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Identifying unique parameters for mathematical models describing biological data can be challenging and often impossible. Parameter identifiability for partial differential equations models in cell biology is especially difficult given that…

Quantitative Methods · Quantitative Biology 2024-03-05 Maria-Veronica Ciocanel , Lee Ding , Lucas Mastromatteo , Sarah Reichheld , Sarah Cabral , Kimberly Mowry , Bjorn Sandstede

Many recent works have reconstructed distinctive 3D face shapes by aggregating shape parameters of the same identity and separating those of different people based on parametric models (e.g., 3D morphable models (3DMMs)). However, despite…

Computer Vision and Pattern Recognition · Computer Science 2021-12-28 Diqiong Jiang , Yiwei Jin , Fanglue Zhang , Yukun Yai , Risheng Deng , Ruofeng Tong , Min Tang

This work applies concepts of artificial neural networks to identify the parameters of a mathematical model based on phase fields for damage and fracture. Damage mechanics is the part of the continuum mechanics that models the effects of…

Materials Science · Physics 2021-07-21 Carlos J. G. Rojas , Marco L. Bitterncourt , José L. Boldrini

The system identification problem is to estimate dynamical parameters from the output data, obtained by performing measurements on the output fields. We investigate system identification for quantum linear systems. Our main objectives are…

Quantum Physics · Physics 2017-12-25 Matthew Levitt , Mădălin Guţă , Theodore Kypraios

Identification of the parameters of stable linear dynamical systems is a well-studied problem in the literature, both in the low and high-dimensional settings. However, there are hardly any results for the unstable case, especially…

Systems and Control · Computer Science 2018-06-06 Mohamad Kazem Shirani Faradonbeh , Ambuj Tewari , George Michailidis

An important problem in biological modeling is choosing the right model. Given experimental data, one is supposed to find the best mathematical representation to describe the real-world phenomena. However, there may not be a unique model…

Dynamical Systems · Mathematics 2024-07-03 Cashous Bortner , Nicolette Meshkat

A novel framework is introduced to formalize identifiability in well-specified but ill-posed linear regression models. The framework is distribution-free and accommodates highly correlated features that may or may not relate to the…

Statistics Theory · Mathematics 2026-03-05 Gianluca Finocchio , Tatyana Krivobokova

We present a new method for parameter identification of ODE system descriptions based on data measurements. Our method works by splitting the system into a number of subsystems and working on each of them separately, thereby being easily…

Computational Engineering, Finance, and Science · Computer Science 2012-08-21 Anastasis Georgoulas , Allan Clark , Andrea Ocone , Stephen Gilmore , Guido Sanguinetti

Orthogonally invariant functions of symmetric matrices often inherit properties from their diagonal restrictions: von Neumann's theorem on matrix norms is an early example. We discuss the example of "identifiability", a common property of…

Optimization and Control · Mathematics 2013-04-15 Aris Daniilidis , Dmitriy Drusvyatskiy , Adrian S. Lewis

To be fully useful for public health practice, models for epidemic response must be able to do more than predict -- it is also important to incorporate the mechanisms underlying transmission dynamics to enable policymakers and practitioners…

Quantitative Methods · Quantitative Biology 2025-05-26 Jiale Tan , Marisa C. Eisenberg

The dynamics of systems biological processes are usually modeled by a system of ordinary differential equations (ODEs) with many unknown parameters that need to be inferred from noisy and sparse measurements. Here, we introduce…

Quantitative Methods · Quantitative Biology 2022-02-04 Mitchell Daneker , Zhen Zhang , George Em Karniadakis , Lu Lu

Identifiability conditions for single or multiple modules in a dynamic network specify under which conditions the considered modules can be uniquely recovered from the second-order statistical properties of the measured signals. Conditions…

Systems and Control · Electrical Eng. & Systems 2021-10-28 Shengling Shi , Xiaodong Cheng , Paul M. J. Van den Hof

Many models in mathematical epidemiology are developed with the aim to provide a framework for parameter estimation and then prediction. It is well-known that parameters are not always uniquely identifiable. In this paper we consider…

Dynamical Systems · Mathematics 2022-08-17 István Zoltán Kiss , Péter L. Simon

Identifying parameters in a system of nonlinear, ordinary differential equations is vital for designing a robust controller. However, if the system is stochastic in its nature or if only noisy measurements are available, standard…

Systems and Control · Electrical Eng. & Systems 2022-10-10 Tobias Nagel , Marco F. Huber

Parametric models abstract part of the specification of dynamical models by integral parameters. They are for example used in computational systems biology, notably with parametric regulatory networks, which specify the global architecture…

Logic in Computer Science · Computer Science 2018-11-30 Stefan Haar , Juraj Kolčák , Loïc Paulevé

We consider the identifiability and stable numerical estimation of multiple parameters in a Cahn-Hilliard model for phase separation. Spatially resolved measurements of the phase fraction are assumed to be accessible, with which the…

Numerical Analysis · Mathematics 2023-05-03 Aaron Brunk , Herbert Egger , Oliver Habrich

In this paper we propose a solution to the problem of parameter estimation of nonlinearly parameterized regressions--continuous or discrete time--and apply it for system identification and adaptive control. We restrict our attention to…

Optimization and Control · Mathematics 2019-10-18 Romeo Ortega , Vladislav Gromov , Emmanuel Nuño , Anton Pyrkin , Jose Guadalupe Romero

This paper provides a general identification approach for a wide range of nonlinear panel data models, including binary choice, ordered response, and other types of limited dependent variable models. Our approach accommodates dynamic models…

Econometrics · Economics 2026-01-09 Wayne Yuan Gao , Rui Wang

Learning a dynamical system from input/output data is a fundamental task in the control design pipeline. In the partially observed setting there are two components to identification: parameter estimation to learn the Markov parameters, and…

Optimization and Control · Mathematics 2021-09-08 Han Wang , James Anderson

The identification of a linear system model from data has wide applications in control theory. The existing work that provides finite sample guarantees for linear system identification typically uses data from a single long system…

Machine Learning · Statistics 2025-05-09 Lei Xin , Baike She , Qi Dou , George Chiu , Shreyas Sundaram