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Sickle Cell Disease (SCD) is a hereditary disorder of red blood cells in humans. Complications such as pain, stroke, and organ failure occur in SCD as malformed, sickled red blood cells passing through small blood vessels get trapped.…
Beneficial reversals of dominance reduce the costs of genetic trade-offs and can enable selection to maintain genetic variation for fitness. Beneficial dominance reversals are characterized by the beneficial allele for a given context (e.g.…
Rheumatoid arthritis is a chronic autoimmune disease that is a major public health challenge. The disease is characterised by inflammation of synovial joints and cartilage erosion, which leads to chronic pain, poor life quality and, in some…
Introduction Schizophrenia is a severe mental disorder, and early diagnosis is key to improving outcomes. Its complexity makes predicting onset and progression challenging. EEG has emerged as a valuable tool for studying schizophrenia, with…
While noise is generally associated with uncertainties and often has a negative connotation in engineering, living organisms have evolved to adapt to (and even exploit) such uncertainty to ensure the survival of a species or implement…
Cognizance of gene-environment interactions may help prevent or detain the onset of complex diseases like cardiovascular disease, cancer, type2 diabetes, autism or asthma by adjustments to lifestyle. In this regard, we extend the Bayesian…
Human life expectancy has dramatically improved over the course of the last century. Although this reflects a global improvement in sanitation and medical care, this also implies that more people suffer from diseases that typically manifest…
Back pain is one of the leading causes of disability-adjusted life year globally and the most common cause of low back pain is poor sitting posture. There are several actions that can be adopted proactively to avoid poor sitting posture…
Phylogenetic analyses of gene expression have great potential for addressing a wide range of questions. These analyses will, for example, identify genes that have evolutionary shifts in expression that are correlated with evolutionary…
Profound vitamin B12 deficiency is a known cause of disease, but the role of low or intermediate levels of B12 in the development of neuropathy and other neuropsychiatric symptoms as well as the relationship of eating meat and B12 levels is…
Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline…
In spite of years of research, the mechanisms that underlie the development of schizophrenia, as well as its relapse, symptomatology, and treatment, continue to be a mystery. The absence of appropriate analytic tools to deal with the…
Cells often exhibit different and stable phenotypes from the same DNA sequence. Robustness and plasticity of such cellular states are controlled by diverse transcriptional and epigenetic mechanisms, among them the modification of…
Healthcare professionals have long envisioned using the enormous processing powers of computers to discover new facts and medical knowledge locked inside electronic health records. These vast medical archives contain time-resolved…
Estimation of heterogeneous treatment effects is an active area of research. Most of the existing methods, however, focus on estimating the conditional average treatment effects of a single, binary treatment given a set of pre-treatment…
Knee osteoarthritis (KOA) affects more than 600 million individuals globally and is associated with significant pain, functional impairment, and disability. While personalized multidisciplinary interventions have the potential to slow…
This study employs a robust analytical framework to uncover patterns in survival outcomes among breast cancer patients from diverse racial and geographical backgrounds. This research uses the SEER 2021 dataset to analyze breast cancer…
Ageing of society and increase of time spent with chronic conditions challenge the traditional long-term care model. Assistive technology and eHealth are seen to play an important role when addressing these challenges. One prominent example…
Epilepsy is a neurological disorder characterized by seizures and epileptic events intertwined with religious and personal beliefs since prehistoric times. This review paper explores the historical context and challenges in defining…
The emergence of and transitions between distinct phenotypes in isogenic cells can be attributed to the intricate interplay of epigenetic marks, external signals, and gene regulatory elements. These elements include chromatin remodelers,…