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Medication adherence is critical for the recovery of adolescents and young adults (AYAs) who have undergone hematopoietic cell transplantation (HCT). However, maintaining adherence is challenging for AYAs after hospital discharge, who…

Machine Learning · Computer Science 2025-05-22 Ziping Xu , Hinal Jajal , Sung Won Choi , Inbal Nahum-Shani , Guy Shani , Alexandra M. Psihogios , Pei-Yao Hung , Susan Murphy

Dental disease is one of the most common chronic diseases despite being largely preventable. However, professional advice on optimal oral hygiene practices is often forgotten or abandoned by patients. Therefore patients may benefit from…

Artificial Intelligence · Computer Science 2022-09-15 Anna L. Trella , Kelly W. Zhang , Inbal Nahum-Shani , Vivek Shetty , Finale Doshi-Velez , Susan A. Murphy

In recent years, reinforcement learning (RL) has acquired a prominent position in health-related sequential decision-making problems, gaining traction as a valuable tool for delivering adaptive interventions (AIs). However, in part due to a…

Machine Learning · Statistics 2024-07-16 Nina Deliu , Joseph Jay Williams , Bibhas Chakraborty

Mediation analysis learns the causal effect transmitted via mediator variables between treatments and outcomes and receives increasing attention in various scientific domains to elucidate causal relations. Most existing works focus on…

Machine Learning · Statistics 2023-09-06 Lin Ge , Jitao Wang , Chengchun Shi , Zhenke Wu , Rui Song

While reinforcement learning (RL) has proven to be the approach of choice for tackling many complex problems, it remains challenging to develop and deploy RL agents in real-life scenarios successfully. This paper presents pH-RL…

Artificial Intelligence · Computer Science 2021-04-01 Ali el Hassouni , Mark Hoogendoorn , Marketa Ciharova , Annet Kleiboer , Khadicha Amarti , Vesa Muhonen , Heleen Riper , A. E. Eiben

Dental disease is a prevalent chronic condition associated with substantial financial burden, personal suffering, and increased risk of systemic diseases. Despite widespread recommendations for twice-daily tooth brushing, adherence to…

Artificial Intelligence · Computer Science 2024-12-20 Anna L. Trella , Kelly W. Zhang , Hinal Jajal , Inbal Nahum-Shani , Vivek Shetty , Finale Doshi-Velez , Susan A. Murphy

There is a growing interest in using reinforcement learning (RL) to personalize sequences of treatments in digital health to support users in adopting healthier behaviors. Such sequential decision-making problems involve decisions about…

Machine Learning · Computer Science 2023-08-08 Susobhan Ghosh , Raphael Kim , Prasidh Chhabria , Raaz Dwivedi , Predrag Klasnja , Peng Liao , Kelly Zhang , Susan Murphy

Regular physical activity is known to be beneficial to people suffering from diabetes type 2. Nevertheless, most such people are sedentary. Smartphones create new possibilities for helping people to adhere to their physical activity goals,…

Computers and Society · Computer Science 2018-05-16 Irit Hochberg , Guy Feraru , Mark Kozdoba , Shie Mannor , Moshe Tennenholtz , Elad Yom-Tov

Personalized decision systems in healthcare and behavioral support often rely on static rule-based or engagement-maximizing heuristics that overlook users' emotional context and ethical constraints. Such approaches risk recommending…

Machine Learning · Computer Science 2025-11-14 Garapati Keerthana , Manik Gupta

Online reinforcement learning (RL) algorithms are increasingly used to personalize digital interventions in the fields of mobile health and online education. Common challenges in designing and testing an RL algorithm in these settings…

Machine Learning · Computer Science 2022-09-01 Anna L. Trella , Kelly W. Zhang , Inbal Nahum-Shani , Vivek Shetty , Finale Doshi-Velez , Susan A. Murphy

With the recent evolution of mobile health technologies, health scientists are increasingly interested in developing just-in-time adaptive interventions (JITAIs), typically delivered via notification on mobile device and designed to help…

Machine Learning · Computer Science 2019-09-10 Peng Liao , Kristjan Greenewald , Predrag Klasnja , Susan Murphy

Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…

Computers and Society · Computer Science 2020-11-05 Hua Zheng , Ilya O. Ryzhov , Wei Xie , Judy Zhong

Reinforcement Learning (RL) faces significant challenges in adaptive healthcare interventions, such as dementia care, where data is scarce, decisions require interpretability, and underlying patient-state dynamic are complex and causal in…

Robotics · Computer Science 2025-12-02 Wenzheng Zhao , Ran Zhang , Ruth Palan Lopez , Shu-Fen Wung , Fengpei Yuan

Motivated by the emerging needs of personalized preventative intervention in many healthcare applications, we consider a multi-stage, dynamic decision-making problem in the online setting with unknown model parameters. To deal with the…

Machine Learning · Computer Science 2022-11-17 Xinyun Chen , Pengyi Shi , Shanwen Pu

Mobile health leverages personalized and contextually tailored interventions optimized through bandit and reinforcement learning algorithms. In practice, however, challenges such as participant heterogeneity, nonstationarity, and nonlinear…

Personalization is very powerful in improving the effectiveness of health interventions. Reinforcement learning (RL) algorithms are suitable for learning these tailored interventions from sequential data collected about individuals.…

Artificial Intelligence · Computer Science 2020-05-22 Ali el Hassouni , Mark Hoogendoorn , Martijn van Otterlo , A. E. Eiben , Vesa Muhonen , Eduardo Barbaro

In the wake of the vast population of smart device users worldwide, mobile health (mHealth) technologies are hopeful to generate positive and wide influence on people's health. They are able to provide flexible, affordable and portable…

Machine Learning · Computer Science 2017-08-25 Feiyun Zhu , Peng Liao , Xinliang Zhu , Yaowen Yao , Junzhou Huang

Due to the popularity of smartphones and wearable devices nowadays, mobile health (mHealth) technologies are promising to bring positive and wide impacts on people's health. State-of-the-art decision-making methods for mHealth rely on some…

Machine Learning · Computer Science 2017-08-15 Feiyun Zhu , Jun Guo , Zheng Xu , Peng Liao , Junzhou Huang

Effective patient monitoring is vital for timely interventions and improved healthcare outcomes. Traditional monitoring systems often struggle to handle complex, dynamic environments with fluctuating vital signs, leading to delays in…

Machine Learning · Computer Science 2024-10-30 Thanveer Shaik , Xiaohui Tao , Lin Li , Haoran Xie , Hong-Ning Dai , Feng Zhao , Jianming Yong

Online reinforcement learning (RL) is increasingly popular for the personalized mobile health (mHealth) intervention. It is able to personalize the type and dose of interventions according to user's ongoing statuses and changing needs.…

Machine Learning · Computer Science 2017-05-23 Feiyun Zhu , Peng Liao
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