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We consider the scenario where important signals are not strong enough to be separable from a large amount of noise. Such weak signals commonly exist in large-scale data analysis and play vital roles in many biomedical applications.…

Tensor-based morphometry (TBM) aims at showing local differences in brain volumes with respect to a common template. TBM images are smooth but they exhibit (especially in diseased groups) higher values in some brain regions called lateral…

The prediction and selection of lesion features are two important tasks in voxel-based neuroimage analysis. Existing multivariate learning models take two tasks equivalently and optimize simultaneously. However, in addition to lesion…

Rare and Weak models for multiple hypothesis testing assume that only a small proportion of the tested hypotheses concern non-null effects and the individual effects are only moderately large, so they generally do not stand out…

To date, several methods have been developed to explain deep learning algorithms for classification tasks. Recently, an adaptation of two of such methods has been proposed to generate instance-level explainable maps in a semantic…

White matter hyperintensities (WMH) are a hallmark of cerebrovascular disease and multiple sclerosis. Automated WMH segmentation methods enable quantitative analysis via estimation of total lesion load, spatial distribution of lesions, and…

We implement a visual interpretability method Layer-wise Relevance Propagation (LRP) on top of 3D U-Net trained to perform lesion segmentation on the small dataset of multi-modal images provided by ISLES 2017 competition. We demonstrate…

Functional Magnetic Resonance Imaging (fMRI) maps cerebral activation in response to stimuli but this activation is often difficult to detect, especially in low-signal contexts and single-subject studies. Accurate activation detection can…

Neural demyelination and brain damage accumulated in white matter appear as hyperintense areas on T2-weighted MRI scans in the form of lesions. Modeling binary images at the population level, where each voxel represents the existence of a…

In the 70s a novel branch of statistics emerged focusing its effort in selecting a function in the pattern recognition problem, which fulfils a definite relationship between the quality of the approximation and its complexity. These…

Accurate automated detection of recurrent prostate cancer in PSMA PET/CT scans is challenging due to heterogeneous lesion size, activity, anatomical location, and intra- and inter-class imbalances. Conventional deep learning loss functions…

Cause-of-death data is fundamental for understanding population health trends and inequalities as well as designing and evaluating public health interventions. A significant proportion of global deaths, particularly in low- and…

Localization of focal vascular lesions on brain MRI is an important component of research on the etiology of neurological disorders. However, manual annotation of lesions can be challenging, time-consuming and subject to observer bias.…

Deep learning (DL) networks have recently been shown to outperform other segmentation methods on various public, medical-image challenge datasets [3,11,16], especially for large pathologies. However, in the context of diseases such as…

This paper focuses on the uncertainty estimation for white matter lesions (WML) segmentation in magnetic resonance imaging (MRI). On one side, voxel-scale segmentation errors cause the erroneous delineation of the lesions; on the other…

White matter hyperintensities (WMH) and ischaemic stroke lesions (ISL) are imaging features associated with cerebral small vessel disease (SVD) that are visible on brain magnetic resonance imaging (MRI) scans. The development and validation…

Multivariate Pattern (MVP) classification holds enormous potential for decoding visual stimuli in the human brain by employing task-based fMRI data sets. There is a wide range of challenges in the MVP techniques, i.e. decreasing noise and…

Unique identification of multiple sclerosis (MS) white matter lesions (WMLs) is important to help characterize MS progression. WMLs are routinely identified from magnetic resonance images (MRIs) but the resultant total lesion load does not…

In this article, we propose a generalized weighted version of the well-known Benjamini-Hochberg (BH) procedure. The rigorous weighting scheme used by our method enables it to encode structural information from simultaneous multi-way…

We propose a method for comparing survival data based on the higher criticism of p-values obtained from multiple exact hypergeometric tests. The method accommodates non-informative right-censorship and is sensitive to hazard differences in…