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Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Computation and Language · Computer Science 2026-04-21 Xinyao Zhang , Nicole Sonne Heckmann , Manuela Del Castillo Suero , Francesco Paolo Speca , Maurizio Sessa

Large Language Models (LLMs) have shown promise in various domains, including healthcare, with significant potential to transform mental health applications by enabling scalable and accessible solutions. This study aims to provide a…

Artificial Intelligence · Computer Science 2025-11-25 Abdelrahman Hanafi , Mohammed Saad , Noureldin Zahran , Radwa J. Hanafy , Mohammed E. Fouda

Although supervised machine learning is popular for information extraction from clinical notes, creating large annotated datasets requires extensive domain expertise and is time-consuming. Meanwhile, large language models (LLMs) have…

Computation and Language · Computer Science 2024-01-26 Madhumita Sushil , Travis Zack , Divneet Mandair , Zhiwei Zheng , Ahmed Wali , Yan-Ning Yu , Yuwei Quan , Atul J. Butte

Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexplored. This study evaluated GPT-4's ability to interpret structured textual descriptions of…

Computation and Language · Computer Science 2025-07-03 Cindy Lie Tabuse , David Restepo , Carolina Gracitelli , Fernando Korn Malerbi , Caio Regatieri , Luis Filipe Nakayama

Large Language Models (LLMs) such as OpenAI's GPT-4 and Meta's LLaMA offer a promising approach for scalable personality assessment from open-ended language. However, inferring personality traits remains challenging, and earlier work often…

Computation and Language · Computer Science 2025-07-22 Jianfeng Zhu , Ruoming Jin , Karin G. Coifman

The use of large language models (LLMs) is expanding rapidly, and open-source versions are becoming available, offering users safer and more adaptable options. These models enable users to protect data privacy by eliminating the need to…

Machine Learning · Computer Science 2024-08-06 Hui Yin , Amir Aryani , Nakul Nambiar

The rapid advancement of Large Language Models (LLMs) presents a significant challenge to academic integrity within computing education. As educators seek reliable detection methods, this paper evaluates the capacity of three prominent LLMs…

Computers and Society · Computer Science 2025-12-30 Christopher Burger , Karmece Talley , Christina Trotter

Large Language Models (LLMs) are trained on massive amounts of data, enabling their application across diverse domains and tasks. Despite their remarkable performance, most LLMs are developed and evaluated primarily in English. Recently, a…

Computation and Language · Computer Science 2024-10-18 Krishno Dey , Prerona Tarannum , Md. Arid Hasan , Imran Razzak , Usman Naseem

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding across various domains, including healthcare and finance. For some tasks, LLMs achieve similar or better performance than trained human…

Artificial Intelligence · Computer Science 2023-10-13 Bruno Silva , Leonardo Nunes , Roberto Estevão , Vijay Aski , Ranveer Chandra

Large Language Models (LLMs), originally developed for natural language processing (NLP), have demonstrated the potential to generalize across modalities and domains. With their in-context learning (ICL) capabilities, LLMs can perform…

Artificial Intelligence · Computer Science 2025-08-26 Nikolaos Pavlidis , Vasilis Perifanis , Symeon Symeonidis , Pavlos S. Efraimidis

Large Language Models (LLMs) have shown promise in natural language processing tasks, with the potential to automate systematic reviews. This study evaluates the performance of three state-of-the-art LLMs in conducting systematic review…

Information Retrieval · Computer Science 2025-02-25 Xi Chen , Xue Zhang

Purpose: The performance of three different large language models (LLMS) (GPT-3.5, GPT-4, and PaLM2) in answering ophthalmology professional questions was evaluated and compared with that of three different professional populations (medical…

Computation and Language · Computer Science 2023-11-10 Jason Holmes , Shuyuan Ye , Yiwei Li , Shi-Nan Wu , Zhengliang Liu , Zihao Wu , Jinyu Hu , Huan Zhao , Xi Jiang , Wei Liu , Hong Wei , Jie Zou , Tianming Liu , Yi Shao

Large language models (LLMs) are playing an increasingly important role in science and engineering. For example, their ability to parse and understand human and computer languages makes them powerful interpreters and their use in…

Materials Science · Physics 2023-10-19 Juan C. Verduzco , Ethan Holbrook , Alejandro Strachan

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in…

Genomics · Quantitative Biology 2025-02-19 Wang Liang

Large Language Models (LLM) have recently been shown to perform well at various tasks from language understanding, reasoning, storytelling, and information search to theory of mind. In an extension of this work, we explore the ability of…

Computation and Language · Computer Science 2023-10-31 Nutchanon Yongsatianchot , Tobias Thejll-Madsen , Stacy Marsella

Large language models (LLMs) are currently at the forefront of intertwining AI systems with human communication and everyday life. Therefore, it is of great importance to evaluate their emerging abilities. In this study, we show that LLMs…

Computation and Language · Computer Science 2023-10-10 Thilo Hagendorff , Sarah Fabi , Michal Kosinski

Large Language Models (LLMs) have demonstrated remarkable performance across diverse natural language processing tasks, yet their ability to memorize structured knowledge remains underexplored. In this paper, we investigate the extent to…

Computation and Language · Computer Science 2025-04-02 Marco Bombieri , Paolo Fiorini , Simone Paolo Ponzetto , Marco Rospocher

While large language models (LLMs), such as GPT-3, appear to be robust and general, their reasoning ability is not at a level to compete with the best models trained for specific natural language reasoning problems. In this study, we…

Computation and Language · Computer Science 2023-07-18 Zhun Yang , Adam Ishay , Joohyung Lee

Genomic language models (gLMs) hold promise for generating novel, functional DNA sequences for synthetic biology. However, realizing this potential requires models to go beyond evolutionary plausibility and understand how DNA sequence…

Quantitative Methods · Quantitative Biology 2025-08-27 Shiyu Jiang , Xuyin Liu , Zitong Jerry Wang

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…