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Turning rich neuroimaging data into mechanistic insight remains challenging. Statistical models capture associations but remain largely agnostic to underlying mechanisms. Biophysical models embody candidate mechanisms but remain difficult…

Neurons and Cognition · Quantitative Biology 2026-01-15 Dominic Boutet , Sylvain Baillet

We consider the hypothesis testing problem of detecting a shift between the means of two multivariate normal distributions in the high-dimensional setting, allowing for the data dimension p to exceed the sample size n. Specifically, we…

Statistics Theory · Mathematics 2015-09-15 Miles E. Lopes , Laurent J. Jacob , Martin J. Wainwright

In this paper, we examine the strength of deep learning technique for diagnosing lung cancer on medical image analysis problem. Convolutional neural networks (CNNs) models become popular among the pattern recognition and computer vision…

Computer Vision and Pattern Recognition · Computer Science 2018-04-24 Mehdi Fatan Serj , Bahram Lavi , Gabriela Hoff , Domenec Puig Valls

Alterations in nuclear morphology are useful adjuncts and even diagnostic tools used by pathologists in the diagnosis and grading of many tumors, particularly malignant tumors. Large datasets such as TCGA and the Human Protein Atlas, in…

Quantitative Methods · Quantitative Biology 2023-02-06 Mohammad Shifat E Rabbi , Natasha Ironside , John A Ozolek , Rajendra Singh , Liron Pantanowitz , Gustavo K Rohde

With the emergence of dynamic multiplex networks, corresponding to graphs where multiple types of edges evolve over time, a key inferential task is to determine whether the layers associated with different edge types differ in their…

Methodology · Statistics 2025-12-04 Maximilian Baum , Francesco Sanna Passino , Axel Gandy

Recently, lung nodule detection methods based on deep learning have shown excellent performance in the medical image processing field. Considering that only a few public lung datasets are available and lung nodules are more difficult to…

Image and Video Processing · Electrical Eng. & Systems 2024-03-08 Yujiang Chen , Mei Xie

The Euler calculus -- an integral calculus based on Euler characteristic as a valuation on constructible functions -- is shown to be an incisive tool for answering questions about injectivity and invertibility of recent transforms based on…

Algebraic Topology · Mathematics 2018-06-15 Robert Ghrist , Rachel Levanger , Huy Mai

We propose a deep learning based method for classification of commonly occurring pathologies in chest X-ray images. The vast number of publicly available chest X-ray images provides the data necessary for successfully employing deep…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 Mohammad S. Majdi , Khalil N. Salman , Michael F. Morris , Nirav C. Merchant , Jeffrey J. Rodriguez

Early detection of lung cancer is crucial for effective treatment and relies on accurate volumetric assessment of pulmonary nodules in CT scans. Traditional methods, such as consolidation-to-tumor ratio (CTR) and spherical approximation,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-29 Yihan Zhou , Haocheng Huang , Yue Yu , Jianhui Shang

The Euler Characteristic Transform (ECT) has proven to be a powerful representation, combining geometrical and topological characteristics of shapes and graphs. However, the ECT was hitherto unable to learn task-specific representations. We…

Machine Learning · Computer Science 2024-03-20 Ernst Roell , Bastian Rieck

We develop a computational framework to quantify uncertainty in shear elastography imaging of anomalies in tissues. We adopt a Bayesian inference formulation. Given the observed data, a forward model and their uncertainties, we find the…

Numerical Analysis · Mathematics 2023-06-07 Ana Carpio , Elena Cebrian , Andrea Gutierrez

A virtual try-on method takes a product image and an image of a model and produces an image of the model wearing the product. Most methods essentially compute warps from the product image to the model image and combine using image…

Computer Vision and Pattern Recognition · Computer Science 2020-03-30 Kedan Li , Min Jin Chong , Jingen Liu , David Forsyth

We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Onur Ozdemir , Rebecca L. Russell , Andrew A. Berlin

We present a novel method for testing the hypothesis of equality of two correlation matrices using paired high-dimensional datasets. We consider test statistics based on the average of squares, maximum and sum of exceedances of Fisher…

Methodology · Statistics 2018-04-10 Adria Caballe , Natalia Bochkina , Claus Mayer , Ioannis Papastathopoulos

Noise is one of the major problems that hinder an effective texture analysis of disease in medical images, which may cause variability in the reported diagnosis. In this paper seven texture measurement methods (two wavelet, two model and…

Computer Vision and Pattern Recognition · Computer Science 2015-12-29 Omar Sultan Al-Kadi

During clinical practice, radiologists often use attributes, e.g. morphological and appearance characteristics of a lesion, to aid disease diagnosis. Effectively modeling attributes as well as all relationships involving attributes could…

Computer Vision and Pattern Recognition · Computer Science 2022-08-22 Gangming Zhao , Quanlong Feng , Chaoqi Chen , Zhen Zhou , Yizhou Yu

In recent years, it has become common practice in neuroscience to use networks to summarize relational information in a set of measurements, typically assumed to be reflective of either functional or structural relationships between regions…

Applications · Statistics 2017-03-20 Cedric E. Ginestet , Jun Li , Prakash Balachandran , Steven Rosenberg , Eric D. Kolaczyk

A critical step in data analysis for many different types of experiments is the identification of features with theoretically defined shapes in N-dimensional datasets; examples of this process include finding peaks in multi-dimensional…

Data Analysis, Statistics and Probability · Physics 2022-08-25 Korak Kumar Ray , Anjali R. Verma , Ruben L. Gonzalez , Colin D. Kinz-Thompson

Medical image analysis using deep neural networks has been actively studied. Deep neural networks are trained by learning data. For accurate training of deep neural networks, the learning data should be sufficient, of good quality, and…

Image and Video Processing · Electrical Eng. & Systems 2021-01-05 Sunho Kim , Byungjai Kim , HyunWook Park

The purpose of this study is to provide means to physicians for automated and fast recognition of airways diseases. In this work, we mainly focus on measures that can be easily recorded using a spirometer. The signals used in this framework…

Machine Learning · Computer Science 2021-11-09 Riccardo Dio , André Galligo , Angelos Mantzaflaris , Benjamin Mauroy