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The problem of estimating the slope parameter in regression between two spatial processes under confounding by an unmeasured spatial process has received widespread attention in the recent statistical literature. Yet, a fundamental question…

Statistics Theory · Mathematics 2026-03-04 Abhirup Datta , Michael L. Stein

The estimation of regression parameters in spatially referenced data plays a crucial role across various scientific domains. A common approach involves employing an additive regression model to capture the relationship between observations…

Statistics Theory · Mathematics 2024-03-29 David Bolin , Jonas Wallin

Estimating effects of spatially structured exposures is complicated by unmeasured spatial confounders, which undermine identifiability in spatial linear regression models unless structural assumptions are imposed. We develop a general…

Methodology · Statistics 2025-12-30 Anik Burman , Elizabeth L. Ogburn , Abhirup Datta

Over the past few decades, addressing "spatial confounding" has become a major topic in spatial statistics. However, the literature has provided conflicting definitions, and many proposed solutions are tied to specific analysis models and…

Methodology · Statistics 2024-10-14 Brian Gilbert , Abhirup Datta , Joan A. Casey , Elizabeth L. Ogburn

Non-gaussian spatial data are very common in many disciplines. For instance, count data are common in disease mapping, and binary data are common in ecology. When fitting spatial regressions for such data, one needs to account for…

Methodology · Statistics 2010-12-01 John Hughes , Murali Haran

A key challenge in environmental health research is unmeasured spatial confounding, driven by unobserved spatially structured variables that influence both treatment and outcome. A common approach is to fit a spatial regression that models…

Methodology · Statistics 2025-12-23 Sophie M. Woodward , Francesca Dominici , Jose R. Zubizarreta

The issue of spatial confounding between the spatial random effect and the fixed effects in regression analyses has been identified as a concern in the statistical literature. Multiple authors have offered perspectives and potential…

Methodology · Statistics 2023-01-18 Kori Khan , Catherine A. Calder

In linear models, the generalized least squares (GLS) estimator is applicable when the structure of the error dependence is known. When it is unknown, such structure must be approximated and estimated in a manner that may lead to…

Statistics Theory · Mathematics 2019-02-12 Hien D Nguyen

Consider a regression model with infinitely many parameters and time series errors. We are interested in choosing weights for averaging across generalized least squares (GLS) estimators obtained from a set of approximating models. However,…

Statistics Theory · Mathematics 2016-10-05 Tzu-Chang F. Cheng , Ching-Kang Ing , Shu-Hui Yu

Unmeasured spatial confounding complicates exposure effect estimation in environmental health studies. This problem is exacerbated in studies with multiple health outcomes and environmental exposure variables, as the source and magnitude of…

Spatial models are used in a variety research areas, such as environmental sciences, epidemiology, or physics. A common phenomenon in many spatial regression models is spatial confounding. This phenomenon takes place when spatially indexed…

Methodology · Statistics 2021-06-08 Isa Marques , Thomas Kneib , Nadja Klein

Analysis of geospatial data has traditionally been model-based, with a mean model, customarily specified as a linear regression on the covariates, and a covariance model, encoding the spatial dependence. We relax the strong assumption of…

Machine Learning · Statistics 2024-05-28 Wentao Zhan , Abhirup Datta

Residuals in regression models are often spatially correlated. Prominent examples include studies in environmental epidemiology to understand the chronic health effects of pollutants. I consider the effects of residual spatial structure on…

Methodology · Statistics 2010-11-05 Christopher J. Paciorek

This paper proposes a new approach to address the problem of unmeasured confounding in spatial designs. Spatial confounding occurs when some confounding variables are unobserved and not included in the model, leading to distorted…

Methodology · Statistics 2025-03-05 Carlo Zaccardi , Pasquale Valentini , Luigi Ippoliti , Alexandra M. Schmidt

The generalized least square (GLS) is one of the most basic tools in regression analyses. A major issue in implementing the GLS is estimation of the conditional variance function of the error term, which typically requires a restrictive…

Econometrics · Economics 2024-01-24 Yoichi Arai , Taisuke Otsu , Mengshan Xu

Latent confounders---unobserved variables that influence both treatment and outcome---can bias estimates of causal effects. In some cases, these confounders are shared across observations, e.g. all students taking a course are influenced by…

Methodology · Statistics 2020-07-15 Sam Witty , Kenta Takatsu , David Jensen , Vikash Mansinghka

Public health data are often spatially dependent, but standard spatial regression methods can suffer from bias and invalid inference when the independent variable is associated with spatially-correlated residuals. This could occur if, for…

Methodology · Statistics 2025-04-10 Nate Wiecha , Jane A. Hoppin , Brian J. Reich

1 - Spatial confounding is a phenomenon that has been studied extensively in recent years in the statistical literature to describe and mitigate apparent inconsistencies between the results obtained by regression models with and without…

The spatial linear mixed model (SLMM) consists of fixed and spatial random effects that may be linearly dependent. Partially motivated as a means to address potential issues with confounding, the Restricted spatial regression (RSR) model…

Methodology · Statistics 2026-03-24 Jonathan R. Bradley

Studies in environmental and epidemiological sciences are often spatially varying and observational in nature with the aim of establishing cause and effect relationships. One of the major challenges with such studies is the presence of…

Methodology · Statistics 2023-05-16 Sayli Pokal , Yawen Guan , Honglang Wang , Yuzhen Zhou
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