exemplified by protein self-assembly is explored using a machine learning workflow that combines deep learning-based semantic segmentation and rotationally…

Soft Condensed Matter · Physics 2021-04-26 Sergei V. Kalinin , Shuai Zhang , Mani Valleti , Harley Pyles , David Baker , James J. De Yoreo , Maxim Ziatdinov

Active matter has been intensely studied for its wealth of intriguing properties such as collective motion, motility-induced phase separation (MIPS), and giant fluctuations away from criticality. However, the precise connection of active…

Statistical Mechanics · Physics 2019-04-17 Juliane U. Klamser , Sebastian C. Kapfer , Werner Krauth

Quantifying entropy production in various active matter phases will open new avenues for probing self-organization principles in these far-from-equilibrium systems. It has been hypothesized that the dissipation of free energy by active…

Biological Physics · Physics 2019-03-27 Carlos Floyd , Garegin A. Papoian , Christopher Jarzynski

Configurational entropy is an important factor in the free energy change of many macromolecular recognition and binding processes, and has been intensively studied. Despite great progresses that have been made, the global sampling remains…

Biological Physics · Physics 2012-12-04 Wenzhao Li , Kai Wang , Suyan Tian , Pu Tian

Entropy production is a universal measure of irreversibility and energy dissipation in physical, chemical, and biological systems operating far from equilibrium. However, quantifying and spatiotemporally localising it in complex processes…

Statistical Mechanics · Physics 2026-05-18 Biswajit Das , Sreekanth K Manikandan

We use a combination of unsupervised clustering and sparsity-promoting inference algorithms to learn locally dominant force balances that explain macroscopic pattern formation in self-organized active particle systems. The self-organized…

Soft Condensed Matter · Physics 2023-07-28 Dominik Sturm , Suryanarayana Maddu , Ivo F. Sbalzarini

Characterizing the entropy of a system is a crucial, and often computationally costly, step in understanding its thermodynamics. It plays a key role in the study of phase transitions, pattern formation, protein folding and more. Current…

Statistical Mechanics · Physics 2020-12-02 Amit Nir , Eran Sela , Roy Beck , Yohai Bar-Sinai

Collectives of actively-moving particles can spontaneously segregate into dilute and dense phases through a process known as motility-induced phase separation (MIPS). This captivating phenomenon is well-studied for randomly-moving particles…

Soft Condensed Matter · Physics 2026-03-04 Hongbo Zhao , Qiwei Yu , Andrej Košmrlj , Sujit S. Datta
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