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Parkinsons disease (PD) diagnosis is challenging due to subtle early clinical signs. F-DOPA PET is commonly used for early PD diagnosis. We explore the potential of machine-learning (ML) based EEG features extracted from single-channel EEG…

Neurons and Cognition · Quantitative Biology 2023-08-08 Lior Molcho , Neta B. Maimon , Neomi Hezi , Talya Zeimer , Nathan Intrator , Tanya Gurevich

Parkinson's disease (PD) is a common and complex neurodegenerative disorder with 5 stages in the Hoehn and Yahr scaling. Given the heterogeneity of PD, it is challenging to classify early stages 1 and 2 and detect brain function…

Neurons and Cognition · Quantitative Biology 2022-07-22 Xueqi Guo , Sule Tinaz , Nicha C. Dvornek

Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system characterized by motor and non-motor symptoms. As the disease progresses, patients alternate periods in which motor symptoms are mitigated due to…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-26 Anna Pompili , Rubén Solera-Ureña , Alberto Abad , Rita Cardoso , Isabel Guimarães , Margherita Fabbri , Isabel P. Martins , Joaquim Ferreira

Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor symptoms, including altered voice production in the early stages. Early diagnosis is crucial not only to improve PD patients' quality of life but also to…

Audio and Speech Processing · Electrical Eng. & Systems 2025-01-15 Maksim Siniukov , Ellie Xing , Sanaz Attaripour Isfahani , Mohammad Soleymani

This work is concerned with devising a robust Parkinson's (PD) disease detector from speech in real-world operating conditions using (i) foundational models, and (ii) speech enhancement (SE) methods. To this end, we first fine-tune several…

Audio and Speech Processing · Electrical Eng. & Systems 2025-11-13 Moreno La Quatra , Maria Francesca Turco , Torbjørn Svendsen , Giampiero Salvi , Juan Rafael Orozco-Arroyave , Sabato Marco Siniscalchi

Parkinson's disease (PD) is a debilitating neurological disorder that necessitates precise and early diagnosis for effective patient care. This study aims to develop a diagnostic model capable of achieving both high accuracy and minimizing…

Machine Learning · Computer Science 2024-01-30 Seyedeh Zahra Seyedi Hosseininian , Ahmadreza Tajari , Mohsen Ghalehnoie , Alireza Alfi

Convolutional neural networks (CNN) are widely used for speech emotion recognition (SER). In such cases, the short time fourier transform (STFT) spectrogram is the most popular choice for representing speech, which is fed as input to the…

Audio and Speech Processing · Electrical Eng. & Systems 2019-08-09 Shruti Gupta , Md. Shah Fahad , Akshay Deepak

Recent studies have demonstrated that analysis of laboratory-quality voice recordings can be used to accurately differentiate people diagnosed with Parkinson's disease (PD) from healthy controls (HC). These findings could help facilitate…

Applications · Statistics 2019-05-22 Siddharth Arora , Ladan Baghai-Ravary , Athanasios Tsanas

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuron loss and the accumulation of abnormal synuclein. PD presents both motor and non-motor symptoms that progressively impair…

Machine Learning · Computer Science 2025-04-07 Masahiro Matsumoto , Abu Saleh Musa Miah , Nobuyoshi Asai , Jungpil Shin

Parkinson's disease (PD) is a progressive neurodegenerative disorder that, in addition to directly impairing functional mobility, is frequently associated with vocal impairments such as hypophonia and dysarthria, which typically manifest in…

Accurate and early prediction of a disease allows to plan and improve a patient's quality of future life. During pandemic situations, the medical decision becomes a speed challenge in which physicians have to act fast to diagnose and…

Machine Learning · Computer Science 2022-06-09 Pierluigi Costanzo , Kalia Orphanou

Background and Objective: Parkinson's disease (PD) is the second most common progressive neurological condition after Alzheimer's, characterized by motor and non-motor symptoms. Developing a method to diagnose the condition in its beginning…

Machine Learning · Computer Science 2022-10-05 Paria Ghaheri , Hamid Nasiri , Ahmadreza Shateri , Arman Homafar

Speech impairments in Parkinson's disease (PD) provide significant early indicators for diagnosis. While models for speech-based PD detection have shown strong performance, their interpretability remains underexplored. This study…

Sound · Computer Science 2024-11-14 Eleonora Mancini , Francesco Paissan , Paolo Torroni , Mirco Ravanelli , Cem Subakan

Using speech samples as a biomarker is a promising avenue for detecting and monitoring the progression of Parkinson's disease (PD), but there is considerable disagreement in the literature about how best to collect and analyze such data.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-07-24 Peter Plantinga , Briac Cordelle , Dominique Louër , Mirco Ravanelli , Denise Klein

Parkinson's disease is a progressive neurodegenerative disorder affecting motor and non-motor functions, with speech impairments among its earliest symptoms. Speech impairments offer a valuable diagnostic opportunity, with machine learning…

Machine Learning · Computer Science 2025-04-25 Lorenzo Simone , Mauro Giuseppe Camporeale , Vito Marco Rubino , Vincenzo Gervasi , Giovanni Dimauro

Speech impairments are prevalent biomarkers for Parkinson's Disease (PD), motivating the development of diagnostic techniques using speech data for clinical applications. Although deep acoustic features have shown promise for PD…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-01 Emmy Postma , Cristian Tejedor-Garcia

Parkinson's disease patients develop different speech impairments that affect their communication capabilities. The automatic assessment of the speech of the patients allows the development of computer aided tools to support the diagnosis…

Machine Learning · Computer Science 2020-02-12 J. C. Vásquez-Correa , T. Arias-Vergara , C. D. Rios-Urrego , M. Schuster , J. Rusz , J. R. Orozco-Arroyave , E. Nöth

Clinical depression or Major Depressive Disorder (MDD) is a common and serious medical illness. In this paper, a deep recurrent neural network-based framework is presented to detect depression and to predict its severity level from speech.…

Human-Computer Interaction · Computer Science 2020-03-13 Emna Rejaibi , Ali Komaty , Fabrice Meriaudeau , Said Agrebi , Alice Othmani

Parkinson's disease (PD) severity diagnosis is crucial for early detecting potential patients and adopting tailored interventions. Diagnosing PD based on facial expression is grounded in PD patients' "masked face" symptom and gains growing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yintao Zhou , Wei Huang , Zhengyu Li , Jing Huang , Meng Pang

Severity assessment of Parkinson's disease (PD) using wearable sensors offers an effective, objective basis for clinical management. However, general-purpose time series models often lack pathological specificity in feature extraction,…

Machine Learning · Computer Science 2025-10-14 Weiming Zhao , Xulong Wang , Jun Qi , Yun Yang , Po Yang