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Aging affects almost all aspects of an organism -- its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to…

Quantitative Methods · Quantitative Biology 2022-05-04 Katherine E. Overman , Daniel M. Choi , Kawai Leung , Joshua W. Shaevitz , Gordon J. Berman

Even the simplest of animals exhibit behavioral sequences with complex temporal dynamics. Prominent amongst the proposed organizing principles for these dynamics has been the idea of a hierarchy, wherein the movements an animal makes can be…

Biological Physics · Physics 2017-02-08 Gordon J. Berman , William Bialek , Joshua W. Shaevitz

Most animals possess the ability to actuate a vast diversity of movements, ostensibly constrained only by morphology and physics. In practice, however, a frequent assumption in behavioral science is that most of an animal's activities can…

Quantitative Methods · Quantitative Biology 2014-08-13 Gordon J. Berman , Daniel M. Choi , William Bialek , Joshua W. Shaevitz

In this paper we propose the Hatching-Box, a novel imaging and analysis system to automatically monitor and quantify the developmental behavior of Drosophila in standard rearing vials and during regular rearing routines, rendering explicit…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Julian Bigge , Maite Ogueta , Luis Garcia , Benjamin Risse

The explosion of data on animal behavior in more natural contexts highlights the fact that these behaviors exhibit correlations across many time scales. But there are major challenges in analyzing these data: records of behavior in single…

Neurons and Cognition · Quantitative Biology 2024-01-23 William Bialek , Joshua W. Shaevitz

Animal behavior unfolds across many timescales, from fast movement patterns to slow changes in internal states such as hunger, arousal, and circadian phase. These slow variables are rarely measured directly and must instead be inferred from…

Quantitative Methods · Quantitative Biology 2026-05-26 Rajpreet Kaur , Kanishk Jain , Gordon J. Berman

A fundamental goal in neuroscience is to understand the relationship between neural activity and behavior. For example, the ability to extract behavioral intentions from neural data, or neural decoding, is critical for developing effective…

Computer Vision and Pattern Recognition · Computer Science 2021-11-30 Semih Günel , Florian Aymanns , Sina Honari , Pavan Ramdya , Pascal Fua

Handedness in humans - better performance using either the left or right hand - is personally familiar, moderately heritable, and regulated by many genes, including those involved in general body symmetry. But behavioral handedness, i.e.…

Neurons and Cognition · Quantitative Biology 2016-07-13 Sean Buchanan , Jamey Kain , Benjamin de Bivort

Automated tracking of animal movement allows analyses that would not otherwise be possible by providing great quantities of data. The additional capability of tracking in realtime - with minimal latency - opens up the experimental…

Computer Vision and Pattern Recognition · Computer Science 2023-02-01 Andrew D. Straw , Kristin Branson , Titus R. Neumann , Michael H. Dickinson

Insects exhibit remarkable cognitive skills in the field and several cognitive abilities have been demonstrated in Drosophila in the laboratory. By devising an ethologically relevant experimental setup that also allows comparison of…

Neurons and Cognition · Quantitative Biology 2016-02-17 Shay Cohen , Yoav Benjamini , Ilan Golani

Studies of social and group behavior in interacting organisms require high-throughput analysis of the motion of a large number of individual subjects. Computer vision techniques offer solutions to specific tracking problems, and allow…

Quantitative Methods · Quantitative Biology 2015-06-12 Yi Deng , Philip Coen , Mingzhai Sun , Joshua W. Shaevitz

Computational models are critical to advance our understanding of how neural, biomechanical, and physical systems interact to orchestrate animal behaviors. Despite the availability of near-complete reconstructions of the Drosophila…

Neurons and Cognition · Quantitative Biology 2025-09-15 Pembe Gizem Özdil , Chuanfang Ning , Jasper S. Phelps , Sibo Wang-Chen , Guy Elisha , Alexander Blanke , Auke Ijspeert , Pavan Ramdya

Metabolism plays a crucial role in sleep regulation, yet its effects are challenging to track in real time. This study introduces a machine learning-based framework to analyze sleep patterns and identify how metabolic changes influence…

Quantitative Methods · Quantitative Biology 2025-03-18 Hao Huang , Kaijing Xu , Michael Lardelli

How predictable is the next move of an animal? Specifically, which factors govern the short- and long-term motion patterns and the overall dynamics of landbound, plant-eating animals and ruminants in particular? To answer this question, we…

Statistical Mechanics · Physics 2023-05-12 P. G. Meyer , A. G. Cherstvy , H. Seckler , R. Hering , N. Blaum , F. Jeltsch , R. Metzler

Due to the dynamic nature of biological systems, biological networks underlying temporal process such as the development of {\it Drosophila melanogaster} can exhibit significant topological changes to facilitate dynamic regulatory…

Molecular Networks · Quantitative Biology 2009-01-07 Amr Ahmed , Le Song , Eric P. Xing

Time series of heartbeat activity of humans can exhibit long-range correlations. In this paper we show that such kind of correlations can exist for the heartbeat activity of much simpler species like Drosophila melanogaster. By means of the…

Data Analysis, Statistics and Probability · Physics 2015-06-26 Nikolay K. Vitanov , Elka D. Yankulova

Although extensive behavioral changes often exist between closely related animal species, our understanding of the genetic basis underlying the evolution of behavior has remained limited. Here, we propose a new framework to study behavioral…

Populations and Evolution · Quantitative Biology 2020-07-21 Damián G. Hernández , Catalina Rivera , Jessica Cande , Baohua Zhou , David L. Stern , Gordon J. Berman

Everyday locomotion is a complex sensorimotor process that can unfold over multiple timescales, from long-term path planning to rapid, reactive adjustments. However, we lack an understanding of how factors such as environmental demands, or…

Machine Learning · Computer Science 2025-08-28 Wei-Chen Wang , Antoine De Comite , Alexandra Voloshina , Monica Daley , Nidhi Seethapathi

Aging and chronic conditions affect older adults' daily lives, making the early detection of developing health issues crucial. Weakness, which is common across many conditions, can subtly alter physical movements and daily activities.…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Chen Long-fei , Muhammad Ahmed Raza , Craig Innes , Subramanian Ramamoorthy , Robert B. Fisher

Our understanding of the neural basis of locomotor behavior can be informed by careful quantification of animal movement. Classical descriptions of legged locomotion have defined discrete locomotor gaits, characterized by distinct patterns…

Neurons and Cognition · Quantitative Biology 2022-03-02 Ana I. Gonçalves , Jacob A. Zavatone-Veth , Megan R. Carey , Damon A. Clark
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