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Applied researchers in biomedicine and related fields are often interested in estimating the causal effect of a treatment or intervention. Although randomized clinical trials are considered the gold standard for establishing causal effects,…

This paper considers how to classify the effects of interventions in causal models for outcomes and exposures observed over time. First, we demonstrate the limitations of the most common uses of potential outcomes and causal directed…

Methodology · Statistics 2026-05-29 Russell Steele , Naftali Weinberger , Tess Baker , Ian Shrier

Estimating an individual's counterfactual outcomes under interventions is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, facial images) and…

Machine Learning · Computer Science 2025-03-19 Yulun Wu , Louie McConnell , Claudia Iriondo

In general relativity, the causal structure between events is dynamical, but it is definite and observer-independent; events are point-like and the membership of an event A in the future or past light-cone of an event B is an…

Quantum Physics · Physics 2020-07-13 Philippe Allard Guérin , Časlav Brukner

Practitioners making decisions based on causal effects typically ignore structural uncertainty. We analyze when this uncertainty is consequential enough to warrant methodological solutions (Bayesian model averaging over competing causal…

Machine Learning · Computer Science 2025-08-01 Maurits Kaptein

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing…

Methodology · Statistics 2020-02-10 Liuyi Yao , Zhixuan Chu , Sheng Li , Yaliang Li , Jing Gao , Aidong Zhang

This article contributes to the discussion on the relationship between the Neyman-Rubin and the graphical frameworks for causal inference. We present specific examples of data-generating mechanisms - such as those involving undirected or…

Methodology · Statistics 2025-12-11 Tetiana Gorbach , Xavier de Luna , Juha Karvanen , Ingeborg Waernbaum

We consider the task of causal imputation, where we aim to predict the outcomes of some set of actions across a wide range of possible contexts. As a running example, we consider predicting how different drugs affect cells from different…

Machine Learning · Statistics 2024-09-19 Alvaro Ribot , Chandler Squires , Caroline Uhler

We extend two kinds of causal models, structural equation models and simulation models, to infinite variable spaces. This enables a semantics for conditionals founded on a calculus of intervention, and axiomatization of causal reasoning for…

Artificial Intelligence · Computer Science 2021-06-03 Duligur Ibeling , Thomas Icard

We study causal inference in settings characterized by interference with a bipartite structure. There are two distinct sets of units: intervention units to which an intervention can be applied and outcome units on which the outcome of…

Methodology · Statistics 2025-07-29 Georgia Papadogeorgou , Zhaoyan Song , Guido Imbens , Fabrizia Mealli

Using a process-theoretic formalism, we introduce the notion of a causal-inferential theory: a triple consisting of a theory of causal influences, a theory of inferences (of both the Boolean and Bayesian varieties), and a specification of…

Quantum Physics · Physics 2021-05-21 David Schmid , John H. Selby , Robert W. Spekkens

The interpretability of prediction mechanisms with respect to the underlying prediction problem is often unclear. While several studies have focused on developing prediction models with meaningful parameters, the causal relationships…

Machine Learning · Statistics 2017-09-05 Patrick Blöbaum , Shohei Shimizu

Researchers are often challenged with assessing the impact of an intervention on an outcome of interest in situations where the intervention is non-randomised, the intervention is only applied to one or few units, the intervention is…

Counterfactual explanation methods interpret the outputs of a machine learning model in the form of "what-if scenarios" without compromising the fidelity-interpretability trade-off. They explain how to obtain a desired prediction from the…

Machine Learning · Computer Science 2021-08-19 Peyman Rasouli , Ingrid Chieh Yu

Intervention intuition is often used in model explanation where the intervention effect of a feature on the outcome is quantified by the difference of a model prediction when the feature value is changed from the current value to the…

Machine Learning · Computer Science 2024-10-22 Debo Cheng , Ziqi Xu , Jiuyong Li , Lin Liu , Kui Yu , Thuc Duy Le , Jixue Liu

Discussions on causal relations in real life often consider variables for which the definition of causality is unclear since the notion of interventions on the respective variables is obscure. Asking 'what qualifies an action for being an…

Methodology · Statistics 2022-11-17 Dominik Janzing , Sergio Hernan Garrido Mejia

Causal inference on multiple non-independent outcomes raises serious challenges, because multivariate techniques that properly account for the outcome's dependence structure need to be considered. We focus on the case of binary outcomes…

Methodology · Statistics 2018-05-11 Monia Lupparelli , Alessandra Mattei

For obtaining causal inferences that are objective, and therefore have the best chance of revealing scientific truths, carefully designed and executed randomized experiments are generally considered to be the gold standard. Observational…

Applications · Statistics 2008-11-12 Donald B. Rubin

Counterfactual frameworks have grown popular in machine learning for both explaining algorithmic decisions but also defining individual notions of fairness, more intuitive than typical group fairness conditions. However, state-of-the-art…

Artificial Intelligence · Computer Science 2023-01-09 Lucas de Lara , Alberto González-Sanz , Nicholas Asher , Laurent Risser , Jean-Michel Loubes

In this paper we look at popular fairness methods that use causal counterfactuals. These methods capture the intuitive notion that a prediction is fair if it coincides with the prediction that would have been made if someone's race, gender…

Machine Learning · Statistics 2022-12-12 Jake Fawkes , Robin Evans , Dino Sejdinovic
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