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We present two deep generative models based on Variational Autoencoders to improve the accuracy of drug response prediction. Our models, Perturbation Variational Autoencoder and its semi-supervised extension, Drug Response Variational…

Machine Learning · Statistics 2017-07-07 Ladislav Rampasek , Daniel Hidru , Petr Smirnov , Benjamin Haibe-Kains , Anna Goldenberg

The variational autoencoder (VAE; Kingma, Welling (2014)) is a recently proposed generative model pairing a top-down generative network with a bottom-up recognition network which approximates posterior inference. It typically makes strong…

Machine Learning · Computer Science 2016-11-08 Yuri Burda , Roger Grosse , Ruslan Salakhutdinov

A new form of the variational autoencoder (VAE) is proposed, based on the symmetric Kullback-Leibler divergence. It is demonstrated that learning of the resulting symmetric VAE (sVAE) has close connections to previously developed…

Machine Learning · Statistics 2017-10-23 Liqun Chen , Shuyang Dai , Yunchen Pu , Chunyuan Li , Qinliang Su , Lawrence Carin

Technological advancements have led to the rise of wearable devices with sensors that continuously monitor user activities, generating vast amounts of unlabeled data. This data is challenging to interpret, and manual annotation is…

Machine Learning · Computer Science 2025-05-09 Soham Khisa , Avijoy Chakma

Density estimation, compression and data generation are crucial tasks in artificial intelligence. Variational Auto-Encoders (VAEs) constitute a single framework to achieve these goals. Here, we present a novel class of generative models,…

Machine Learning · Statistics 2021-07-07 Ioannis Gatopoulos , Jakub M. Tomczak

Large vision-language models (LVLMs) frequently suffer from Object Hallucination (OH), wherein they generate descriptions containing objects that are not actually present in the input image. This phenomenon is particularly problematic in…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Yanbin Huang , Yisen Li , Guiyao Tie , Xiaoye Qu , Pan Zhou , Hongfei Wang , Zhaofan Zou , Hao Sun , Xuelong Li

Variational Autoencoders (VAEs) have played a key role in scaling up diffusion-based generative models, as in Stable Diffusion, yet questions regarding their robustness remain largely underexplored. Although adversarial training has been an…

Machine Learning · Computer Science 2025-04-25 Hyomin Lee , Minseon Kim , Sangwon Jang , Jongheon Jeong , Sung Ju Hwang

A variational autoencoder (VAE) is a probabilistic machine learning framework for posterior inference that projects an input set of high-dimensional data to a lower-dimensional, latent space. The latent space learned with a VAE offers…

Machine Learning · Computer Science 2022-11-16 Rafael Pastrana

Disentangled visual representations have largely been studied with generative models such as Variational AutoEncoders (VAEs). While prior work has focused on generative methods for disentangled representation learning, these approaches do…

Computer Vision and Pattern Recognition · Computer Science 2021-08-17 Andrea Burns , Aaron Sarna , Dilip Krishnan , Aaron Maschinot

Variational autoencoders are among the most popular methods for distilling low-dimensional structure from high-dimensional data, making them increasingly valuable as tools for data exploration and scientific discovery. However, unlike…

Machine Learning · Computer Science 2022-01-17 Miles Martinez , John Pearson

Conditional Variational Auto Encoders (VAE) are gathering significant attention as an Explainable Artificial Intelligence (XAI) tool. The codes in the latent space provide a theoretically sound way to produce counterfactuals, i.e.…

Machine Learning · Computer Science 2021-02-02 Nicolas Vercheval , Aleksandra Pizurica

The variational autoencoder (VAE) is a popular model for density estimation and representation learning. Canonically, the variational principle suggests to prefer an expressive inference model so that the variational approximation is…

Machine Learning · Statistics 2019-01-10 Rui Shu , Hung H. Bui , Shengjia Zhao , Mykel J. Kochenderfer , Stefano Ermon

Learning rich data representations from unlabeled data is a key challenge towards applying deep learning algorithms in downstream tasks. Several variants of variational autoencoders (VAEs) have been proposed to learn compact data…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Pan Xiao , Peijie Qiu , Sungmin Ha , Abdalla Bani , Shuang Zhou , Aristeidis Sotiras

The variational autoencoder (VAE) is a generative model with continuous latent variables where a pair of probabilistic encoder (bottom-up) and decoder (top-down) is jointly learned by stochastic gradient variational Bayes. We first…

Machine Learning · Statistics 2016-04-19 Suwon Suh , Seungjin Choi

One noted issue of vector-quantized variational autoencoder (VQ-VAE) is that the learned discrete representation uses only a fraction of the full capacity of the codebook, also known as codebook collapse. We hypothesize that the training…

Recently, introspective models like IntroVAE and S-IntroVAE have excelled in image generation and reconstruction tasks. The principal characteristic of introspective models is the adversarial learning of VAE, where the encoder attempts to…

Image and Video Processing · Electrical Eng. & Systems 2022-11-01 Changjie Lu , Shen Zheng , Zirui Wang , Omar Dib , Gaurav Gupta

Variational Autoencoder (VAE) aims to compress pixel data into low-dimensional latent space, playing an important role in OpenAI's Sora and other latent video diffusion generation models. While most of existing video VAEs inflate a…

Computer Vision and Pattern Recognition · Computer Science 2024-11-12 Pingyu Wu , Kai Zhu , Yu Liu , Liming Zhao , Wei Zhai , Yang Cao , Zheng-Jun Zha

Variational autoencoders (VAEs) often suffer from posterior collapse, which is a phenomenon in which the learned latent space becomes uninformative. This is often related to the hyperparameter resembling the data variance. It can be shown…

Machine Learning · Computer Science 2022-08-23 Yuhta Takida , Wei-Hsiang Liao , Chieh-Hsin Lai , Toshimitsu Uesaka , Shusuke Takahashi , Yuki Mitsufuji

Variational autoencoder (VAE) is a very successful generative model whose key element is the so called amortized inference network, which can perform test time inference using a single feed forward pass. Unfortunately, this comes at the…

Machine Learning · Computer Science 2021-02-08 Minyoung Kim , Vladimir Pavlovic

Variational autoencoders (VAEs) frequently suffer from posterior collapse, where the latent variables become uninformative as the approximate posterior degenerates to the prior. While recent work has characterized collapse as a phase…

Machine Learning · Computer Science 2026-05-19 Zegu Zhang , Jian Zhang
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