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We propose FlowReg, a deep learning-based framework for unsupervised image registration for neuroimaging applications. The system is composed of two architectures that are trained sequentially: FlowReg-A which affinely corrects for gross…

Computer Vision and Pattern Recognition · Computer Science 2021-09-02 Sergiu Mocanu , Alan R. Moody , April Khademi

Accurate delineation of tumor-adjacent functional brain regions is essential for planning function-preserving neurosurgery. Functional magnetic resonance imaging (fMRI) is increasingly used for presurgical counseling and planning. When…

Methodology · Statistics 2023-12-22 Yifei Hu , Xinge Jessie Jeng

Intra-fraction motion in radiotherapy is commonly modeled using deformable image registration (DIR). However, existing methods often struggle to balance speed and accuracy, limiting their applicability in clinical scenarios. This study…

Medical Physics · Physics 2024-02-09 Xia Li , Fabian Zhang , Muheng Li , Damien Weber , Antony Lomax , Joachim Buhmann , Ye Zhang

Image-guided surgery collocates patient-specific data with the physical environment to facilitate surgical decision making in real-time. Unfortunately, these guidance systems commonly become compromised by intraoperative soft-tissue…

Image and Video Processing · Electrical Eng. & Systems 2023-06-12 Morgan Ringel , Jon Heiselman , Winona Richey , Ingrid Meszoely , William Jarnagin , Michael Miga

We present Neural Shape Deformation Priors, a novel method for shape manipulation that predicts mesh deformations of non-rigid objects from user-provided handle movements. State-of-the-art methods cast this problem as an optimization task,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-02 Jiapeng Tang , Lev Markhasin , Bi Wang , Justus Thies , Matthias Nießner

Magnetic Resonance Imaging (MRI) typically recruits multiple sequences (defined here as "modalities"). As each modality is designed to offer different anatomical and functional clinical information, there are evident disparities in the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-09 Chengjia Wang , Guang Yang , Giorgos Papanastasiou

Objective: In medical imaging, it is often crucial to accurately assess and correct movement during image-guided therapy. Deformable image registration (DIR) consists in estimating the required spatial transformation to align a moving image…

Computer Vision and Pattern Recognition · Computer Science 2024-05-22 Eloïse Inacio , Luc Lafitte , Laurent Facq , Clair Poignard , Baudouin Denis de Senneville

Objective: Deformable brain MR image registration is challenging due to large inter-subject anatomical variation. For example, the highly complex cortical folding pattern makes it hard to accurately align corresponding cortical structures…

Computer Vision and Pattern Recognition · Computer Science 2019-02-07 Dongming Wei , Zhengwang Wu , Gang Li , Xiaohuan Cao , Dinggang Shen , Qian Wang

Established surgical navigation systems for pedicle screw placement have been proven to be accurate, but still reveal limitations in registration or surgical guidance. Registration of preoperative data to the intraoperative anatomy remains…

Deformable image registration between Computed Tomography (CT) images and Magnetic Resonance (MR) imaging is essential for many image-guided therapies. In this paper, we propose a novel translation-based unsupervised deformable image…

Image and Video Processing · Electrical Eng. & Systems 2020-09-22 Zhe Xu , Jie Luo , Jiangpeng Yan , Ritvik Pulya , Xiu Li , William Wells , Jayender Jagadeesan

The surgical environment imposes unique challenges to the intraoperative registration of organ shapes to their preoperatively-imaged geometry. Biomechanical model-based registration remains popular, while deep learning solutions remain…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Dingrong Wang , Soheil Azadvar , Jon Heiselman , Xiajun Jiang , Michael Miga , Linwei Wang

In modern medical diagnostics, magnetic resonance imaging (MRI) is an important technique that provides detailed insights into anatomical structures. In this paper, we present a comprehensive methodology focusing on streamlining the…

Image and Video Processing · Electrical Eng. & Systems 2024-04-25 Siddharth Jha , Zichen Gui , Benjamin Delbos , Richard Moreau , Arnaud Leleve , Irene Cheng

Unsupervised learning strategy is widely adopted by the deformable registration models due to the lack of ground truth of deformation fields. These models typically depend on the intensity-based similarity loss to obtain the learning…

Image and Video Processing · Electrical Eng. & Systems 2021-12-21 Luyi Han , Haoran Dou , Yunzhi Huang , Pew-Thian Yap

Deformable medical image registration is a fundamental task in medical image analysis. While deep learning-based methods have demonstrated superior accuracy and computational efficiency compared to traditional techniques, they often…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Ahsan Raza Siyal , Markus Haltmeier , Ruth Steiger , Malik Galijasevic , Elke Ruth Gizewski , Astrid Ellen Grams

Registration of pre-operative and follow-up brain MRI scans is challenging due to the large variation of tissue appearance and missing correspondences in tumour recurrence regions caused by tumour mass effect. Although recent deep…

Image and Video Processing · Electrical Eng. & Systems 2022-11-15 Tony C. W. Mok , Albert C. S. Chung

Effective representation of Regions of Interest (ROI) and independent alignment of these ROIs can significantly enhance the performance of deformable medical image registration (DMIR). However, current learning-based DMIR methods have…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Xinke Ma , Yongsheng Pan , Qingjie Zeng , Mengkang Lu , Bolysbek Murat Yerzhanuly , Bazargul Matkerim , Yong Xia

Deep learning (DL) has led to significant improvements in medical image synthesis, enabling advanced image-to-image translation to generate synthetic images. However, DL methods face challenges such as domain shift and high demands for…

Image and Video Processing · Electrical Eng. & Systems 2024-02-20 Savannah P. Hays , Lianrui Zuo , Yihao Liu , Anqi Feng , Jiachen Zhuo , Jerry L. Prince , Aaron Carass

Most of the deep learning based medical image registration algorithms focus on brain image registration tasks.Compared with brain registration, the chest CT registration has larger deformation, more complex background and region over-lap.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Cheng Wang , Qiyu Gao , Fandong Zhang , Shu Zhang , Yizhou Yu

Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function that…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Malte Hoffmann , Andrew Hoopes , Douglas N. Greve , Bruce Fischl , Adrian V. Dalca

Purpose: In surgical navigation, pre-operative organ models are presented to surgeons during the intervention to help them in efficiently finding their target. In the case of soft tissue, these models need to be deformed and adapted to the…

Graphics · Computer Science 2019-04-02 Micha Pfeiffer , Carina Riediger , Jürgen Weitz , Stefanie Speidel