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Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…
Accurately predicting drug responses to cancer is an important problem hindering oncologists' efforts to find the most effective drugs to treat cancer, which is a core goal in precision medicine. The scientific community has focused on…
Intensity modulated proton therapy (IMPT) provides highly conformal dose distributions through the application of multiple, angularly spaced fields, each applying an ad-hoc pattern of spatially varying particle fluences. In particular,…
Simulated annealing tomography (SAT) is a simple iterative image reconstruction technique which can yield a superior reconstruction compared with filtered back-projection (FBP). However, the very high computational cost of iteratively…
Uncompressed clinical data from modern positron emission tomography (PET) scanners are very large, exceeding 350 million data points (projection bins). The last decades have seen tremendous advancements in mathematical imaging tools many of…
We consider the effects of parameter uncertainty on the optimal radiation schedule in the context of the linear-quadratic model. Our interest arises from the observation that if inter-patient variations in OAR and tumor sensitivities to…
Proton computed tomography (pCT) is a novel imaging modality developed for patients receiving proton radiation therapy. The purpose of this work was to investigate hull-detection algorithms used for preconditioning of the large and sparse…
With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…
Ion beam therapy has become a frequently applied form of cancer therapy over the last years. The advantage of ion beam therapy over conventional radiotherapy using photons is the strongly localized dose deposition, leading to a reduction of…
Currently, there is a high interest in Lu-177 targeted radionuclide therapies, which could be attributed to favourable results obtained from Lu-177 compounds targeting neuroendocrine and prostate tumours. Generally, it has been recognized…
In photoacoustic tomography (PAT), the computation of the initial pressure distribution within an object from its time-dependent boundary measurements over time is considered. This problem can be approached from two well-established points…
Pancreas stereotactic body radiotherapy treatment planning requires planners to make sequential, time consuming interactions with the treatment planning system (TPS) to reach the optimal dose distribution. We seek to develop a reinforcement…
Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…
Volumetric Modulated Arc Therapy (VMAT) is a cornerstone of modern radiation therapy, enabling highly conformal tumor irradiation and healthy-tissue sparing. Yet, its planning solves inverse and nested optimization for multi-leaf…
High-quality proton beams generated by laser-plasma interactions are of significant interest for applications ranging from tumor therapy to fast ignition in inertial confinement fusion. However, simultaneously achieving high energy coupling…
Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…
Next generation radio-interferometers, like the Square Kilometre Array, will acquire tremendous amounts of data with the goal of improving the size and sensitivity of the reconstructed images by orders of magnitude. The efficient processing…
The differential sparing of normal tissues relative to tumor control observed at ultra-high dose rates, referred to as the FLASH effect, has recently gained considerable attention. The therapeutic advantages of FLASH radiotherapy are…
Electroporation (EP), the temporary or permanent permeabilization of the cell membrane induced by an electric field, is the basis of various applications in medicine and food processing. In EP-based protocol optimization in terms of pulse…
Traffic optimization challenges, such as load balancing, flow scheduling, and improving packet delivery time, are difficult online decision-making problems in wide area networks (WAN). Complex heuristics are needed for instance to find…