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Large Language Models (LLMs) have exhibited remarkable proficiency in comprehending and generating natural language. On the other hand, personalized LLM response generation holds the potential to offer substantial benefits for individuals…

Computation and Language · Computer Science 2025-01-15 Kai Zhang , Yejin Kim , Xiaozhong Liu

Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools…

With the rapid development of large language models, AI assistants like ChatGPT have become increasingly integrated into people's works and lives but are limited in personalized services. In this paper, we present a plug-and-play framework…

Computation and Language · Computer Science 2024-10-15 Ruifeng Yuan , Shichao Sun , Yongqi Li , Zili Wang , Ziqiang Cao , Wenjie Li

The entry of large language models (LLMs) into research and commercial spaces has led to a trend of ever-larger models, with initial promises of generalisability, followed by a widespread desire to downsize and create specialised models…

Computation and Language · Computer Science 2024-02-19 Niall Taylor , Upamanyu Ghose , Omid Rohanian , Mohammadmahdi Nouriborji , Andrey Kormilitzin , David Clifton , Alejo Nevado-Holgado

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

One-size-fits-all large language models (LLMs) are increasingly being used to help people with their writing. However, the style these models are trained to write in may not suit all users or use cases. LLMs would be more useful as writing…

Computation and Language · Computer Science 2024-09-10 Xinyue Liu , Harshita Diddee , Daphne Ippolito

With the continuous growth in the number of parameters of transformer-based pretrained language models (PLMs), particularly the emergence of large language models (LLMs) with billions of parameters, many natural language processing (NLP)…

Computation and Language · Computer Science 2023-12-20 Lingling Xu , Haoran Xie , Si-Zhao Joe Qin , Xiaohui Tao , Fu Lee Wang

Large language models (LLMs) increasingly serve as the central control unit of AI agents, yet current approaches remain limited in their ability to deliver personalized interactions. While Retrieval Augmented Generation enhances LLM…

Artificial Intelligence · Computer Science 2025-10-10 Rebecca Westhäußer , Wolfgang Minker , Sebatian Zepf

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

Despite its substantial impact on various search, recommendation, and question answering tasks, privacy-preserving methods for personalizing large language models (LLMs) have received relatively limited exploration. There is one primary…

Computation and Language · Computer Science 2025-06-27 Alireza Salemi , Hamed Zamani

Large Language Models (LLMs) are composed of neurons that exhibit various behaviors and roles, which become increasingly diversified as models scale. Recent studies have revealed that not all neurons are active across different datasets,…

Computation and Language · Computer Science 2024-03-19 Haoyun Xu , Runzhe Zhan , Derek F. Wong , Lidia S. Chao

Personalized large language models (LLMs) tailor content to individual preferences using user profiles or histories. However, existing parameter-efficient fine-tuning (PEFT) methods, such as the ``One-PEFT-Per-User'' (OPPU) paradigm,…

Computation and Language · Computer Science 2025-10-21 Zhaoxuan Tan , Zixuan Zhang , Haoyang Wen , Zheng Li , Rongzhi Zhang , Pei Chen , Fengran Mo , Zheyuan Liu , Qingkai Zeng , Qingyu Yin , Meng Jiang

Multimodal Large Language Models (MLLMs) serve as daily assistants for millions. However, their ability to generate responses aligned with individual preferences remains limited. Prior approaches enable only static, single-turn…

Computation and Language · Computer Science 2026-04-16 Chang Nie , Chaoyou Fu , Yifan Zhang , Haihua Yang , Caifeng Shan

Pre-trained language models (PLMs) show impressive performance in various downstream NLP tasks. However, pre-training large language models demands substantial memory and training compute. Furthermore, due to the substantial resources…

Computation and Language · Computer Science 2024-04-01 HyunJin Kim , Young Jin Kim , JinYeong Bak

The rapid development of large language models (LLMs) has transformed many industries, including healthcare. However, previous medical LLMs have largely focused on leveraging general medical knowledge to provide responses, without…

Computation and Language · Computer Science 2024-12-23 Ruize Shi , Hong Huang , Wei Zhou , Kehan Yin , Kai Zhao , Yun Zhao

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

The recent emergence of Large Language Models (LLMs) has heralded a new era of human-AI interaction. These sophisticated models, exemplified by Chat-GPT and its successors, have exhibited remarkable capabilities in language understanding.…

Computation and Language · Computer Science 2024-07-26 Christopher Clarke , Yuzhao Heng , Lingjia Tang , Jason Mars

High-throughput phenotyping, the automated mapping of patient signs and symptoms to standardized ontology concepts, is essential to gaining value from electronic health records (EHR) in the support of precision medicine. Despite…

Artificial Intelligence · Computer Science 2024-06-24 Syed I. Munzir , Daniel B. Hier , Chelsea Oommen , Michael D. Carrithers

Parameter-Efficient Fine-tuning (PEFT) facilitates the fine-tuning of Large Language Models (LLMs) under limited resources. However, the fine-tuning performance with PEFT on complex, knowledge-intensive tasks is limited due to the…

Computation and Language · Computer Science 2024-06-10 Jitai Hao , WeiWei Sun , Xin Xin , Qi Meng , Zhumin Chen , Pengjie Ren , Zhaochun Ren
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