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We consider the problem of olfactory searches in a turbulent environment. We focus on agents that respond solely to odor stimuli, with no access to spatial perception nor prior information about the odor. We ask whether navigation to a…

Biological Physics · Physics 2025-01-29 Marco Rando , Martin James , Alessandro Verri , Lorenzo Rosasco , Agnese Seminara

The olfactory system employs responses of an ensemble of odorant receptors (ORs) to sense molecules and to generate olfactory percepts. Here we hypothesized that ORs can be viewed as 3D spatial filters that extract molecular features…

Machine Learning · Computer Science 2024-12-13 Sergey Shuvaev , Khue Tran , Khristina Samoilova , Cyrille Mascart , Alexei Koulakov

Our sense of smell relies on sensitive, selective atomic-scale processes that are initiated when a scent molecule meets specific receptors in the nose. However, the physical mechanisms of detection are not clear. While odorant shape and…

Biological Physics · Physics 2015-06-26 Jennifer C. Brookes , Filio Hartoutsiou , A. P. Horsfield , A. M. Stoneham

This research introduces a Machine Learning-centric approach to replicate olfactory experiences, validated through experimental quantification of perfume perception. Key contributions encompass a hybrid model connecting perfume molecular…

Predicting olfactory perception directly from molecular structure is central to fragrance design that plays a role in a wide range of industries, such as perfumery, food and beverage, and health care. Among olfactory attributes, odor…

Chemical Physics · Physics 2026-05-18 Peter Fichtelmann , Julia Westermayr

We present a model for olfactory coding based on spatial representation of glomerular responses. In this model distinct odorants activate specific subsets of glomeruli, dependent upon the odorant's chemical identity and concentration. The…

Neurons and Cognition · Quantitative Biology 2007-05-23 A. Koulakov , A. Gelperin , D. Rinberg

In recent years, more machine learning algorithms have been applied to odor classification. These odor classification algorithms usually assume that the training datasets are static. However, for some odor recognition tasks, new odor…

Machine Learning · Computer Science 2019-04-30 Yu Cheng , Angus Wong , Kevin Hung , Zhizhong Li , Weitong Li , Jun Zhang

We seek to (i) characterize the learning architectures exploited in biological neural networks for training on very few samples, and (ii) port these algorithmic structures to a machine learning context. The Moth Olfactory Network is among…

Machine Learning · Computer Science 2019-01-29 Charles B. Delahunt , J. Nathan Kutz

Odor visualization translates odor information and perception into visual outcomes and arouses the corresponding olfactory synesthesia, surpassing the spatial limitation that odors can only be perceived where they are present. Traditional…

Human-Computer Interaction · Computer Science 2026-02-05 Gang Yu , Yuchi Sun , Weining Yan , Xinyu Wang , Qi Lu

In this paper we construct a learning architecture for high dimensional time series sampled by sensor arrangements. Using a redundant wavelet decomposition on a graph constructed over the sensor locations, our algorithm is able to construct…

Artificial Intelligence · Computer Science 2016-02-16 Leonid Gugel , Yoel Shkolnisky , Shai Dekel

Machine olfaction is rapidly emerging as a transformative capability, with applications spanning non-invasive medical diagnostics, industrial monitoring, agriculture, and security and defense. Recent advances in stabilizing mammalian…

Mitral cells, the principal neurons in the olfactory bulb, respond to odorants by firing bursts of action potentials called sharp events. A given cell produces a sharp event at a fixed phase during the sniff cycle in response to a given…

Neurons and Cognition · Quantitative Biology 2014-07-02 Honi Sanders , Brian Kolterman , Roman Shusterman , Dmitry Rinberg , Alexei A. Koulakov , John Lisman

This study introduces an artificial neural network (ANN) for image classification task, inspired by the aversive olfactory learning circuits of the nematode Caenorhabditis elegans (C. elegans). Despite the remarkable performance of ANNs in…

Neural and Evolutionary Computing · Computer Science 2024-09-13 Xuebin Wang , Chunxiuzi Liu , Meng Zhao , Ke Zhang , Zengru Di , He Liu

The mammalian olfactory system learns rapidly from very few examples, presented in unpredictable online sequences, and then recognizes these learned odors under conditions of substantial interference without exhibiting catastrophic…

Neural and Evolutionary Computing · Computer Science 2019-07-15 Ayon Borthakur , Thomas A. Cleland

The insect olfactory system, which includes the antennal lobe (AL), mushroom body (MB), and ancillary structures, is a relatively simple neural system capable of learning. Its structural features, which are widespread in biological neural…

Neurons and Cognition · Quantitative Biology 2018-02-09 Charles B. Delahunt , Jeffrey A. Riffell , J. Nathan Kutz

Here we introduce the Olfactory Perception (OP) benchmark, designed to assess the capability of large language models (LLMs) to reason about smell. The benchmark contains 1,010 questions across eight task categories spanning odor…

Computation and Language · Computer Science 2026-04-02 Eftychia Makri , Nikolaos Nakis , Laura Sisson , Gigi Minsky , Leandros Tassiulas , Vahid Satarifard , Nicholas A. Christakis

In the olfactory system, odor percepts retain their identity despite substantial variations in concentration, timing, and background. We propose a novel strategy for encoding intensity-invariant stimuli identity that is based on…

Neurons and Cognition · Quantitative Biology 2016-09-09 Daniel Kepple , Hamza Giaffar , Dmitry Rinberg , Alexei Koulakov

Olfactory receptor usage is highly heterogeneous, with some receptor types being orders of magnitude more abundant than others. We propose an explanation for this striking fact: the receptor distribution is tuned to maximally represent…

Neurons and Cognition · Quantitative Biology 2019-01-23 Tiberiu Tesileanu , Simona Cocco , Remi Monasson , Vijay Balasubramanian

Molecular odor prediction is the process of using a molecule's structure to predict its smell. While accurate prediction remains challenging, AI models can suggest potential odors. Existing methods, however, often rely on basic descriptors…

Machine Learning · Computer Science 2025-05-02 Hong Xin Xie , Jian De Sun , Fan Fu Xue , Zi Fei Han , Shan Shan Feng , Qi Chen

Classical computing is beginning to encounter fundamental limits of energy efficiency. This presents a challenge that can no longer be solved by strategies such as increasing circuit density or refining standard semiconductor processes. The…

Hardware Architecture · Computer Science 2026-04-07 Keshava Katti , Pratik Chaudhari , Deep Jariwala