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Photoacoustic tomography (PAT) is a rapidly-evolving medical imaging modality that combines optical absorption contrast with ultrasound imaging depth. One challenge in PAT is image reconstruction with inadequate acoustic signals due to…

In this paper, we provide a novel method for the estimation of unknown parameters of the Gaussian Mixture Model (GMM) in Positron Emission Tomography (PET). A vast majority of PET imaging methods are based on reconstruction model that is…

Signal Processing · Electrical Eng. & Systems 2023-06-30 Tomislav Matulić , Damir Seršić

During orthopaedic surgery, the inserting of metallic implants or screws are often performed under mobile C-arm systems. Due to the high attenuation of metals, severe metal artifacts occur in 3D reconstructions, which degrade the image…

Image and Video Processing · Electrical Eng. & Systems 2022-09-21 Siyuan Mei , Fuxin Fan , Andreas Maier

This paper explores the use of score-based diffusion models for Bayesian image reconstruction. Diffusion models are an efficient tool for generative modeling. Diffusion models can also be used for solving image reconstruction problems. We…

Image and Video Processing · Electrical Eng. & Systems 2025-10-06 Michael T. McCann , Hyungjin Chung , Jong Chul Ye , Marc L. Klasky

Score-based diffusion models have significantly advanced generative deep learning for image processing. Measurement conditioned models have also been applied to inverse problems such as CT reconstruction. However, the conventional approach,…

Medical Physics · Physics 2025-02-24 Matthew Tivnan , Dufan Wu , Quanzheng Li

Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches…

Medical Physics · Physics 2026-03-18 George Webber , Alexander Hammers , Andrew P King , Andrew J Reader

Fluorodeoxyglucose (FDG) PET to evaluate patients with epilepsy is one of the most common applications for simultaneous PET/MRI, given the need to image both brain structure and metabolism, but is suboptimal due to the radiation dose in…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Jiaqi Wu , Jiahong Ouyang , Farshad Moradi , Mohammad Mehdi Khalighi , Greg Zaharchuk

This paper reviewed the machine learning-based studies for quantitative positron emission tomography (PET). Specifically, we summarized the recent developments of machine learning-based methods in PET attenuation correction and low-count…

Image and Video Processing · Electrical Eng. & Systems 2020-01-22 Tonghe Wang , Yang Lei , Yabo Fu , Walter J. Curran , Tian Liu , Xiaofeng Yang

Positron emission tomography (PET) reconstruction is a critical challenge in molecular imaging, often hampered by noise amplification, structural blurring, and detail loss due to sparse sampling and the ill-posed nature of inverse problems.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Mengxiao Geng , Zijie Chen , Ran Hong , Bingxuan Li , Qiegen Liu

Uncompressed clinical data from modern positron emission tomography (PET) scanners are very large, exceeding 350 million data points (projection bins). The last decades have seen tremendous advancements in mathematical imaging tools many of…

Medical Physics · Physics 2020-01-08 Matthias J. Ehrhardt , Pawel Markiewicz , Carola-Bibiane Schönlieb

In this paper, we review physics- and data-driven reconstruction techniques for simultaneous positron emission tomography (PET) / magnetic resonance imaging (MRI) systems, which have significant advantages for clinical imaging of cancer,…

Image and Video Processing · Electrical Eng. & Systems 2022-06-15 Abhejit Rajagopal , Andrew P. Leynes , Nicholas Dwork , Jessica E. Scholey , Thomas A. Hope , Peder E. Z. Larson

Positron emission tomography (PET) is the most sensitive molecular imaging modality routinely applied in our modern healthcare. High radioactivity caused by the injected tracer dose is a major concern in PET imaging and limits its clinical…

Image and Video Processing · Electrical Eng. & Systems 2023-04-04 Yuxin Xue , Yige Peng , Lei Bi , Dagan Feng , Jinman Kim

Image reconstruction for positron emission tomography (PET) is challenging because of the ill-conditioned tomographic problem and low counting statistics. Kernel methods address this challenge by using kernel representation to incorporate…

Image and Video Processing · Electrical Eng. & Systems 2022-05-26 Siqi Li , Guobao Wang

Positron emission tomography (PET) image synthesis plays an important role, which can be used to boost the training data for computer aided diagnosis systems. However, existing image synthesis methods have problems in synthesizing the low…

Computer Vision and Pattern Recognition · Computer Science 2017-08-01 Lei Bi , Jinman Kim , Ashnil Kumar , Dagan Feng , Michael Fulham

Neurological Positron Emission Tomography (PET) is a critical imaging modality for diagnosing and studying neurodegenerative diseases like Alzheimer's disease. However, the inherent low spatial resolution of PET images poses significant…

Medical Physics · Physics 2025-02-24 Matthew Tivnan , Quanzheng Li

Positron Emission Tomography and Magnetic Resonance Imaging (PET-MRI) systems can obtain functional and anatomical scans. PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Taofeng Xie , Zhuo-Xu Cui , Chen Luo , Huayu Wang , Congcong Liu , Yuanzhi Zhang , Xuemei Wang , Yanjie Zhu , Guoqing Chen , Dong Liang , Qiyu Jin , Yihang Zhou , Haifeng Wang

Over the past years, pseudo-healthy reconstruction for unsupervised anomaly detection has gained in popularity. This approach has the great advantage of not requiring tedious pixel-wise data annotation and offers possibility to generalize…

Image and Video Processing · Electrical Eng. & Systems 2024-01-30 Ravi Hassanaly , Camille Brianceau , Maëlys Solal , Olivier Colliot , Ninon Burgos

The integration of multimodal medical imaging can provide complementary and comprehensive information for the diagnosis of Alzheimer's disease (AD). However, in clinical practice, since positron emission tomography (PET) is often missing,…

Computational Engineering, Finance, and Science · Computer Science 2024-12-03 Fuyou Mao , Lixin Lin , Ming Jiang , Dong Dai , Chao Yang , Hao Zhang , Yan Tang

Recent advances in generative artificial intelligence have had a significant impact on diverse domains spanning computer vision, natural language processing, and drug discovery. This work extends the reach of generative models into physical…

Machine Learning · Computer Science 2024-10-22 Christian Jacobsen , Yilin Zhuang , Karthik Duraisamy

Positron Emission Tomography (PET) is a functional imaging modality that enables the visualization of biochemical and physiological processes across various tissues. Recently, deep learning (DL)-based methods have demonstrated significant…

Image and Video Processing · Electrical Eng. & Systems 2026-01-16 Yiran Sun , Osama Mawlawi