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Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

Deep neural networks suffer from significant performance deterioration when there exists distribution shift between deployment and training. Domain Generalization (DG) aims to safely transfer a model to unseen target domains by only relying…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Xin Zhang , Ying-Cong Chen

In this work, we investigate the unexplored intersection of domain generalization (DG) and data-free learning. In particular, we address the question: How can knowledge contained in models trained on different source domains be merged into…

Machine Learning · Computer Science 2022-11-15 Ahmed Frikha , Haokun Chen , Denis Krompaß , Thomas Runkler , Volker Tresp

Domain Generalization (DG) studies the capability of a deep learning model to generalize to out-of-training distributions. In the last decade, literature has been massively filled with training methodologies that claim to obtain more…

Computer Vision and Pattern Recognition · Computer Science 2023-05-10 Simone Angarano , Mauro Martini , Francesco Salvetti , Vittorio Mazzia , Marcello Chiaberge

Background: Image classification can be considered one of the key pillars of medical image analysis. Deep learning (DL) faces challenges that prevent its practical applications despite the remarkable improvement in medical image…

Image and Video Processing · Electrical Eng. & Systems 2026-02-19 Shahabedin Nabavi , Kian Anvari Hamedani , Mohsen Ebrahimi Moghaddam , Ahmad Ali Abin , Alejandro F. Frangi

Domain generalization (DG) aims to improve the generalization performance for an unseen target domain by using the knowledge of multiple seen source domains. Mainstream DG methods typically assume that the domain label of each source sample…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Chaoqi Chen , Jiongcheng Li , Xiaoguang Han , Xiaoqing Liu , Yizhou Yu

The generalization capability of machine learning models, which refers to generalizing the knowledge for an "unseen" domain via learning from one or multiple seen domain(s), is of great importance to develop and deploy machine learning…

Machine Learning · Computer Science 2022-02-17 Keyu Chen , Di Zhuang , J. Morris Chang

Domain Generalization is a challenging topic in computer vision, especially in Gastrointestinal Endoscopy image analysis. Due to several device limitations and ethical reasons, current open-source datasets are typically collected on a…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Weichen Fan , Yuanbo Yang , Kunpeng Qiu , Shuo Wang , Yongxin Guo

Domain generalization (DG) is the challenging and topical problem of learning models that generalize to novel testing domains with different statistics than a set of known training domains. The simple approach of aggregating data from all…

Computer Vision and Pattern Recognition · Computer Science 2019-12-09 Da Li , Jianshu Zhang , Yongxin Yang , Cong Liu , Yi-Zhe Song , Timothy M. Hospedales

To generalize the model trained in source domains to unseen target domains, domain generalization (DG) has recently attracted lots of attention. Since target domains can not be involved in training, overfitting source domains is inevitable.…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Jian Zhang , Lei Qi , Yinghuan Shi , Yang Gao

Single-source domain generalization (SDG) in medical image segmentation is a challenging yet essential task as domain shifts are quite common among clinical image datasets. Previous attempts most conduct global-only/random augmentation.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Zixian Su , Kai Yao , Xi Yang , Qiufeng Wang , Jie Sun , Kaizhu Huang

Typical machine learning frameworks heavily rely on an underlying assumption that training and test data follow the same distribution. In medical imaging which increasingly begun acquiring datasets from multiple sites or scanners, this…

Computer Vision and Pattern Recognition · Computer Science 2021-02-18 Xingchen Zhao , Anthony Sicilia , Davneet Minhas , Erin O'Connor , Howard Aizenstein , William Klunk , Dana Tudorascu , Seong Jae Hwang

With the prevalence of Diabetes, the Diabetes Mellitus Retinopathy (DR) is becoming a major health problem across the world. The long-term medical complications arising due to DR have a significant impact on the patient as well as the…

Computer Vision and Pattern Recognition · Computer Science 2022-01-04 Shreyas Rajesh Labhsetwar , Raj Sunil Salvi , Piyush Arvind Kolte , Veerasai Subramaniam venkatesh , Alistair Michael Baretto

Domain generalization refers to the problem where we aim to train a model on data from a set of source domains so that the model can generalize to unseen target domains. Naively training a model on the aggregate set of data (pooled from all…

Machine Learning · Computer Science 2022-02-16 A. Tuan Nguyen , Toan Tran , Yarin Gal , Atılım Güneş Baydin

Learning the ability to generalize knowledge between similar contexts is particularly important in medical imaging as data distributions can shift substantially from one hospital to another, or even from one machine to another. To…

Computer Vision and Pattern Recognition · Computer Science 2023-11-13 Steven Korevaar , Ruwan Tennakoon , Ricky O'Brien , Dwarikanath Mahapatra , Alireza Bab-Hadiasha

Distributional shift between domains poses great challenges to modern machine learning algorithms. The domain generalization (DG) signifies a popular line targeting this issue, where these methods intend to uncover universal patterns across…

Computer Vision and Pattern Recognition · Computer Science 2023-10-05 Hao Chen , Qi Zhang , Zenan Huang , Haobo Wang , Junbo Zhao

Machine learning models fail to perform when facing out-of-distribution (OOD) domains, a challenging task known as domain generalization (DG). In this work, we develop a novel DG training strategy, we call PGrad, to learn a robust gradient…

Machine Learning · Computer Science 2023-05-03 Zhe Wang , Jake Grigsby , Yanjun Qi

Domain shift, caused by variations in imaging modalities and acquisition protocols, limits model generalization in medical image segmentation. While foundation models (FMs) trained on diverse large-scale data hold promise for zero-shot…

Computer Vision and Pattern Recognition · Computer Science 2025-04-01 Soumitri Chattopadhyay , Basar Demir , Marc Niethammer

Domain Generalization (DG) is a critical area that focuses on developing models capable of performing well on data from unseen distributions, which is essential for real-world applications. Existing approaches primarily concentrate on…

Machine Learning · Computer Science 2026-01-28 Xudong Han , Senkang Hu , Yihang Tao , Yu Guo , Philip Birch , Sam Tak Wu Kwong , Yuguang Fang

Human visual perception can easily generalize to out-of-distributed visual data, which is far beyond the capability of modern machine learning models. Domain generalization (DG) aims to close this gap, with existing DG methods mainly…

Computer Vision and Pattern Recognition · Computer Science 2023-01-30 Bo Li , Yifei Shen , Jingkang Yang , Yezhen Wang , Jiawei Ren , Tong Che , Jun Zhang , Ziwei Liu