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In radiotherapy, the internal movement of organs between treatment sessions causes errors in the final radiation dose delivery. Motion models can be used to simulate motion patterns and assess anatomical robustness before delivery.…

Recent works have stressed the important role that random mutations have in the development of cancer phenotype. We challenge this current view by means of bioinformatic data analysis and computational modelling approaches. Not all the…

Cell Behavior · Quantitative Biology 2017-06-28 Gianluca Ascolani , Pietro Lió

This study presents new estimates for fractional derivatives without singular kernels defined by some specific functions. Based on obtained inequalities, we give a useful method to establish the global stability of steady states for…

Dynamical Systems · Mathematics 2022-04-21 Adnane Boukhouima , Houssine Zine , El Mehdi Lotfi , Marouane Mahrouf , Delfim F. M. Torres , Noura Yousfi

The sensitivity of trajectories over finite time intervals t to perturbations of the initial conditions can be associated with a finite-time Lyapunov exponent lambda, obtained from the elements M_{ij} of the stability matrix M. For globally…

Disordered Systems and Neural Networks · Physics 2007-05-23 H. Schomerus , M. Titov

Quantum chaos refers to signatures of classical chaos found in the quantum domain. Recently, it has become common to equate the exponential behavior of out-of-time order correlators (OTOCs) with quantum chaos. The quantum-classical…

We revisit the equilibrium one-dimensional $\phi^4$ model from the dynamical systems point of view. We find an infinite number of periodic orbits which are computationally stable. At the same time some of the orbits are found to exhibit…

Statistical Mechanics · Physics 2017-04-05 William Graham Hoover , Kenichiro Aoki

It has recently been discovered that the viscoelastic properties of cells are inherent markers reflecting the complex biological states, functions and malfunctions of the cells. Although the extraction of model parameters from the…

Biological Physics · Physics 2022-01-10 Anh Vo , Andrew Ekpenyong

Fractional stochastic volatility models have been widely used to capture the non-Markovian structure revealed from financial time series of realized volatility. On the other hand, empirical studies have identified scales in stock price…

Mathematical Finance · Quantitative Finance 2019-01-25 Jean-Pierre Fouque , Ruimeng Hu

Cancer cell mutations occur when cells undergo multiple cell divisions, and these mutations can be spontaneous or environmentally-induced. The mechanisms that promote and sustain these mutations are still not fully understood. This study…

Dynamical Systems · Mathematics 2021-10-27 Maher Alwuthaynani , Raluca Eftimie , Dumitru Trucu

We conduct a theoretical study of various solution methods for the adaptive fractionation problem. The two messages of this paper are: (i) dynamic programming (DP) is a useful framework for adaptive radiation therapy, particularly adaptive…

Medical Physics · Physics 2012-02-16 Jagdish Ramakrishnan , David Craft , Thomas Bortfeld , John N. Tsitsiklis

We study the effect of regime switches on finite size Lyapunov exponents (FSLEs) in determining the error growth rates and predictability of multiscale systems. We consider a dynamical system involving slow and fast regimes and switches…

Chaotic Dynamics · Physics 2014-09-03 Lewis Mitchell , Georg A. Gottwald

We analyse the spatial inhomogeneities ('spatial clustering') in the distribution of particles accelerated by a force that changes randomly in space and time. To quantify spatial clustering, the phase-space dynamics of the particles must be…

Statistical Mechanics · Physics 2021-02-04 J. Meibohm , K. Gustavsson , J. Bec , B. Mehlig

Cancer is a disease that takes millions of lives every year. Then, to propose treatments, avoid recurrence, and improve the patient's life quality, we need to analyze this disease from a biophysical perspective with a solid mathematical…

Quantitative Methods · Quantitative Biology 2024-07-09 Carlos M. Nieto , Oscar M. Pimentel , Fabio D. Lora-Clavijo

The equation with the time fractional substantial derivative and space fractional derivative describes the distribution of the functionals of the L\'evy flights; and the equation is derived as the macroscopic limit of the continuous time…

Numerical Analysis · Mathematics 2015-04-27 Minghua Chen , Weihua Deng

We present results of the numerical simulations and the scaling characteristics of one-dimensional random fluctuations with heavy tailed probability distribution functions. Assuming that the distribution function of the random fluctuations…

Statistical Mechanics · Physics 2017-08-16 Mohsen Ghasemi Nezhadhaghighi

In the theoretical research of Hepatitis B virus, mathematical models of its transmission mechanism have been thoroughly investigated, while the dynamics of the immune process in vivo have not. At present, nearly all the existing models are…

Chaotic Dynamics · Physics 2019-12-09 Xiaohe Yu , Fei Gao , Xingluan Wang , Jiangtao Zhang

The regular and chaotic behavior of modified Rayleigh-Duffing oscillator is studied. We consider in this paper the dynamics of Modified Rayleigh Duffing oscillator. The harmonic balance method are used to find the amplitudes of the…

Chaotic Dynamics · Physics 2014-03-28 C. H. Miwadinou , A. V. Monwanou , C. Ainamon , J. B. Chabi Orou

We discuss a dynamic procedure that makes the fractional derivatives emerge in the time asymptotic limit of non-Poisson processes. We find that two-state fluctuations, with an inverse power-law distribution of waiting times, finite first…

Statistical Mechanics · Physics 2009-11-10 Gerardo Aquino , Mauro Bologna , Paolo Grigolini , Bruce J. West

Using examples we test formulae previously conjectured to give the fractal information dimension of chaotic repellors and their stable and unstable manifolds in ``typical'' dynamical systems in terms of the Lyapunov exponents and the…

Chaotic Dynamics · Physics 2009-10-31 D. Sweet , E. Ott

Cancer is a complex disease and thus is complicated to model. However, simple models that describe the main processes involved in tumoral dynamics, e.g., competition and mutation, can give us clues about cancer behaviour, at least…

Dynamical Systems · Mathematics 2014-11-25 V. Castillo , J. Tomas Lazaro , J. Sardanyes