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Magnetic resonance imaging (MRI) has played a crucial role in fetal neurodevelopmental research. Structural annotations of MR images are an important step for quantitative analysis of the developing human brain, with Deep Learning providing…

We present a deep learning strategy that enables, for the first time, contrast-agnostic semantic segmentation of completely unpreprocessed brain MRI scans, without requiring additional training or fine-tuning for new modalities. Classical…

Image and Video Processing · Electrical Eng. & Systems 2021-04-09 Benjamin Billot , Douglas Greve , Koen Van Leemput , Bruce Fischl , Juan Eugenio Iglesias , Adrian V. Dalca

Despite advances in data augmentation and transfer learning, convolutional neural networks (CNNs) difficultly generalise to unseen domains. When segmenting brain scans, CNNs are highly sensitive to changes in resolution and contrast: even…

Image and Video Processing · Electrical Eng. & Systems 2023-03-01 Benjamin Billot , Douglas N. Greve , Oula Puonti , Axel Thielscher , Koen Van Leemput , Bruce Fischl , Adrian V. Dalca , Juan Eugenio Iglesias

Segmentation of fetal brain tissue from magnetic resonance imaging (MRI) plays a crucial role in the study of in utero neurodevelopment. However, automated tools face substantial domain shift challenges as they must be robust to highly…

Image and Video Processing · Electrical Eng. & Systems 2024-10-15 Vladyslav Zalevskyi , Thomas Sanchez , Margaux Roulet , Jordina Aviles Verddera , Jana Hutter , Hamza Kebiri , Meritxell Bach Cuadra

Deep learning approaches to the segmentation of magnetic resonance images have shown significant promise in automating the quantitative analysis of brain images. However, a continuing challenge has been its sensitivity to the variability of…

Image and Video Processing · Electrical Eng. & Systems 2021-03-05 Dzung L. Pham , Yi-Yu Chou , Blake E. Dewey , Daniel S. Reich , John A. Butman , Snehashis Roy

A large amount of manual segmentation is typically required to train a robust segmentation network so that it can segment objects of interest in a new imaging modality. The manual efforts can be alleviated if the manual segmentation in one…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Bo Zhou , Chi Liu , James S. Duncan

Generative AI models hold great potential in creating synthetic brain MRIs that advance neuroimaging studies by, for example, enriching data diversity. However, the mainstay of AI research only focuses on optimizing the visual quality (such…

Image and Video Processing · Electrical Eng. & Systems 2023-10-10 Wei Peng , Tomas Bosschieter , Jiahong Ouyang , Robert Paul , Ehsan Adeli , Qingyu Zhao , Kilian M. Pohl

Retrospective analysis of brain MRI scans acquired in the clinic has the potential to enable neuroimaging studies with sample sizes much larger than those found in research datasets. However, analysing such clinical images "in the wild" is…

Image and Video Processing · Electrical Eng. & Systems 2023-01-06 Benjamin Billot , Magdamo Colin , Sean E. Arnold , Sudeshna Das , Juan. E. Iglesias

Domain randomization through synthesis is a powerful strategy to train networks that are unbiased with respect to the domain of the input images. Randomization allows networks to see a virtually infinite range of intensities and artifacts…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Xiaoling Hu , Xiangrui Zeng , Oula Puonti , Juan Eugenio Iglesias , Bruce Fischl , Yael Balbastre

Fetal brain magnetic resonance imaging serves as an emerging modality for prenatal counseling and diagnosis in disorders affecting the brain. Machine learning based segmentation plays an important role in the quantification of brain…

Image and Video Processing · Electrical Eng. & Systems 2022-09-21 Marina Fernandez Garcia , Rodrigo Gonzalez Laiz , Hui Ji , Kelly Payette , Andras Jakab

Purpose: This study demonstrated an MR signal multitask learning method for 3D simultaneous segmentation and relaxometry of human brain tissues. Materials and Methods: A 3D inversion-prepared balanced steady-state free precession sequence…

Medical Physics · Physics 2019-12-02 Peng Cao , Jing Liu , Shuyu Tang , Andrew Leynes , Janine M. Lupo , Duan Xu , Peder E. Z. Larson

In this study, we develop a physics-informed deep learning-based method to synthesize multiple brain magnetic resonance imaging (MRI) contrasts from a single five-minute acquisition and investigate its ability to generalize to arbitrary…

Synthetic training has recently advanced brain MRI segmentation by enabling contrast-agnostic models trained entirely on generated data. However, most existing approaches rely on hundreds of automatically labeled templates, introducing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Romain Valabregue , Ines Khemir , Eric Badinet , François Rousseau , Guillaume Auzias , Reuben Dorent

In our comprehensive experiments and evaluations, we show that it is possible to generate multiple contrast (even all synthetically) and use synthetically generated images to train an image segmentation engine. We showed promising…

Image and Video Processing · Electrical Eng. & Systems 2022-07-07 Ismail Irmakci , Zeki Emre Unel , Nazli Ikizler-Cinbis , Ulas Bagci

Fetal brain tissue segmentation in magnetic resonance imaging (MRI) is a crucial tool that supports understanding of neurodevelopment, yet it faces challenges due to the heterogeneity of data coming from different scanners and settings, as…

Magnetic resonance imaging (MRI) noninvasively provides critical information about how human brain structures develop across stages of life. Developmental scientists are particularly interested in the first few years of neurodevelopment.…

Image and Video Processing · Electrical Eng. & Systems 2021-05-31 Xuzhe Zhang , Xinzi He , Jia Guo , Nabil Ettehadi , Natalie Aw , David Semanek , Jonathan Posner , Andrew Laine , Yun Wang

Segmentation of magnetic resonance images (MRI) facilitates analysis of human brain development by delineating anatomical structures. However, in infants and young children, accurate segmentation is challenging due to development and…

Machine Learning · Computer Science 2026-04-01 Malte Hoffmann , Lilla Zöllei , Adrian V. Dalca

This paper presents an annotated dataset of brain MRI images designed to advance the field of brain symmetry study. Magnetic resonance imaging (MRI) has gained interest in analyzing brain symmetry in neonatal infants, and challenges remain…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Arnaud Gucciardi , Safouane El Ghazouali , Francesca Venturini , Vida Groznik , Umberto Michelucci

Modern deep learning models in computer vision require large datasets of real images, which are difficult to curate and pose privacy and legal concerns, limiting their commercial use. Recent works suggest synthetic data as an alternative,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Farnood Salehi , Vandit Sharma , Amirhossein Askari Farsangi , Tunç Ozan Aydın

Precise 3D segmentation of infant brain tissues is an essential step towards comprehensive volumetric studies and quantitative analysis of early brain developement. However, computing such segmentations is very challenging, especially for…

Computer Vision and Pattern Recognition · Computer Science 2017-12-20 Jose Dolz , Christian Desrosiers , Li Wang , Jing Yuan , Dinggang Shen , Ismail Ben Ayed
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