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Adapting models pre-trained on large-scale datasets is a proven way to reach strong performance quickly for down-stream tasks. However, the growth of state-of-the-art mod-els makes traditional full fine-tuning unsuitable and difficult,…
While model-based reconstruction methods have been successfully applied to flat-panel cone-beam CT (FP-CBCT) systems, typical implementations ignore both spatial correlations in the projection data as well as system blurs due to the…
Ultra high dose rate electron beams also known as FLASH radiotherapy is becoming of importance in several preclinial cancer treatment studies. However, due to the dose rate used during the irradiation sessions, no real time dose monitoring…
Background: Recently, the popularity of dual-layer flat-panel detector (DL-FPD) based dual-energy cone-beam CT (DE-CBCT) imaging has been increasing. However, the image quality of DE-CBCT remains constrained by the Compton scattered X-ray…
Pretrained Language Models (PLMs) have become the de facto starting point for fine-tuning on downstream tasks. However, as model sizes continue to increase, traditional fine-tuning of all the parameters becomes challenging. To address this,…
Vision foundation models (VFMs) have demonstrated remarkable capabilities in learning universal visual representations. However, adapting these models to downstream tasks conventionally requires parameter updates, with even…
Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning…
The major advantage of proton therapy over conventional radiotherapy is the dose deposition pattern, enabling precise coverage of the tumour volume while sparing nearby healthy tissues. However, accurate control of the proton beam range…
Active breath-hold techniques effectively mitigate respiratory motion but pose challenges for patients who are ineligible for the procedure. Conventional treatment planning relies on multiple energy layers, extending delivery time due to…
Multisequence Magnetic Resonance Imaging (MRI) provides a more reliable diagnosis in clinical applications through complementary information across sequences. However, in practice, the absence of certain MR sequences is a common problem…
Recently, shoot-through proton FLASH has been proposed where the highest energy is extracted from the cyclotron to maximize the dose rate (DR). Even though our proton pencil beam scanning system can deliver 250 MeV (the highest energy), it…
Proper X-ray radiation design (via dynamic fluence field modulation, FFM) allows to reduce effective radiation dose in computed tomography without compromising image quality. It takes into account patient anatomy, radiation sensitivity of…
Proteomic matrix-assisted laser desorption/ionisation (MALDI) linear time-of-flight (TOF) mass spectrometry (MS) may be used to produce protein profiles from biological samples with the aim of discovering biomarkers for disease. However,…
In this manuscript, we investigated the accuracy of the entire chain of phase space files generated by the TrueBeam VirtuaLinac system in clinical treatment plans. Good agreement was obtained between the MC simulation and the clinical…
The Free-Electron Laser (FEL) FLASH offers the worldwide still unique capability to study ultrafast processes with high-flux, high-repetition rate XUV and soft X-ray pulses. The vast majority of experiments at FLASH are of pump-probe type.…
The purpose of this study is to evaluate the clinical usefulness of modulated arc (mARC) treatment techniques. The mARC treatment plans of the non-small cell lung cancer (NSCLC) patients were performed in order to verify the clinical…
Deep learning models have emerged as a powerful tool for various medical applications. However, their success depends on large, high-quality datasets that are challenging to obtain due to privacy concerns and costly annotation. Generative…
Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…
Photonic computing has emerged as a promising substrate for accelerating the dense linear-algebra operations at the heart of AI, yet adoption for large Transformer models remains in its infancy. We identify two bottlenecks: (1) costly…
A new delivery option for cancer centers equipped with linear accelerators fitted with multi-leaf collimators (MLC) -- i.e. centers which can perform intensity modulated radiation therapy (IMRT) -- is rotational delivery. In rotational…