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Denoising low-dose computed tomography (CT) images is a critical task in medical image computing. Supervised deep learning-based approaches have made significant advancements in this area in recent years. However, these methods typically…

Image and Video Processing · Electrical Eng. & Systems 2023-07-17 Xuan Liu , Yaoqin Xie , Jun Cheng , Songhui Diao , Shan Tan , Xiaokun Liang

Due to various physical degradation factors and limited counts received, PET image quality needs further improvements. The denoising diffusion probabilistic models (DDPM) are distribution learning-based models, which try to transform a…

Image and Video Processing · Electrical Eng. & Systems 2022-09-15 Kuang Gong , Keith A. Johnson , Georges El Fakhri , Quanzheng Li , Tinsu Pan

Fluorodeoxyglucose (FDG) PET to evaluate patients with epilepsy is one of the most common applications for simultaneous PET/MRI, given the need to image both brain structure and metabolism, but is suboptimal due to the radiation dose in…

Image and Video Processing · Electrical Eng. & Systems 2025-07-01 Jiaqi Wu , Jiahong Ouyang , Farshad Moradi , Mohammad Mehdi Khalighi , Greg Zaharchuk

Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a…

Medical Physics · Physics 2025-08-28 George Webber , Alexander Hammers , Andrew P. King , Andrew J. Reader

Magnetic resonance imaging (MRI) and positron emission tomography (PET) are increasingly used in multimodal analysis of neurodegenerative disorders. While MRI is broadly utilized in clinical settings, PET is less accessible. Many studies…

Image and Video Processing · Electrical Eng. & Systems 2024-11-13 Minhui Yu , Mengqi Wu , Ling Yue , Andrea Bozoki , Mingxia Liu

Gating is commonly used in PET imaging to reduce respiratory motion blurring and facilitate more sophisticated motion correction methods. In the applications of low dose PET, however, reducing injection dose causes increased noise and…

Image and Video Processing · Electrical Eng. & Systems 2020-09-16 Bo Zhou , Yu-Jung Tsai , Chi Liu

The degradation of the acquired signal by Poisson noise is a common problem for various imaging applications, such as medical imaging, night vision and microscopy. Up to now, many state-of-the-art Poisson denoising techniques mainly…

Computer Vision and Pattern Recognition · Computer Science 2015-10-13 Wensen Feng , Yunjin Chen

A standard dose of radioactive tracer must be delivered into the patients body to obtain high-quality Positron Emission Tomography (PET) images for diagnostic purposes, which raises the risk of radiation harm. A reduced tracer dose, on the…

Dynamic positron emission tomography (PET) images can reveal the distribution of tracers in the organism and the dynamic processes involved in biochemical reactions, and it is widely used in clinical practice. Despite the high effectiveness…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Jie Sun , Junyan Zhang , Qian Xia , Chuanfu Sun , Yumei Chen , Yunjie Yang , Huafeng Liu , Wentao Zhu , Qiegen Liu

Low-dose Positron Emission Tomography (PET) imaging reduces patient radiation exposure but suffers from increased noise that degrades image quality and diagnostic reliability. Although diffusion models have demonstrated strong denoising…

Positron emission tomography (PET) is an important functional medical imaging technique often used in the evaluation of certain brain disorders, whose reconstruction problem is ill-posed. The vast majority of reconstruction methods in PET…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Tin Vlašić , Tomislav Matulić , Damir Seršić

Although supervised convolutional neural networks (CNNs) often outperform conventional alternatives for denoising positron emission tomography (PET) images, they require many low- and high-quality reference PET image pairs. Herein, we…

Medical Physics · Physics 2021-09-29 Yuya Onishi , Fumio Hashimoto , Kibo Ote , Hiroyuki Ohba , Ryosuke Ota , Etsuji Yoshikawa , Yasuomi Ouchi

Positron Emission Tomography (PET) imaging requires accurate attenuation correction (AC) to account for photon loss due to tissue density variations. In PET/MR systems, computed tomography (CT), which offers a straightforward estimation of…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Weijie Chen , James Wang , Alan McMillan

As a sensitive functional imaging technique, positron emission tomography (PET) plays a critical role in early disease diagnosis. However, obtaining a high-quality PET image requires injecting a sufficient dose (standard dose) of…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Caiwen Jiang , Mianxin Liu , Kaicong Sun , Dinggang Shen

Increasing use of CT in modern medical practice has raised concerns over associated radiation dose. Reduction of radiation dose associated with CT can increase noise and artifacts, which can adversely affect diagnostic confidence. Denoising…

Computer Vision and Pattern Recognition · Computer Science 2017-02-24 Qingsong Yang , Pingkun Yan , Mannudeep K. Kalra , Ge Wang

Objective Positron emission tomography (PET) allows imaging of patho-physiological information as a form of rate constants from a dynamic image. The rate constant image(s) may be affected from noise on the dynamic image. We introduced an…

Medical Physics · Physics 2023-08-10 Nobuyuki Kudomi , Yukito Maeda

The generalization of deep learning-based low-dose computed tomography (CT) reconstruction models to doses unseen in the training data is important and remains challenging. Previous efforts heavily rely on paired data to improve the…

Image and Video Processing · Electrical Eng. & Systems 2025-06-30 Qi Gao , Zhihao Chen , Dong Zeng , Junping Zhang , Jianhua Ma , Hongming Shan

Low-dose Computed Tomography (LDCT) reconstruction is an important task in medical image analysis. Recent years have seen many deep learning based methods, proved to be effective in this area. However, these methods mostly follow a…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Runyi Li

The foreseen CaLIPSO Positron Emission Tomography (PET) scanner is expected to yield simultaneously a fine image resolution, about 1 mm$^3$, and a high contrast. In this paper we present results of simulations for the full CaLIPSO PET…

Positron Emission Tomography (PET) scanners are usually designed with the goal to obtain the best compromise between sensitivity, resolution, field-of-view size, and cost. Therefore, it is difficult to improve the resolution of a PET…

Medical Physics · Physics 2023-07-18 Pablo Galve , Alejandro Lopez-Montes , Jose M Udias , Stephen C Moore , Joaquin L Herraiz