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Treatment effect estimation involves assessing the impact of different treatments on individual outcomes. Current methods estimate Conditional Average Treatment Effect (CATE) using observational datasets where covariates are collected…

Machine Learning · Computer Science 2025-02-10 Lokesh Nagalapatti , Pranava Singhal , Avishek Ghosh , Sunita Sarawagi

The average treatment effect on the treated (ATT) in a staggered-adoption panel is estimated using an intercept-augmented synthetic-control (SCM) estimator. A weighted parallel trends plus an intercept shift, together with mild regularity…

Methodology · Statistics 2025-08-08 Michael Guggisberg

This paper presents a generic analytical framework tailored for surrogate safety measures (SSMs) that is versatile across various highway geometries, capable of encompassing vehicle dynamics of differing dimensionality and fidelity, and…

Systems and Control · Electrical Eng. & Systems 2024-05-28 Sixu Li , Mohammad Anis , Dominique Lord , Hao Zhang , Yang Zhou , Xinyue Ye

Synthetic control (SC) models are widely used to estimate causal effects in settings with observational time-series data. To identify the causal effect on a target unit, SC requires the existence of correlated units that are not impacted by…

Methodology · Statistics 2024-06-18 Michael O'Riordan , Ciarán M. Gilligan-Lee

This paper introduces Smart Predict Then Control (SPC), a control aware refinement procedure for model based control. SPC refines a prediction oriented model by optimizing a surrogate objective that evaluates candidate models through the…

Systems and Control · Electrical Eng. & Systems 2026-03-26 Jiachen Li , Shihao Li , Dongmei Chen

Surrogate markers are often employed in clinical trials to replace primary outcomes that may be difficult, expensive, or time-consuming to measure directly. These markers can accelerate the evaluation of new treatments, provided they…

Methodology · Statistics 2026-03-17 Pietro Carlotti , Layla Parast

We consider the task of causal imputation, where we aim to predict the outcomes of some set of actions across a wide range of possible contexts. As a running example, we consider predicting how different drugs affect cells from different…

Machine Learning · Statistics 2024-09-19 Alvaro Ribot , Chandler Squires , Caroline Uhler

Causal inference from observational data is crucial for many disciplines such as medicine and economics. However, sharp bounds for causal effects under relaxations of the unconfoundedness assumption (causal sensitivity analysis) are subject…

Machine Learning · Computer Science 2023-10-17 Dennis Frauen , Valentyn Melnychuk , Stefan Feuerriegel

Deciding on an appropriate intervention requires a causal model of a treatment, the outcome, and potential mediators. Causal mediation analysis lets us distinguish between direct and indirect effects of the intervention, but has mostly been…

Machine Learning · Computer Science 2023-06-19 Çağlar Hızlı , ST John , Anne Juuti , Tuure Saarinen , Kirsi Pietiläinen , Pekka Marttinen

Prescriptive Process Monitoring (PresPM) recommends interventions during business processes to optimize key performance indicators (KPIs). In realistic settings, interventions are rarely isolated: organizations need to align sequences of…

Machine Learning · Computer Science 2026-01-12 Jakob De Moor , Hans Weytjens , Johannes De Smedt , Jochen De Weerdt

A common practice in clinical trials is to evaluate a treatment effect on an intermediate endpoint when the true outcome of interest would be difficult or costly to measure. We consider how to validate intermediate endpoints in a…

Methodology · Statistics 2022-11-30 Emily K. Roberts , Michael R. Elliott , Jeremy M. G. Taylor

This paper investigates the use of synthetic control methods for causal inference in macroeconomic settings when dealing with possibly nonstationary data. While the synthetic control approach has gained popularity for estimating…

Econometrics · Economics 2025-05-29 Zhentao Shi , Jin Xi , Haitian Xie

Consider a setting where there are $N$ heterogeneous units and $p$ interventions. Our goal is to learn unit-specific potential outcomes for any combination of these $p$ interventions, i.e., $N \times 2^p$ causal parameters. Choosing a…

Methodology · Statistics 2024-01-17 Abhineet Agarwal , Anish Agarwal , Suhas Vijaykumar

In causal inference, it is common to estimate the causal effect of a single treatment variable on an outcome. However, practitioners may also be interested in the effect of simultaneous interventions on multiple covariates of a fixed target…

Methodology · Statistics 2022-11-24 Jaime Roquero Gimenez , Dominik Rothenhäusler

We consider the asymptotic properties of the Synthetic Control (SC) estimator when both the number of pre-treatment periods and control units are large. If potential outcomes follow a linear factor model, we provide conditions under which…

Econometrics · Economics 2020-05-27 Bruno Ferman

Skepticism about the assumption of no unmeasured confounding, also known as exchangeability, is often warranted in making causal inferences from observational data; because exchangeability hinges on an investigator's ability to accurately…

Methodology · Statistics 2023-02-22 Yifan Cui , Hongming Pu , Xu Shi , Wang Miao , Eric Tchetgen Tchetgen

We present a hybrid sampling-surrogate approach for reducing the computational expense of uncertainty quantification in nonlinear dynamical systems. Our motivation is to enable rapid uncertainty quantification in complex mechanical systems…

Computation · Statistics 2022-01-27 Hang Yang , Yuji Fujii , K. W. Wang , Alex A. Gorodetsky

We present a new estimator for causal effects with panel data that builds on insights behind the widely used difference in differences and synthetic control methods. Relative to these methods we find, both theoretically and empirically,…

Methodology · Statistics 2025-09-22 Dmitry Arkhangelsky , Susan Athey , David A. Hirshberg , Guido W. Imbens , Stefan Wager

Causal machine learning has the potential to revolutionize decision-making by combining the predictive power of machine learning algorithms with the theory of causal inference. However, these methods remain underutilized by the broader…

The identification of surrogate markers is motivated by their potential to make decisions sooner about a treatment effect. However, few methods have been developed to actually use a surrogate marker to test for a treatment effect in a…

Methodology · Statistics 2024-09-17 Layla Parast , Jay Bartroff
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