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We are interested in estimating the effect of a treatment applied to individuals at multiple sites, where data is stored locally for each site. Due to privacy constraints, individual-level data cannot be shared across sites; the sites may…

Machine Learning · Computer Science 2023-04-04 Ruoxuan Xiong , Allison Koenecke , Michael Powell , Zhu Shen , Joshua T. Vogelstein , Susan Athey

Federated learning of causal estimands may greatly improve estimation efficiency by leveraging data from multiple study sites, but robustness to heterogeneity and model misspecifications is vital for ensuring validity. We develop a…

Methodology · Statistics 2023-10-06 Larry Han , Jue Hou , Kelly Cho , Rui Duan , Tianxi Cai

Deep learning models have shown their advantage in many different tasks, including neuroimage analysis. However, to effectively train a high-quality deep learning model, the aggregation of a significant amount of patient information is…

Machine Learning · Computer Science 2020-12-08 Xiaoxiao Li , Yufeng Gu , Nicha Dvornek , Lawrence Staib , Pamela Ventola , James S. Duncan

Analyzing data from multiple sources offers valuable opportunities to improve the estimation efficiency of causal estimands. However, this analysis also poses many challenges due to population heterogeneity and data privacy constraints.…

Methodology · Statistics 2025-10-23 Rong Zhao , Jason Falvey , Xu Shi , Vernon M. Chinchilli , Chixiang Chen

One-shot federated learning enables multi-site inference with minimal communication. However, sharing summary statistics can still leak sensitive individual-level information when sites have only a small number of patients. In particular,…

Methodology · Statistics 2026-04-02 Keisuke Hanada , Toshio Shimokawa , Kazushi Maruo

Federated causal inference enables multi-site treatment effect estimation without sharing individual-level data, offering a privacy-preserving solution for real-world evidence generation. However, data heterogeneity across sites, manifested…

Machine Learning · Computer Science 2025-05-06 Haoyang Li , Jie Xu , Kyra Gan , Fei Wang , Chengxi Zang

Federated learning of causal estimands offers a powerful strategy to improve estimation efficiency by leveraging data from multiple study sites while preserving privacy. Existing literature has primarily focused on the average treatment…

Methodology · Statistics 2025-11-24 Siqi Cao , Shu Yang

Causal inference typically assumes centralized access to individual-level data. Yet, in practice, data are often decentralized across multiple sites, making centralization infeasible due to privacy, logistical, or legal constraints. We…

Methodology · Statistics 2026-02-04 Rémi Khellaf , Aurélien Bellet , Julie Josse

Causal inference across multiple data sources offers a promising avenue to enhance the generalizability and replicability of scientific findings. However, data integration methods for time-to-event outcomes, common in biomedical research,…

Methodology · Statistics 2025-05-16 Yi Liu , Alexander W. Levis , Ke Zhu , Shu Yang , Peter B. Gilbert , Larry Han

Collaboration between different data centers is often challenged by heterogeneity across sites. To account for the heterogeneity, the state-of-the-art method is to re-weight the covariate distributions in each site to match the distribution…

Machine Learning · Statistics 2024-04-25 Tianyu Guo , Sai Praneeth Karimireddy , Michael I. Jordan

Synthesizing information from multiple data sources is critical to ensure knowledge generalizability. Integrative analysis of multi-source data is challenging due to the heterogeneity across sources and data-sharing constraints due to…

Methodology · Statistics 2023-01-03 Zijian Guo , Xiudi Li , Larry Han , Tianxi Cai

Federated Learning using the Federated Averaging algorithm has shown great advantages for large-scale applications that rely on collaborative learning, especially when the training data is either unbalanced or inaccessible due to privacy…

Machine Learning · Computer Science 2021-07-21 Jonatan Reyes , Lisa Di Jorio , Cecile Low-Kam , Marta Kersten-Oertel

Machine learning methods for estimating heterogeneous treatment effects (HTE) facilitate large-scale personalized decision-making across various domains such as healthcare, policy making, education, and more. Current machine learning…

Machine Learning · Computer Science 2024-06-25 Disha Makhija , Joydeep Ghosh , Yejin Kim

Federated learning provides a communication-efficient and privacy-preserving training process by enabling learning statistical models with massive participants while keeping their data in local clients. However, standard federated learning…

Machine Learning · Computer Science 2022-07-15 Shenghui Li , Edith Ngai , Fanghua Ye , Thiemo Voigt

Empirical risk minimization often performs poorly when the distribution of the target domain differs from those of source domains. To address such potential distribution shifts, we develop an unsupervised domain adaptation approach that…

Machine Learning · Statistics 2025-03-25 Zhenyu Wang , Peter Bühlmann , Zijian Guo

Patient privacy is a major barrier to healthcare AI. For confidentiality reasons, most patient data remains in silo in separate hospitals, preventing the design of data-driven healthcare AI systems that need large volumes of patient data to…

Machine Learning · Computer Science 2023-10-11 Tatsuki Koga , Kamalika Chaudhuri , David Page

In Federated Learning (FL), the distributed nature and heterogeneity of client data present both opportunities and challenges. While collaboration among clients can significantly enhance the learning process, not all collaborations are…

Machine Learning · Computer Science 2024-07-18 Nazarii Tupitsa , Samuel Horváth , Martin Takáč , Eduard Gorbunov

In the era of big data, the explosive growth of multi-source heterogeneous data offers many exciting challenges and opportunities for improving the inference of conditional average treatment effects. In this paper, we investigate…

Machine Learning · Statistics 2022-11-02 Xinyu Li , Yilin Li , Qing Cui , Longfei Li , Jun Zhou

Federated learning faces huge challenges from model overfitting due to the lack of data and statistical diversity among clients. To address these challenges, this paper proposes a novel personalized federated learning method via Bayesian…

Machine Learning · Computer Science 2022-06-17 Xu Zhang , Yinchuan Li , Wenpeng Li , Kaiyang Guo , Yunfeng Shao

One of the most challenging issues in federated learning is that the data is often not independent and identically distributed (nonIID). Clients are expected to contribute the same type of data and drawn from one global distribution.…

Machine Learning · Computer Science 2024-01-08 Hung Nguyen , Peiyuan Wu , Morris Chang
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