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Antinuclear antibody (ANA) testing is a crucial method for diagnosing autoimmune disorders, including lupus, Sj\"ogren's syndrome, and scleroderma. Despite its importance, manual ANA detection is slow, labor-intensive, and demands years of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Yiyang Jiang , Guangwu Qian , Jiaxin Wu , Qi Huang , Qing Li , Yongkang Wu , Xiao-Yong Wei

Missing data represents a fundamental challenge in machine learning applications, often reducing model performance and reliability. This problem is particularly acute in fields like bioinformatics and clinical machine learning, where…

Machine Learning · Computer Science 2025-09-04 Fatemeh Azad , Zoran Bosnić , Matjaž Kukar

Information on the number and category of cervical cells is crucial for the diagnosis of cervical cancer. However, existing classification methods capable of automatically measuring this information require the training dataset to be…

Computer Vision and Pattern Recognition · Computer Science 2025-08-18 Yuanlin Liu , Zhihan Zhou , Mingqiang Wei , Youyi Song

Multimodal image-tabular learning is gaining attention, yet it faces challenges due to limited labeled data. While earlier work has applied self-supervised learning (SSL) to unlabeled data, its task-agnostic nature often results in learning…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Siyi Du , Xinzhe Luo , Declan P. O'Regan , Chen Qin

Convolutional Dictionary Learning (CDL) has emerged as a powerful approach for signal representation by learning translation-invariant features through convolution operations. While existing CDL methods are predominantly designed and used…

Signal Processing · Electrical Eng. & Systems 2025-05-22 Hao Chen , Dayuan Tan

Cancer is a leading cause of death in many countries. An early diagnosis of cancer based on biomedical imaging ensures effective treatment and a better prognosis. However, biomedical imaging presents challenges to both clinical institutions…

Computer Vision and Pattern Recognition · Computer Science 2023-01-24 Hosein Barzekar , Yash Patel , Ling Tong , Zeyun Yu

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

Image and Video Processing · Electrical Eng. & Systems 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

Microscopy images contain rich information about how cells respond to perturbations, making them essential to applications like drug screening. To quantify images, researchers often use representation extraction methods, and recent years…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Emre Hayir , Lorin Crawford , Alex X. Lu

Machine learning-based multi-label medical text classifications can be used to enhance the understanding of the human body and aid the need for patient care. We present a broad study on clinical natural language processing techniques to…

Information Retrieval · Computer Science 2020-04-02 Vithya Yogarajan , Jacob Montiel , Tony Smith , Bernhard Pfahringer

The visual examination of tissue biopsy sections is fundamental for cancer diagnosis, with pathologists analyzing sections at multiple magnifications to discern tumor cells and their subtypes. However, existing attention-based multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Olga Fourkioti , Matt De Vries , Chen Jin , Daniel C. Alexander , Chris Bakal

Automated disease diagnosis using medical image analysis relies on deep learning, often requiring large labeled datasets for supervised model training. Diseases like Acute Myeloid Leukemia (AML) pose challenges due to scarce and costly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Salome Kazeminia , Max Joosten , Dragan Bosnacki , Carsten Marr

Cell image classification methods are currently being used in numerous applications in cell biology and medicine. Applications include understanding the effects of genes and drugs in screening experiments, understanding the role and…

Quantitative Methods · Quantitative Biology 2022-03-04 Mohammad Shifat-E-Rabbi , Xuwang Yin , Cailey Elizabeth Fitzgerald , Gustavo K. Rohde

Deep learning methods have played a more and more important role in hyperspectral image classification. However, the general deep learning methods mainly take advantage of the information of sample itself or the pairwise information between…

Computer Vision and Pattern Recognition · Computer Science 2021-03-30 Zhiqiang Gong , Weidong Hu , Xiaoyong Du , Ping Zhong , Panhe Hu

Self-supervised pretraining followed by supervised fine-tuning has seen success in image recognition, especially when labeled examples are scarce, but has received limited attention in medical image analysis. This paper studies the…

Whole slide image (WSI) assessment is a challenging and crucial step in cancer diagnosis and treatment planning. WSIs require high magnifications to facilitate sub-cellular analysis. Precise annotations for patch- or even pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Simon Holdenried-Krafft , Peter Somers , Ivonne A. Montes-Majarro , Diana Silimon , Cristina Tarín , Falko Fend , Hendrik P. A. Lensch

Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide.Multi-modal MRI data is crucial for accurate brain tumor segmentation, but missing modalities common in clinical practice can severely…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Bingcang Huang , Kai Chen , Lin Gu , Zhe Wang , Sai Wu , Chang Yao

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

Deep learning methodologies have been employed in several different fields, with an outstanding success in image recognition applications, such as material quality control, medical imaging, autonomous driving, etc. Deep learning models rely…

Computer Vision and Pattern Recognition · Computer Science 2022-03-11 Saul Calderon-Ramirez , Shengxiang Yang , David Elizondo

Identification and counting of cells and mitotic figures is a standard task in diagnostic histopathology. Due to the large overall cell count on histological slides and the potential sparse prevalence of some relevant cell types or mitotic…

Computer Vision and Pattern Recognition · Computer Science 2017-09-08 Marc Aubreville , Maximilian Krappmann , Christof Bertram , Robert Klopfleisch , Andreas Maier

This paper proposes an introspective deep metric learning (IDML) framework for uncertainty-aware comparisons of images. Conventional deep metric learning methods focus on learning a discriminative embedding to describe the semantic features…

Computer Vision and Pattern Recognition · Computer Science 2023-09-20 Chengkun Wang , Wenzhao Zheng , Zheng Zhu , Jie Zhou , Jiwen Lu