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Dementia, a progressive neurodegenerative disorder, affects memory, reasoning, and daily functioning, creating challenges for individuals and healthcare systems. Early detection is crucial for timely interventions that may slow disease…

Neurons and Cognition · Quantitative Biology 2025-03-04 Sahar Sinene Mehdoui , Abdelhamid Bouzid , Daniel Sierra-Sosa , Adel Elmaghraby

In this work we explore how language models can be employed to analyze language and discriminate between mentally impaired and healthy subjects through the perplexity metric. Perplexity was originally conceived as an information-theoretic…

Computation and Language · Computer Science 2023-02-03 Davide Colla , Matteo Delsanto , Marco Agosto , Benedetto Vitiello , Daniele Paolo Radicioni

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease affecting 50 million people worldwide. Low-cost, accurate identification of key markers of AD is crucial for timely diagnosis and intervention. Language impairment is one…

Computation and Language · Computer Science 2025-05-27 Tingyu Mo , Jacqueline C. K. Lam , Victor O. K. Li , Lawrence Y. L. Cheung

Dementia is a neuropsychiatric brain disorder that usually occurs when one or more brain cells stop working partially or at all. Diagnosis of this disorder in the early phases of the disease is a vital task to rescue patients lives from bad…

Machine Learning · Computer Science 2022-09-13 Sinan Faouri , Mahmood AlBashayreh , Mohammad Azzeh

Recent progress has been made in detecting early stage dementia entirely through recordings of patient speech. Multimodal speech analysis methods were applied to the PROCESS challenge, which requires participants to use audio recordings of…

Audio and Speech Processing · Electrical Eng. & Systems 2025-02-14 Lei Chi , Arav Sharma , Ari Gebhardt , Joseph T. Colonel

Dementia is a neurodegenerative disease that causes gradual cognitive impairment, which is very common in the world and undergoes a lot of research every year to prevent and cure it. It severely impacts the patient's ability to remember…

In recent years there has been a burgeoning interest in the use of computational methods to distinguish between elicited speech samples produced by patients with dementia, and those from healthy controls. The difference between perplexity…

Computation and Language · Computer Science 2020-06-30 Trevor Cohen , Serguei Pakhomov

Background: Subtle changes in spontaneous language production are among the earliest indicators of cognitive decline. Identifying linguistically interpretable markers of dementia can support transparent and clinically grounded screening…

Computation and Language · Computer Science 2026-02-12 Artsvik Avetisyan , Sachin Kumar

Introduction: We present a screening method for early dementia using features based on sound objects as voice biomarkers. Methods: The final dataset used for machine learning models consisted of 266 observations, with a distribution of 186…

The use of spontaneous language to derive appropriate digital markers has become an emergent, promising and non-intrusive method to diagnose and monitor dementia. Here we propose methods to capture language coherence as a cost-effective,…

Computation and Language · Computer Science 2023-10-17 Dimitris Gkoumas , Adam Tsakalidis , Maria Liakata

We present an approach to automatic detection of Alzheimer's type dementia based on characteristics of spontaneous spoken language dialogue consisting of interviews recorded in natural settings. The proposed method employs additive logistic…

Audio and Speech Processing · Electrical Eng. & Systems 2018-11-27 Saturnino Luz , Sofia de la Fuente , Pierre Albert

Automatic detection of Alzheimer's dementia by speech processing is enhanced when features of both the acoustic waveform and the content are extracted. Audio and text transcription have been widely used in health-related tasks, as spectral…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-12 Edward L. Campbell , Laura Docío-Fernández , Javier Jiménez Raboso , Carmen García-Mateo

Alzheimer's disease (AD) constitutes a complex neurocognitive disease and is the main cause of dementia. Although many studies have been proposed targeting at diagnosing dementia through spontaneous speech, there are still limitations.…

Computation and Language · Computer Science 2023-08-24 Loukas Ilias , Dimitris Askounis

The global prevalence of dementia is projected to double by 2050, highlighting the urgent need for scalable diagnostic tools. This study utilizes digital cognitive tasks with eye-tracking data correlated with memory processes to distinguish…

Human-Computer Interaction · Computer Science 2025-08-28 Tomás Silva Santos Rocha , Anastasiia Mikhailova , Moreno I. Coco , José Santos-Victor

Dementia is a neurological syndrome marked by cognitive decline. Alzheimer's disease (AD) and Frontotemporal dementia (FTD) are the common forms of dementia, each with distinct progression patterns. EEG, a non-invasive tool for recording…

Signal Processing · Electrical Eng. & Systems 2024-08-21 Shivani Ranjan , Ayush Tripathi , Harshal Shende , Robin Badal , Amit Kumar , Pramod Yadav , Deepak Joshi , Lalan Kumar

Deep transformer models have been used to detect linguistic anomalies in patient transcripts for early Alzheimer's disease (AD) screening. While pre-trained neural language models (LMs) fine-tuned on AD transcripts perform well, little…

Computation and Language · Computer Science 2025-06-09 Zhecheng Sheng , Xiruo Ding , Brian Hur , Changye Li , Trevor Cohen , Serguei Pakhomov

The close link between cognitive decline and language has fostered long-standing collaboration between the NLP and medical communities in dementia research. To examine this, we reviewed over 240 papers applying NLP to dementia-related…

Computation and Language · Computer Science 2025-02-11 Lotem Peled-Cohen , Roi Reichart

Based on official estimates, 50 million people worldwide are affected by dementia, and this number increases by 10 million new patients every year. Without a cure, clinical prognostication and early intervention represent the most effective…

Computation and Language · Computer Science 2024-09-06 Francisco de Arriba-Pérez , Silvia García-Méndez

One of the most prevalent symptoms among the elderly population, dementia, can be detected by classifiers trained on linguistic features extracted from narrative transcripts. However, these linguistic features are impacted in a similar but…

Machine Learning · Computer Science 2019-09-10 Zining Zhu , Jekaterina Novikova , Frank Rudzicz

In this paper, we exploit a Fully Convolutional Network (FCN) to analyze the audio data of spontaneous speech for dementia detection. A fully convolutional network accommodates speech samples with varying lengths, thus enabling us to…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-18 Youxiang Zhu , Xiaohui Liang